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class=\"wp-block-heading\">3\u500b\u5148\u5929\u56e0\u7d20\u5f71\u97ff\u8102\u80aa\u5b9a\u4f4d<\/h2>\n\n\n\n<p>\u81f3\u65bc\u8102\u80aa\u5b9a\u4f4d\u7684\u8a2d\u5b9a\uff0c\u7a76\u7adf\u662f\u5148\u5929\u9084\u662f\u5f8c\u5929\uff1f\u300c\u80a5\u80d6\u5728\u57fa\u56e0\u4e0a\u6709\u7740\u907a\u50b3\uff0c\u4f46\u7531\u65bc\u57fa\u56e0\u907a\u50b3\u7684\u96a8\u6a5f\u6027\u5927\uff0c\u82e5\u7236\u6bcd\u4e00\u80a5\u4e00\u7626\uff0c\u5b50\u5973\u6709\u4e00\u534a\u6a5f\u7387\u53ef\u80fd\u662f\u300e\u80a5\u5e95\u300f\u3002\u300d\u8881\u7f8e\u6b23\u8aaa\uff0c\u73fe\u6642\u6c92\u7814\u7a76\u7d71\u8a08\u907a\u50b3\u56e0\u7d20\u6709\u591a\u5927\u7a0b\u5ea6\u5c0e\u81f4\u80a5\u80d6\uff0c\u7136\u800c\u5148\u5929\u5f71\u97ff\u8102\u80aa\u5b9a\u4f4d\u6709\u4ee5\u4e0b\u56e0\u7d20\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb-1024x538.webp 1024w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb-300x158.webp 300w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb-150x79.webp 150w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb-768x404.webp 768w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb.webp 1143w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb-1024x538.jpg\" height=\"538\" width=\"1024\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb-1024x538.jpg 1024w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb-300x158.jpg 300w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb-150x79.jpg 150w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb-768x404.jpg 768w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/baeee38ae1174351ba7ae6ff1bd558cb.jpg 1143w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" class=\"wp-image-48475 sp-no-webp\" alt=\"\" fetchpriority=\"high\" decoding=\"async\"  > <\/picture><figcaption class=\"wp-element-caption\">\u8102\u80aa\u5b9a\u4f4d&#8211;\u5148\u5929\u56e0\u7d20\u52a0\u4e0a\u5f8c\u5929\u74b0\u5883\u5982\u98f2\u98df\u3001\u904b\u52d5\u3001\u7761\u7720\u7fd2\u6163\u7b49\uff0c\u6703\u4fc3\u6210\u8102\u80aa\u5b9a\u4f4d\u7684\u8a2d\u7f6e\uff0c\u5f62\u6210\u80a5\u7626\u9ad4\u8cea\u3002\uff08\u8a2d\u8a08\u5716\u7247\uff0cviolet-blue\u3001Olga Mazyarkina@iStockphoto\/\u660e\u5831\u88fd\u5716\uff09<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">1. \u907a\u50b3\u57fa\u56e0<\/h2>\n\n\n\n<p>\u9664\u4e86\u7236\u6bcd\u57fa\u56e0\u7684\u907a\u50b3\u6307\u4ee4\u5916\uff0c\u76ee\u524d\u5df2\u767c\u73fe\u903e200\u7a2e\u57fa\u56e0\u8207\u80a5\u80d6\u76f8\u95dc\uff0c\u4ee5\u6700\u5e38\u8ac7\u53ca\u7684\u9ed1\u7d20\u76ae\u8cea\u7d20\u53d7\u9ad44\uff08melanocortin-4 receptor\uff0c\u7c21\u7a31MC4R\uff09\u70ba\u4f8b\uff0cMC4R\u904b\u4f5c\u65bc\u4e0b\u4e18\u8166\uff0cMC4R\u8b8a\u7570\u6703\u4ee4\u5927\u8166\u7121\u6cd5\u611f\u77e5\u6291\u5236\u98df\u617e\u7684\u4fe1\u865f\uff0c\u56e0\u6b64\u5931\u53bb\u98fd\u8db3\u611f\u800c\u8b8a\u5f97\u55dc\u98df\u81f4\u80a5\u30022018\u5e74\u767c\u8868\u65bcNature Genetics\u7684\u7814\u7a76\u66f4\u6307\u51fa\uff0cMC4R\u548cKSR2\uff08kinase suppressor of ras 2\uff09\u7a81\u8b8a\u6703\u5c0e\u81f4\u6975\u5ea6\u80a5\u80d6\u3002\u7528\u65bcMC4R\u8b8a\u7570\u800c\u5c0e\u81f4\u80a5\u80d6\u75c7\u7684\u85e5\u7269\u5df2\u7372\u6b50\u7f8e\u5be9\u6279\u3002<br><br>MC4R\u8b8a\u7570\u800c\u5c0e\u81f4\u7684\u80a5\u80d6\u75c7\u5e38\u898b\u65bc\u5b69\u7ae5\u6642\u671f\uff0c\u82e5\u6210\u5e74\u6642\u624d\u767c\u80d6\uff0c\u5f80\u5f80\u4e0d\u662f\u55ae\u4e00\u57fa\u56e0\u8b8a\u7570\uff0c\u53ef\u80fd\u662f\u591a\u57fa\u56e0\u8b8a\u7570\u548c\u5f8c\u5929\u4e0d\u826f\u751f\u6d3b\u7fd2\u6163\u800c\u5c0e\u81f4\uff0c\u9019\u5c31\u8981\u900f\u904e\u6539\u5584\u751f\u6d3b\u7fd2\u6163\u6e1b\u80a5\uff0c\u60c5\u51b5\u56b4\u91cd\u8005\u6216\u9700\u8981\u8655\u65b9\u6e1b\u80a5\u85e5\uff0c\u751a\u81f3\u63a5\u53d7\u7e2e\u80c3\u624b\u8853\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6bcd\u4e73\u9935\u54fa\u5b30\u5152\u4e0d\u6613\u80a5<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>2. \u8868\u89c0\u907a\u50b3\u5b78\uff08epigenetics\uff09<\/strong><\/h2>\n\n\n\n<p>\u8868\u89c0\u907a\u50b3\u80fd\u900f\u904e\u6bcd\u9ad4\u884c\u70ba\u548c\u74b0\u5883\u5f71\u97ff\u57fa\u56e0\u8868\u73fe\uff0c\u8209\u4f8b\u8aaa\uff0c\u7814\u7a76\u5df2\u78ba\u8a8d\u6bcd\u9ad4\u5728\u61f7\u5b55\u671f\u9593\u651d\u53d6\u5927\u91cf\u8102\u80aa\u6703\u4ee4\u80ce\u5152\u300c\u80a5\u80d6\u300d\u3002\u8868\u89c0\u907a\u50b3\u8b93\u5b55\u5a66\u900f\u904e\u98f2\u98df\u8207\u751f\u6d3b\u7fd2\u6163\uff0c\u5f71\u97ff\u80ce\u5152\u5065\u5eb7\u3002\u82e5\u60f3\u70ba\u80ce\u5152\u6253\u4e0b\u5148\u5929\u826f\u597d\u57fa\u790e\uff0c\u5b55\u5a66\u61c9\u7dad\u6301\u5065\u5eb7\u98f2\u98df\u8207\u591a\u505a\u904b\u52d5\uff1b\u53e6\u5916\uff0c\u61c9\u907f\u514d\u904e\u5ea6\u9032\u88dc\u800c\u5c0e\u81f4\u9ad4\u91cd\u6025\u5287\u4e0a\u5347\uff0c\u4ea6\u61c9\u591a\u7559\u610f\u8840\u7cd6\u6307\u6578\uff0c\u907f\u514d\u60a3\u4e0a\u598a\u5a20\u7cd6\u5c3f\u75c5\uff0c\u4ee5\u6e1b\u5c11\u80ce\u5152\u65e5\u5f8c\u60a3\u4e0a\u80a5\u80d6\u75c7\u98a8\u96aa\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/5c324ae3224b47518f6eea56e30d5d7b.webp 489w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/5c324ae3224b47518f6eea56e30d5d7b-206x300.webp 206w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/5c324ae3224b47518f6eea56e30d5d7b-103x150.webp 103w\" sizes=\"(max-width: 489px) 100vw, 489px\" type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/5c324ae3224b47518f6eea56e30d5d7b.jpg\" height=\"711\" width=\"489\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/5c324ae3224b47518f6eea56e30d5d7b.jpg 489w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/5c324ae3224b47518f6eea56e30d5d7b-206x300.jpg 206w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/5c324ae3224b47518f6eea56e30d5d7b-103x150.jpg 103w\" sizes=\"(max-width: 489px) 100vw, 489px\" class=\"wp-image-48477 sp-no-webp\" alt=\"\" decoding=\"async\"  > <\/picture><figcaption class=\"wp-element-caption\">\u91ab\u751f\u5efa\u8b70\u4ee5\u6bcd\u4e73\u9935\u54fa\u5b30\u5152\uff0c\u5b69\u5b50\u4e0d\u5bb9\u6613\u8b8a\u80a5\u3002\uff08monzenmachi@iStockphoto\uff09<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>3. \u57fa\u56e0\u7d44\u5370\u8a18\uff08genomic imprinting\uff09<\/strong><\/h2>\n\n\n\n<p>\u57fa\u56e0\u7d44\u5370\u8a18\u662f\u4e00\u7a2e\u8868\u89c0\u907a\u50b3\u73fe\u8c61\uff0c\u610f\u6307\u4f86\u81ea\u7236\u7cfb\u6216\u6bcd\u7cfb\u7684\u7279\u5b9a\u57fa\u56e0\uff0c\u5177\u6709\u4e0d\u540c\u6d3b\u6027\uff0c\u800c\u5176\u4e2d\u4e00\u65b9\u57fa\u56e0\u51fa\u73fe\u8b8a\u5316\u88ab\u300c\u6a19\u8a18\u300d\u5f8c\uff0c\u907a\u50b3\u7d66\u5f8c\u4ee3\u3002\u5c0f\u80d6\u5a01\u5229\u7d9c\u5408\u5fb5\uff08Prader-Willi syndrome\uff09\u4fbf\u662f\u5176\u4e2d\u4e00\u4f8b\uff0c\u767c\u75c5\u5176\u4e2d\u4e00\u500b\u539f\u56e0\u662f\u4f86\u81ea\u7236\u89aa\u7b2c15\u689d\u67d3\u8272\u9ad4\u9577\u81c2\u529f\u80fd\u55aa\u5931\uff0c\u800c\u5c0e\u81f4\u7684\u907a\u50b3\u75be\u75c5\uff0c\u6703\u4ee4\u60a3\u8005\u55aa\u5931\u98fd\u809a\u611f\u89ba\u800c\u4e0d\u53d7\u63a7\u5730\u9032\u98df\uff0c\u7d42\u5f15\u767c\u56b4\u91cd\u80a5\u80d6\u75c7\u3002<br><br>\u53e6\u5916\uff0c\u5b30\u5e7c\u5152\u6642\u671f\u7a2e\u7a2e\u56e0\u7d20\u5982\u6bcd\u4e73\u9935\u54fa\u3001\u662f\u5426\u7d93\u5e38\u904e\u5206\u98fd\u809a\u3001\u6709\u6c92\u6709\u8db3\u5920\u904b\u52d5\u7b49\uff0c\u4ea6\u6703\u5f71\u97ff\u65e5\u5f8c\u8102\u80aa\u5b9a\u4f4d\u3002\u8881\u7f8e\u6b23\u5efa\u8b70\u4ee5\u6bcd\u4e73\u9935\u54fa\u5b30\u5152\uff0c\u5b69\u5b50\u4e0d\u5bb9\u6613\u8b8a\u80a5\u3002<br><br>\u5148\u5929\u56e0\u7d20\u52a0\u4e0a\u5f8c\u5929\u74b0\u5883\u5982\u98f2\u98df\u3001\u904b\u52d5\u3001\u7761\u7720\u7fd2\u6163\u7b49\uff0c\u4fbf\u6703\u4fc3\u6210\u8102\u80aa\u5b9a\u4f4d\u7684\u8a2d\u7f6e\uff0c\u5f62\u6210\u6240\u8b02\u80a5\u7626\u9ad4\u8cea\u3002\u7576\u8eab\u9ad4\u8a2d\u7f6e\u4e86\u8102\u80aa\u5b9a\u4f4d\uff0c\u82e5\u9ad4\u91cd\u8d85\u904e\u6216\u4f4e\u65bc\u9810\u8a2d\u7bc4\u570d\uff0c\u8eab\u9ad4\u4fbf\u6703\u555f\u52d5\u5404\u7a2e\u6a5f\u5236\u628a\u9ad4\u91cd\u62c9\u56de\u6b63\u8ecc\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d1a0099995c5409993030d0c0a982e8c-768x1024.webp 768w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d1a0099995c5409993030d0c0a982e8c-225x300.webp 225w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d1a0099995c5409993030d0c0a982e8c-112x150.webp 112w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d1a0099995c5409993030d0c0a982e8c.webp 800w\" sizes=\"(max-width: 768px) 100vw, 768px\" type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d1a0099995c5409993030d0c0a982e8c-768x1024.jpg\" height=\"1024\" width=\"768\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d1a0099995c5409993030d0c0a982e8c-768x1024.jpg 768w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d1a0099995c5409993030d0c0a982e8c-225x300.jpg 225w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d1a0099995c5409993030d0c0a982e8c-112x150.jpg 112w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d1a0099995c5409993030d0c0a982e8c.jpg 800w\" sizes=\"(max-width: 768px) 100vw, 768px\" class=\"wp-image-48478 sp-no-webp\" alt=\"\" decoding=\"async\"  > <\/picture><figcaption class=\"wp-element-caption\">\u8881\u7f8e\u6b23\uff08\u5f6d\u5826\u741b\u651d\uff09<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u6e1b\u80a5\u653b\u7565\uff1a\u9ad8\u6cb9\u9ad8\u7cd6\u990a\u300c\u80a5\u83cc\u300d \u9ad8\u7e96\u539f\u5f62\u98df\u7269\u990a\u300c\u7626\u83cc\u300d<\/strong><\/h2>\n\n\n\n<p>\u6539\u8b8a\u8102\u80aa\u5b9a\u4f4d\u4e26\u975e\u4e00\u671d\u4e00\u5915\uff0c\u77ed\u6642\u9593\u5167\u5927\u5e45\u6e1b\u91cd\u5bb9\u6613\u53cd\u5f48\u3002\u8981\u9577\u9060\u6539\u8b8a\u5b9a\u4f4d\uff0c\u5fc5\u9808\u4fdd\u6301\u5065\u5eb7\u751f\u6d3b\u7fd2\u6163\uff0c\u5305\u62ec\u5747\u8861\u98f2\u98df\u3001\u5145\u8db3\u7761\u7720\u3001\u6046\u5e38\u904b\u52d5\uff1b\u53e6\u5916\uff0c\u900f\u904e\u5065\u5eb7\u98f2\u98df\u57f9\u990a\u8178\u9053\u300c\u597d\u83cc\u300d\uff0c\u4ea6\u6709\u52a9\u6539\u8b8a\u8102\u80aa\u5b9a\u4f4d\u3002<br><br>\u5167\u5206\u6ccc\u53ca\u7cd6\u5c3f\u79d1\u5c08\u79d1\u91ab\u751f\u8881\u7f8e\u6b23\u6307\u51fa\uff0c\u5b30\u5152\u51fa\u751f\u6642\u8178\u9053\u662f\u7121\u83cc\uff0c\u958b\u59cb\u9032\u98df\u53ca\u63a5\u89f8\u5916\u5728\u74b0\u5883\u5f8c\uff0c\u5fae\u751f\u7269\u7fa4\u6162\u6162\u9032\u5165\u8178\u9053\u3002\u9019\u4e9b\u8178\u9053\u5fae\u751f\u7269\u7fa4\u7684\u7d44\u6210\u6703\u53d7\u98f2\u98df\u3001\u904b\u52d5\u3001\u7761\u7720\u7b49\u7fd2\u6163\u5f71\u97ff\u3002<br><br>\u5df2\u77e5\u6709\u4e0d\u540c\u8178\u9053\u83cc\u7fa4\u6703\u5f71\u97ff\u80a5\u7626\u3002\u7b2c\u4e00\u985e\u662f\u300c\u80a5\u83cc\u300d\u539a\u58c1\u83cc\u9580\uff08bacillota\uff09\uff0c\u6d88\u5316\u80fd\u529b\u5f37\uff0c\u80fd\u628a\u4e0d\u6613\u6d88\u5316\u7684\u98df\u7269\u5206\u89e3\u3002\u7b2c\u4e8c\u985e\u662f\u300c\u7626\u83cc\u300d \u64ec\u687f\u83cc\u9580\uff08bacteroidetes\uff09\uff0c\u5438\u6536\u71df\u990a\u6548\u7387\u8f03\u4f4e\u3002\u7576\u5169\u4eba\u5403\u540c\u4e00\u98df\u7269\uff0c\u80a5\u83cc\u8f03\u591a\u7684\u4eba\uff0c\u56e0\u6d88\u5316\u529b\u8f03\u5f37\u800c\u651d\u53d6\u5230\u8f03\u591a\u71b1\u91cf\uff1b\u7626\u83cc\u8f03\u591a\u7684\u4eba\u56e0\u6d88\u5316\u529b\u7a0d\u905c\uff0c\u651d\u53d6\u71b1\u91cf\u6703\u8f03\u5c11\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/a770785b9f8e48d5b3ab6086f0a7870a.webp 800w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/a770785b9f8e48d5b3ab6086f0a7870a-300x225.webp 300w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/a770785b9f8e48d5b3ab6086f0a7870a-150x113.webp 150w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/a770785b9f8e48d5b3ab6086f0a7870a-768x576.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/a770785b9f8e48d5b3ab6086f0a7870a.jpg\" height=\"600\" width=\"800\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/a770785b9f8e48d5b3ab6086f0a7870a.jpg 800w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/a770785b9f8e48d5b3ab6086f0a7870a-300x225.jpg 300w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/a770785b9f8e48d5b3ab6086f0a7870a-150x113.jpg 150w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/a770785b9f8e48d5b3ab6086f0a7870a-768x576.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" class=\"wp-image-48476 sp-no-webp\" alt=\"\" loading=\"lazy\" decoding=\"async\"  > <\/picture><figcaption class=\"wp-element-caption\">\u9019\u500b\u8102\u80aa\u6a21\u578b\u76f8\u7576\u65bc5\u78c5\u91cd\u8102\u80aa\uff0c\u8881\u7f8e\u6b23\u6307\u6e1b\u80a5\u4eba\u58eb\u4e0d\u8981\u770b\u8f155\u78c5\u9ad4\u91cd\u7684\u4e0b\u964d\u3002\uff08\u5f6d\u5826\u741b\u651d\uff09<\/figcaption><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-cyan-bluish-gray-color has-alpha-channel-opacity has-cyan-bluish-gray-background-color has-background is-style-wide\"\/>\n\n\n\n<p><\/p>\n\n\n\n<p>\u76f8\u95dc\u95b2\u8b80\uff1a<a href=\"\/\/www.afterroberto.com\/%e6%b8%9b%e8%82%a5-%e7%a9%ba%e8%85%b9%e9%81%8b%e5%8b%95%e6%9b%b4%e6%b6%88%e8%84%82-%e9%81%8b%e5%8b%95%e5%be%8c%e9%80%b2%e9%a3%9f%e6%98%93%e8%87%b4%e8%82%a5\/\" target=\"_blank\" data-type=\"link\" data-id=\"\/\/www.afterroberto.com\/%e6%b8%9b%e8%82%a5-%e7%a9%ba%e8%85%b9%e9%81%8b%e5%8b%95%e6%9b%b4%e6%b6%88%e8%84%82-%e9%81%8b%e5%8b%95%e5%be%8c%e9%80%b2%e9%a3%9f%e6%98%93%e8%87%b4%e8%82%a5\/\" rel=\"noreferrer noopener\">\u3010\u6e1b\u80a5\u3011\u7a7a\u8179\u904b\u52d5\u66f4\u6d88\u8102\uff1f\u904b\u52d5\u5f8c\u9032\u98df\u6613\u81f4\u80a5\uff1f\u71b1\u91cf\u8d64\u5b57\u662f\u4ec0\u9ebc\uff1f<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-cyan-bluish-gray-color has-alpha-channel-opacity has-cyan-bluish-gray-background-color has-background is-style-wide\"\/>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u4e0d\u540c\u8178\u9053\u83cc\u7fa4\u5f71\u97ff\u80a5\u7626 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class=\"wp-block-separator has-text-color has-cyan-bluish-gray-color has-alpha-channel-opacity has-cyan-bluish-gray-background-color has-background is-style-wide\"\/>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u6539\u8b8a\u8102\u80aa\u5b9a\u4f4d 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class=\"wp-block-image size-full\"><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d6c2bf210c3947c582d7d2ca20cd5f38.webp 657w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d6c2bf210c3947c582d7d2ca20cd5f38-300x204.webp 300w,\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d6c2bf210c3947c582d7d2ca20cd5f38-150x102.webp 150w\" sizes=\"(max-width: 657px) 100vw, 657px\" type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d6c2bf210c3947c582d7d2ca20cd5f38.jpg\" height=\"446\" width=\"657\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d6c2bf210c3947c582d7d2ca20cd5f38.jpg 657w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d6c2bf210c3947c582d7d2ca20cd5f38-300x204.jpg 300w, \/\/www.afterroberto.com\/wp-content\/uploads\/2024\/11\/d6c2bf210c3947c582d7d2ca20cd5f38-150x102.jpg 150w\" sizes=\"(max-width: 657px) 100vw, 657px\" class=\"wp-image-48479 sp-no-webp\" alt=\"\" loading=\"lazy\" decoding=\"async\"  > <\/picture><figcaption class=\"wp-element-caption\">\u8981\u9577\u9060\u6539\u8b8a\u8102\u80aa\u5b9a\u4f4d\uff0c\u5fc5\u9808\u4fdd\u6301\u5065\u5eb7\u751f\u6d3b\u7fd2\u6163\uff0c\u5305\u62ec\u6046\u5e38\u904b\u52d5\u3001\u5747\u8861\u98f2\u98df\u3002\uff08Edwin Tan@iStockphoto\uff09<\/figcaption><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>\u6587\uff1a\u5f6d\u5826\u741b<\/p>\n\n\n\n<p>\u7de8\u8f2f\uff1a\u6881\u5c0f\u73b2<\/p>\n\n\n\n<p>\u7f8e\u8853\uff1a\u8b1d\u5049\u8c6a<\/p>\n\n\n\n<p>facebook @\u660e\u5831\u526f\u520a<\/p>\n\n\n\n<p>\u660e\u5831\u5065\u5eb7\u7db2\uff1a<a href=\"\/\/www.afterroberto.com\" target=\"_blank\" data-type=\"link\" data-id=\"www.afterroberto.com\" rel=\"noreferrer noopener\">www.afterroberto.com<\/a><\/p>\n\n\n\n<p>\u96fb\u90f5\uff1a<a href=\"feature@mingpao.com\" target=\"_blank\" data-type=\"link\" data-id=\"feature@mingpao.com\" rel=\"noreferrer 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\u6709\u4eba\u5929\u751f\u300c\u7626\u5e95\u300d\uff0c\u6709\u4eba\u537b\u662f\u300c\u80a5\u5e95\u300d\uff0c\u5176\u5be6\u8207\u8102\u80aa\u5b9a\u4f4d\u6709\u95dc\u3002\u8881\u7f8e\u6b23\u89e3\u91cb\uff0c\u8102\u80aa\u5b9a\u4f4d\u7684\u8a2d\u7f6e\u9ede\u4f4d\u65bc\u4e0b\u4e18\u8166\uff08hypothalamus\uff09\uff0c\u900f\u904e\u4e0b\u4e18\u8166\u5411\u8eab\u9ad4\u767c\u51fa\u4fe1\u865f\u6216\u8377\u723e\u8499\u5206\u6ccc\u7b49\u65b9\u5f0f\uff0c\u8b93\u9ad4\u91cd\u7dad\u6301\u6046\u5b9a\u72c0\u614b\u3002\u300c\u8102\u80aa\u5b9a\u4f4d\u7684\u539f\u7406\uff0c\u5c31\u50cf\u4eba\u9ad4\u81ea\u52d5\u8abf\u7bc0\u9ad4\u6eab\u4e00\u6a23\uff0c\u7576\u611f\u5230\u5bd2\u51b7\uff0c\u6211\u5011\u6703\u4e0d\u81ea\u89ba\u6296\u986b\uff0c\u5f9e\u800c\u8b93\u9ad4\u6eab\u56de\u5347\u3002\u76f8\u53cd\uff0c\u592a\u71b1\u6642\u6703\u81ea\u52d5\u6392\u6c57\u4f7f\u9ad4\u6eab\u4e0b\u964d\u3002\u300d 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3\u500b\u5148\u5929\u56e0\u7d20\u5f71\u97ff\u8102\u80aa\u5b9a\u4f4d \u81f3\u65bc\u8102\u80aa\u5b9a\u4f4d\u7684\u8a2d\u5b9a\uff0c\u7a76\u7adf\u662f\u5148\u5929\u9084\u662f\u5f8c\u5929\uff1f\u300c\u80a5\u80d6\u5728\u57fa\u56e0\u4e0a\u6709\u7740\u907a\u50b3\uff0c\u4f46\u7531\u65bc\u57fa\u56e0\u907a\u50b3\u7684\u96a8\u6a5f\u6027\u5927\uff0c\u82e5\u7236\u6bcd\u4e00\u80a5\u4e00\u7626\uff0c\u5b50\u5973\u6709\u4e00\u534a\u6a5f\u7387\u53ef\u80fd\u662f\u300e\u80a5\u5e95\u300f\u3002\u300d\u8881\u7f8e\u6b23\u8aaa\uff0c\u73fe\u6642\u6c92\u7814\u7a76\u7d71\u8a08\u907a\u50b3\u56e0\u7d20\u6709\u591a\u5927\u7a0b\u5ea6\u5c0e\u81f4\u80a5\u80d6\uff0c\u7136\u800c\u5148\u5929\u5f71\u97ff\u8102\u80aa\u5b9a\u4f4d\u6709\u4ee5\u4e0b\u56e0\u7d20\u3002 1. \u907a\u50b3\u57fa\u56e0 \u9664\u4e86\u7236\u6bcd\u57fa\u56e0\u7684\u907a\u50b3\u6307\u4ee4\u5916\uff0c\u76ee\u524d\u5df2\u767c\u73fe\u903e200\u7a2e\u57fa\u56e0\u8207\u80a5\u80d6\u76f8\u95dc\uff0c\u4ee5\u6700\u5e38\u8ac7\u53ca\u7684\u9ed1\u7d20\u76ae\u8cea\u7d20\u53d7\u9ad44\uff08melanocortin-4 receptor\uff0c\u7c21\u7a31MC4R\uff09\u70ba\u4f8b\uff0cMC4R\u904b\u4f5c\u65bc\u4e0b\u4e18\u8166\uff0cMC4R\u8b8a\u7570\u6703\u4ee4\u5927\u8166\u7121\u6cd5\u611f\u77e5\u6291\u5236\u98df\u617e\u7684\u4fe1\u865f\uff0c\u56e0\u6b64\u5931\u53bb\u98fd\u8db3\u611f\u800c\u8b8a\u5f97\u55dc\u98df\u81f4\u80a5\u30022018\u5e74\u767c\u8868\u65bcNature Genetics\u7684\u7814\u7a76\u66f4\u6307\u51fa\uff0cMC4R\u548cKSR2\uff08kinase suppressor of ras 2\uff09\u7a81\u8b8a\u6703\u5c0e\u81f4\u6975\u5ea6\u80a5\u80d6\u3002\u7528\u65bcMC4R\u8b8a\u7570\u800c\u5c0e\u81f4\u80a5\u80d6\u75c7\u7684\u85e5\u7269\u5df2\u7372\u6b50\u7f8e\u5be9\u6279\u3002 MC4R\u8b8a\u7570\u800c\u5c0e\u81f4\u7684\u80a5\u80d6\u75c7\u5e38\u898b\u65bc\u5b69\u7ae5\u6642\u671f\uff0c\u82e5\u6210\u5e74\u6642\u624d\u767c\u80d6\uff0c\u5f80\u5f80\u4e0d\u662f\u55ae\u4e00\u57fa\u56e0\u8b8a\u7570\uff0c\u53ef\u80fd\u662f\u591a\u57fa\u56e0\u8b8a\u7570\u548c\u5f8c\u5929\u4e0d\u826f\u751f\u6d3b\u7fd2\u6163\u800c\u5c0e\u81f4\uff0c\u9019\u5c31\u8981\u900f\u904e\u6539\u5584\u751f\u6d3b\u7fd2\u6163\u6e1b\u80a5\uff0c\u60c5\u51b5\u56b4\u91cd\u8005\u6216\u9700\u8981\u8655\u65b9\u6e1b\u80a5\u85e5\uff0c\u751a\u81f3\u63a5\u53d7\u7e2e\u80c3\u624b\u8853\u3002 \u6bcd\u4e73\u9935\u54fa\u5b30\u5152\u4e0d\u6613\u80a5 2. \u8868\u89c0\u907a\u50b3\u5b78\uff08epigenetics\uff09 \u8868\u89c0\u907a\u50b3\u80fd\u900f\u904e\u6bcd\u9ad4\u884c\u70ba\u548c\u74b0\u5883\u5f71\u97ff\u57fa\u56e0\u8868\u73fe\uff0c\u8209\u4f8b\u8aaa\uff0c\u7814\u7a76\u5df2\u78ba\u8a8d\u6bcd\u9ad4\u5728\u61f7\u5b55\u671f\u9593\u651d\u53d6\u5927\u91cf\u8102\u80aa\u6703\u4ee4\u80ce\u5152\u300c\u80a5\u80d6\u300d\u3002\u8868\u89c0\u907a\u50b3\u8b93\u5b55\u5a66\u900f\u904e\u98f2\u98df\u8207\u751f\u6d3b\u7fd2\u6163\uff0c\u5f71\u97ff\u80ce\u5152\u5065\u5eb7\u3002\u82e5\u60f3\u70ba\u80ce\u5152\u6253\u4e0b\u5148\u5929\u826f\u597d\u57fa\u790e\uff0c\u5b55\u5a66\u61c9\u7dad\u6301\u5065\u5eb7\u98f2\u98df\u8207\u591a\u505a\u904b\u52d5\uff1b\u53e6\u5916\uff0c\u61c9\u907f\u514d\u904e\u5ea6\u9032\u88dc\u800c\u5c0e\u81f4\u9ad4\u91cd\u6025\u5287\u4e0a\u5347\uff0c\u4ea6\u61c9\u591a\u7559\u610f\u8840\u7cd6\u6307\u6578\uff0c\u907f\u514d\u60a3\u4e0a\u598a\u5a20\u7cd6\u5c3f\u75c5\uff0c\u4ee5\u6e1b\u5c11\u80ce\u5152\u65e5\u5f8c\u60a3\u4e0a\u80a5\u80d6\u75c7\u98a8\u96aa\u3002 3. \u57fa\u56e0\u7d44\u5370\u8a18\uff08genomic imprinting\uff09 \u57fa\u56e0\u7d44\u5370\u8a18\u662f\u4e00\u7a2e\u8868\u89c0\u907a\u50b3\u73fe\u8c61\uff0c\u610f\u6307\u4f86\u81ea\u7236\u7cfb\u6216\u6bcd\u7cfb\u7684\u7279\u5b9a\u57fa\u56e0\uff0c\u5177\u6709\u4e0d\u540c\u6d3b\u6027\uff0c\u800c\u5176\u4e2d\u4e00\u65b9\u57fa\u56e0\u51fa\u73fe\u8b8a\u5316\u88ab\u300c\u6a19\u8a18\u300d\u5f8c\uff0c\u907a\u50b3\u7d66\u5f8c\u4ee3\u3002\u5c0f\u80d6\u5a01\u5229\u7d9c\u5408\u5fb5\uff08Prader-Willi syndrome\uff09\u4fbf\u662f\u5176\u4e2d\u4e00\u4f8b\uff0c\u767c\u75c5\u5176\u4e2d\u4e00\u500b\u539f\u56e0\u662f\u4f86\u81ea\u7236\u89aa\u7b2c15\u689d\u67d3\u8272\u9ad4\u9577\u81c2\u529f\u80fd\u55aa\u5931\uff0c\u800c\u5c0e\u81f4\u7684\u907a\u50b3\u75be\u75c5\uff0c\u6703\u4ee4\u60a3\u8005\u55aa\u5931\u98fd\u809a\u611f\u89ba\u800c\u4e0d\u53d7\u63a7\u5730\u9032\u98df\uff0c\u7d42\u5f15\u767c\u56b4\u91cd\u80a5\u80d6\u75c7\u3002 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