{"id":42402,"date":"2023-07-25T17:33:08","date_gmt":"2023-07-25T09:33:08","guid":{"rendered":"\/\/www.afterroberto.com\/?p=41928"},"modified":"2023-08-03T09:59:45","modified_gmt":"2023-08-03T01:59:45","slug":"%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%e6%96%b0%e8%97%a5-%e5%88%9d%e6%9c%9f%e6%82%a3%e8%80%85%e8%aa%8d%e7%9f%a5%e9%80%80%e5%8c%96%e6%b8%9b%e6%85%a260-%e5%89%af%e4%bd%9c%e7%94%a8%e6%88%96","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%e6%96%b0%e8%97%a5-%e5%88%9d%e6%9c%9f%e6%82%a3%e8%80%85%e8%aa%8d%e7%9f%a5%e9%80%80%e5%8c%96%e6%b8%9b%e6%85%a260-%e5%89%af%e4%bd%9c%e7%94%a8%e6%88%96\/","title":{"rendered":"\u963f\u8332\u6d77\u9ed8\u75c7\u65b0\u85e5 \u521d\u671f\u60a3\u8005\u8a8d\u77e5\u9000\u5316\u6e1b\u616260%  \u526f\u4f5c\u7528\u6216\u5f15\u767c\u8166\u816b\u8139\u3001\u8166\u51fa\u8840\u60f9\u7591"},"content":{"rendered":"\n<figure class=\"wp-block-image size-full\"><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2023\/07\/Screenshot-2023-07-25-170247.webp \"  type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2023\/07\/Screenshot-2023-07-25-170247.png\" class=\"wp-image-41929 sp-no-webp\" alt=\"\" decoding=\"async\"  > <\/picture><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u7f8e\u570b\u85e5\u5ee0\u79ae\u4f86\uff08Eli Lilly\uff0917\u65e5\u767c\u8868<a href=\"\/\/www.afterroberto.com\/%e8%aa%8d%e7%9f%a5%e9%9a%9c%e7%a4%99%e7%97%87-%e5%81%b5%e6%b8%ac%e6%82%a3%e9%98%bf%e8%8c%b2%e6%b5%b7%e9%bb%98%e7%97%87%e9%a2%a8%e9%9a%aa-2%e5%88%86%e9%90%98%e5%88%86%e6%9e%90%e7%9c%bc%e5%ba%95\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u963f\u8332\u6d77\u9ed8\u75c7<\/a>\u65b0\u85e5donanemab\u7684\u6700\u7d42\u81e8\u7240\u5be6\u9a57\u5168\u9762\u5206\u6790\u5831\u544a\u3002\u7576\u4e2d\u986f\u793a\u6b64\u85e5\u7e31\u672a\u898b\u53ef\u4ee5\u6539\u5584\u75c5\u5fb5\uff0c\u4f46\u6574\u9ad4\u800c\u8a00\u5728\u5e74\u534a\u671f\u9593\u80fd\u8b93\u60a3\u8005\u7684\u8166\u90e8\u9000\u5316\u901f\u5ea6\u6e1b\u7de9\u4e8635%\uff0c\u800c\u5c0d\u65bc75\u6b72\u4ee5\u4e0b\u521d\u671f\u60a3\u8005\u7684\u6e1b\u6162\u8870\u9000\u901f\u5ea6\u6548\u679c\u66f4\u9ad8\u905460%\u3002donanemab\u662f\u7b2c\u4e8c\u6b3e\u8b49\u660e\u80fd\u6e1b\u7de9\u8a8d\u77e5\u8870\u9000\u7684\u963f\u8332\u6d77\u9ed8\u75c7\u985e\u6fb1\u7c89\u86cb\u767d\u6a19\u9776\u85e5\u7269\uff0c\u6548\u679c\u4f3c\u7a0d\u52dd\u524d\u53e6\u4e00\u6b3e\u85e5\u7269lecanemab\u3002\u6709\u5c08\u5bb6\u8a8d\u70ba\u9019\u662f\u91cc\u7a0b\u7891\uff0c\u4e0d\u904e\u6b64\u85e5\u53ef\u80fd\u5f15\u767c\u7684\u8166\u816b\u8139\u3001\u8166\u51fa\u8840\u60c5\u51b5\uff0c\u4ecd\u60f9\u4e00\u4e9b\u4eba\u7591\u616e\u3002<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u963f\u8332\u6d77\u9ed8\u75c7\u65b0\u85e5Donanemab \u8a8d\u77e5\u9000\u5316\u6e1b\u616260%&nbsp; \u8166\u816b\u51fa\u8840\u526f\u4f5c\u7528\u60f9\u7591\u616e<\/strong><\/h2>\n\n\n\n<p>Donanemab\u662f\u4e00\u7a2e\u514d\u75ab\u7403\u86cb\u767dG1\u55ae\u514b\u9686\u6297\u9ad4\u85e5\u7269\uff0c\u5c08\u91dd\u5c0d\u963f\u8332\u6d77\u9ed8\u75c7\u5176\u4e00\u6210\u56e0\uff1a\u50c5\u5b58\u65bc\u8166\u90e8\u300c\u985e\u6fb1\u7c89\u86cb\u767d\u6591\u584a\u300d\uff08amyloid plaques\uff09\u4e2d\u7684\u7279\u5b9a\u300c\u03b2\u985e\u6fb1\u7c89\u86cb\u767d\u300d\u3002\u985e\u6fb1\u7c89\u86cb\u767d\u6591\u584a\u5728\u795e\u7d93\u5143\u4e4b\u9593\u7a4d\u805a\uff0c\u6703\u963b\u7919\u795e\u7d93\u7d30\u80de\u767c\u63ee\u6b63\u5e38\u529f\u80fd\uff0cdonanemab\u80fd\u6307\u4f7f\u6297\u9ad4\u7d91\u7d81\u65bc\u300c\u6591\u584a\u300d\uff0c\u523a\u6fc0\u514d\u75ab\u7d30\u80de\u6e05\u9664\u985e\u6fb1\u7c89\u86cb\u767d\uff08\u5716\uff09\u3002\u6d89\u53ca8\u500b\u570b\u5bb6\u5408\u8a081736\u540d60\u6b72\u81f385\u6b72\u3001\u5e73\u5747\u5e74\u9f6173\u6b72\u7684\u521d\u671f\u7f79\u60a3\u963f\u8332\u6d77\u9ed8\u75c7\u6216\u8f15\u5ea6<a href=\"\/\/www.afterroberto.com\/%e8%aa%8d%e7%9f%a5%e9%9a%9c%e7%a4%99%e7%97%87-%e7%85%a7%e9%a1%a7%e8%80%85%e8%88%87%e8%aa%8d%e7%9f%a5%e9%9a%9c%e7%a4%99%e7%97%87%e6%82%a3%e8%80%85%e5%90%8c%e8%a1%8c-%e7%95%99%e6%84%8f%e7%95%b0%e5%b8%b8\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u8a8d\u77e5\u969c\u7919<\/a>\uff08MCI\uff09\u60a3\u8005\uff0c\u53c3\u8207\u4e86\u78ba\u8a8d\u5176\u7642\u6548\u8207\u5b89\u5168\u7684\u6700\u5f8c\u81e8\u7240\u5be6\u9a57\u3002\u7576\u4e2d\u4e94\u6210\u4eba\u572876\u500b\u661f\u671f\uff08\u903e\u4e00\u5e74\u534a\uff09\u5167\u6bcf\u6708\u63a5\u53d7\u6ce8\u5c04\u4e00\u6b21donanemab\uff0c\u9918\u4e0b\u4e94\u6210\u4eba\u7372\u5b89\u6170\u5291\u505a\u5c0d\u7167\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2023\/07\/268fc8dcc22e90447d8f51d66323ec6f.webp \"  type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2023\/07\/268fc8dcc22e90447d8f51d66323ec6f.jpg\" class=\"wp-image-41930 sp-no-webp\" alt=\"\" decoding=\"async\"  > <\/picture><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-cyan-bluish-gray-color has-alpha-channel-opacity has-cyan-bluish-gray-background-color has-background 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class=\"wp-block-heading\"><strong>\u8fd1\u534a\u7528\u5bb6\u4e00\u5e74\u7121\u60e1\u5316<\/strong><\/h2>\n\n\n\n<p>\u8a72\u5be6\u9a57\u7684\u5168\u9762\u5206\u6790\u5831\u544a17\u65e5\u520a\u65bc\u7f8e\u570b\u91ab\u5b78\u6703\u671f\u520a\uff08JAMA\uff09\u3002\u5206\u6790\u986f\u793a\uff0c\u8a66\u7528\u65b0\u85e5\u7684\u60a3\u8005\uff0c47%\u5728\u4e00\u5e74\u5f8c\u6c92\u6709\u75c5\u60c5\u60e1\u5316\uff08\u6bd4\u7167\u7d44\u670929%\uff09\uff0c\u53ef\u4f7f\u4ed6\u5011\u7684\u8a18\u61b6\u53ca\u601d\u7dad\u8870\u9000\u8f03\u5c0d\u7167\u7d44\u62d6\u6162\u7d044\u500b\u534a\u6708\u81f37\u500b\u534a\u6708\u3002\u6574\u9ad4\u800c\u8a00\uff0c\u65b0\u85e5\u53ef\u4f7f\u8166\u9000\u5316\u901f\u5ea6\u6e1b\u6162\u7d0435%\u3002\u5c0d\u65bc\u672a\u6eff75\u6b72\u7684\u8f15\u5ea6\u60a3\u8005\uff0c\u6548\u679c\u66f4\u986f\u8457\u905460%\u3002\u6e2c\u91cf\u65b9\u5f0f\u662f\u4ee5\u300c\u7d9c\u5408\u963f\u8332\u6d77\u9ed8\u75c7\u91cf\u8868\u300d\uff08iADRS\uff09\u70ba\u6a19\u6e96\uff0c\u8a55\u4f30\u60a3\u8005\u57f7\u884c\u65e5\u5e38\u4e8b\u52d9\u7684\u80fd\u529b\uff0c\u50cf\u662f\u7ba1\u7406\u8ca1\u52d9\u3001\u99d5\u99db\u6c7d\u8eca\u3001\u5f9e\u4e8b\u55dc\u597d\uff0c\u4ee5\u53ca\u8ac7\u8ad6\u6642\u4e8b\u7b49\u3002\u53e6\u5916\u8166\u90e8\u6383\u63cf\u986f\u793a\uff0c\u6b64\u85e5\u80fd\u5728\u7528\u85e5\u4e00\u5e74\u5167\u6e05\u9664\u8166\u5167\u7d04\u4e5d\u6210\u7684\u985e\u6fb1\u7c89\u86cb\u767d\uff0c\u4e4b\u5f8c\u534a\u5e74\u7121\u518d\u91cd\u73fe\u3002\u5831\u544a\u8a8d\u70ba\uff0c\u60a3\u8005\u53ef\u80fd\u6bcb\u9808\u7d42\u8eab\u6bcf\u6708\u975c\u8108\u6ce8\u5c04\u3002<\/p>\n\n\n\n<p>\u8ddf\u963f\u8332\u6d77\u9ed8\u75c7\u85e5\u7269\u7814\u7a76\u7121\u95dc\u7684\u7f8e\u570b\u54c8\u4f5b\u5927\u5b78\u91ab\u5b78\u9662\u795e\u7d93\u79d1\u91ab\u751f\u65af\u73c0\u6797\uff08Reisa Sperling\uff09\u8868\u793a\uff0cdonanemab\u53ca\u985e\u4f3c\u85e5\u7269lecanemab\u7684\u5be6\u9a57\u7d50\u679c\u300c\u975e\u5e38\u4f7f\u4eba\u9f13\u821e\u300d\uff0c\u8a8d\u70ba\u7814\u7a76\u8d70\u5c0d\u4e86\u65b9\u5411\u3002\u82f1\u570b\u6148\u5584\u7d44\u7e54\u963f\u8332\u6d77\u9ed8\u75c7\u7814\u7a76\u6240\u7684\u526f\u7e3d\u76e3\u5967\u514b\u5229\uff08Richard Oakley\uff09\u6307\u51fa\uff0c\u904e\u53bb\u6578\u5341\u5e74\u7814\u7a76\u6beb\u7121\u5bf8\u9032\uff0c\u8fd18\u500b\u6708\u767c\u8868\u7684\u6b64\u5169\u85e5\u7814\u7a76\u767c\u73fe\u624d\u986f\u793a\u8f49\u6a5f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2023\/07\/268fd2e79d7c611ae0e738d01036597b-790x1024.jpg\" alt=\"\" class=\"wp-image-41931\" title=\"\"><\/figure>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>donanemab\u53calecanemab\u5169\u85e5\u50c5\u62d6\u6162\u75c5\u60c5 \u5c08\u5bb6\u6307\u81e8\u7240\u5be6\u9a57\u6709\u56b4\u91cd\u526f\u4f5c\u7528<\/strong><\/h2>\n\n\n\n<p>\u4e0d\u904e\uff0c\u5169\u85e5\u53ea\u662f\u62d6\u6162\u963f\u8332\u6d77\u9ed8\u75c7\u75c5\u60c5\u767c\u5c55\u800c\u4e0d\u5177\u6cbb\u7652\u3001\u4fee\u5fa9\u8166\u640d\u50b7\u529f\u6548\uff0c\u9810\u9632\u80fd\u529b\u4ea6\u5f85\u7814\u7a76\u3002\u5b83\u5011\u5c0d\u5176\u4ed6\u985e\u578b\u7684\u8166\u9000\u5316\u75c7\u7121\u6548\uff0c\u4f8b\u5982\u8840\u7ba1\u6027\u5931\u667a\u75c7\u3002\u6b64\u5916\uff0c\u5169\u85e5\u7684\u81e8\u7240\u5be6\u9a57\u7686\u986f\u793a\u6709\u56b4\u91cd\u526f\u4f5c\u7528\u8166\u816b\u8139\u3001\u8166\u51fa\u8840\uff0c\u4e26\u5404\u67093\u4eba\u6b7b\u4ea1\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2023\/07\/268fe31bbfbd6d1384209fb9f2d76d94.webp \"  type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2023\/07\/268fe31bbfbd6d1384209fb9f2d76d94.jpg\" class=\"wp-image-41932 sp-no-webp\" alt=\"\" decoding=\"async\"  > <\/picture><figcaption class=\"wp-element-caption\">\u9019\u662f76\u5468\u81e8\u7240\u5be6\u9a57\u5167\uff0c\u6383\u63cf\u986f\u793a\u7528\u85e5\u75c5\u4eba\uff08\u4e0a\u6392\uff09\u8207\u7121\u7528\u85e5\u5c0d\u7167\u7d44\u75c5\u4eba\uff08\u4e0b\u6392\uff09\u7684\u8166\u5167\u985e\u6fb1\u7c89\u86cb\u767d\u6591\u584a\uff08\u7da0\u9ec3\u7d05\u90e8\u5206\uff09\u8b8a\u5316\u6bd4\u8f03\u7167\u7247\uff0c\u53ef\u898b\u7528\u85e5\u75c5\u4eba\u7684\u6591\u584a\u986f\u8457\u6e1b\u5c11\u3002\uff08\u7db2\u4e0a\u5716\u7247\uff09<\/figcaption><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-cyan-bluish-gray-color has-alpha-channel-opacity has-cyan-bluish-gray-background-color has-background is-style-wide\"\/>\n\n\n\n<p>\u76f8\u95dc\u95b2\u8b80\uff1a<a href=\"\/\/www.afterroberto.com\/%e8%aa%8d%e7%9f%a5%e9%9a%9c%e7%a4%99%e7%97%87-%e7%85%a7%e9%a1%a7%e8%80%85%e8%88%87%e8%aa%8d%e7%9f%a5%e9%9a%9c%e7%a4%99%e7%97%87%e6%82%a3%e8%80%85%e5%90%8c%e8%a1%8c-%e7%95%99%e6%84%8f%e7%95%b0%e5%b8%b8\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u3010\u8a8d\u77e5\u969c\u7919\u75c7\u3011\u7167\u9867\u8005\u8207\u8a8d\u77e5\u969c\u7919\u75c7\u60a3\u8005\u540c\u884c \u7559\u610f\u7570\u5e38\u8209\u52d5\u5efa\u7acb\u5065\u5eb7\u751f\u6d3b \u6f2b\u9577\u904e\u7a0b\u7167\u9867\u8005\u52ff\u81ea\u8cac\u611b\u81ea\u5df1\u591a\u4e00\u4e9b<\/a><\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-cyan-bluish-gray-color has-alpha-channel-opacity has-cyan-bluish-gray-background-color has-background is-style-wide\"\/>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>\u7f8e\u6700\u5feb\u5e74\u5e95\u51c6\u7528<\/strong><\/h2>\n\n\n\n<p>\u54e5\u502b\u6bd4\u4e9e\u5927\u5b78\u6b50\u6587\u91ab\u5b78\u4e2d\u5fc3\u795e\u7d93\u5167\u79d1\u5c08\u5bb6\u66fc\u5229\uff08Jennifer Manly\uff09\u548c\u52a0\u5dde\u5927\u5b78\u6d1b\u6749\u78ef\u5206\u6821\u7684\u5fb7\u7279\u65af\uff08Kacie 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