{"id":38495,"date":"2022-06-27T17:15:54","date_gmt":"2022-06-27T09:15:54","guid":{"rendered":"\/\/www.afterroberto.com\/?p=38495"},"modified":"2022-06-27T17:16:08","modified_gmt":"2022-06-27T09:16:08","slug":"%e7%9b%b4%e8%85%b8%e7%99%8c%e6%82%a3%e8%80%85%e5%8d%8a%e5%b9%b4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%99%82-%e8%85%ab%e7%98%a4100%e6%b6%88%e5%a4%b1-%e6%b8%9b%e5%82%b3%e7%b5%b1%e7%99%82%e6%b3%95%e5%be%8c","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e7%9b%b4%e8%85%b8%e7%99%8c%e6%82%a3%e8%80%85%e5%8d%8a%e5%b9%b4%e5%85%8d%e7%96%ab%e6%b2%bb%e7%99%82-%e8%85%ab%e7%98%a4100%e6%b6%88%e5%a4%b1-%e6%b8%9b%e5%82%b3%e7%b5%b1%e7%99%82%e6%b3%95%e5%be%8c\/","title":{"rendered":"\u3010\u76f4\u8178\u764c\u3011\u7814\u7a76\uff1a\u76f4\u8178\u764c\u60a3\u8005\u534a\u5e74\u514d\u75ab\u6cbb\u7642 \u816b\u7624100%\u6d88\u5931 \u6e1b\u50b3\u7d71\u7642\u6cd5\u5f8c\u907a\u75c7 \u5fa9\u767c\u53ca\u9577\u671f\u6cbb\u7652\u7387\u672a\u77e5\u4e4b\u6578"},"content":{"rendered":"\n

\u3010\u660e\u5831\u5c08\u8a0a\u3011\u672c\u6708\u521d\uff0c\u570b\u969b\u9802\u5c16\u91ab\u5b78\u671f\u520a\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u767c\u8868\u4e00\u7bc7\u76f4\u8178\u764c<\/a>\u7814\u7a76\u5831\u544a\uff0c\u5f15\u8d77\u5ee3\u6cdb\u8a0e\u8ad6\u3002\u7814\u7a76\u53ea\u5305\u542b12\u540d\u75c5\u4eba\uff0c\u6578\u64da\u4e5f\u5f88\u521d\u6b65\uff0c\u8ffd\u8e64\u6642\u95936\u81f325\u500b\u6708\uff0c\u70ba\u4f55\u51fa\u73fe\u5ee3\u6cdb\u8ff4\u97ff\u5462\uff1f\u56e0\u70ba\u7814\u7a76\u7d50\u679c\u5be6\u5728\u592a\u9707\u64bc\uff0c\u5168\u90e812\u540d\u4e2d\u665a\u671f\u76f4\u8178\u764c\u75c5\u4eba\uff0c\u5b8c\u6210\u70ba\u671f\u534a\u5e74\u514d\u75ab\u6cbb\u7642\u5f8c\uff0c\u6240\u6709\u60a3\u8005\uff08100%\uff09\u7684\u816b\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u75c5\u4eba\u6bcb\u9808\u505a\u624b\u8853\u3001\u5316\u7642\u6216\u96fb\u7642\u3002<\/p>\n\n\n\n\n\n\n\n

\u76f4\u8178\u764c\u50b3\u7d71\u7642\u6cd5\u6216\u8981\u5207\u8d70\u809b\u9580 \u624b\u8853\u5f8c\u907a\u75c7\u96e3\u514d<\/strong><\/h2>\n\n\n\n

\u76f4\u8178\u4f4d\u8655\u5927\u8178\u672b\u7aef\uff0c\u9023\u63a5\u809b\u9580\uff0c\u8ca0\u8cac\u6392\u6cc4\u53ca\u6d88\u5316\u7684\u529f\u80fd\u3002\u76f4\u8178\u764c\u65bc\u9999\u6e2f\u8fd1\u5e74\u6709\u4e0a\u5347\u8da8\u52e2\uff0c\u6839\u64da\u9999\u6e2f\u764c\u75c7<\/a>\u8cc7\u6599\u7d71\u8a08\u4e2d\u5fc3\uff0c\u76f4\u8178\u6216\u809b\u9580\u764c\u65b0\u75c7\u4eba\u6578\u75312010\u5e741753\u5b97\u5347\u81f32019\u5e742072\u5b97\uff0c\u5347\u5e45\u8fd1\u5169\u6210\uff1b\u5e73\u5747\u78ba\u8a3a\u5e74\u9f61\u4e2d\u4f4d\u6578\u7d0470\u6b72\u3002<\/p>\n\n\n\n

\u4e00\u76f4\u4ee5\u4f86\uff0c\u624b\u8853\u5207\u9664\u662f\u6839\u6cbb\u76f4\u8178\u764c\u7684\u552f\u4e00\u624b\u6bb5\u3002\u5982\u816b\u7624\u5c6c\u65bc\u4e2d\u665a\u671f\uff0c\u9700\u5148\u7528\u96fb\u7642\u806f\u5408\u5316\u7642\uff0c\u5c07\u816b\u7624\u7e2e\u5c0f\u65b9\u80fd\u5207\u9664\uff1b\u60df\u6cbb\u7642\u7121\u53ef\u907f\u514d\u6703\u5f71\u97ff\u6d88\u5316\u3001\u6ccc\u5c3f\u53ca\u6027\u529f\u80fd\u7b49\u5f8c\u907a\u75c7\u3002\u5982\u679c\u76f4\u8178\u764c\u816b\u7624\u8655\u65bc\u4f4e\u4f4d\uff0c\u63a5\u8fd1\u809b\u9580\u4f4d\u7f6e\uff0c\u75c5\u4eba\u66f4\u53ef\u80fd\u7121\u6cd5\u4fdd\u7559\u809b\u9580\uff0c\u9700\u8981\u4eba\u5de5\u9020\u53e3\uff08\u4fd7\u7a31\u5c4e\u888b\uff09\u3002\u6545\u8fd1\u5e74\u76f4\u8178\u764c\u7814\u7a76\u65b9\u5411\u4e00\u76f4\u5faa\u907f\u514d\u624b\u8853\u70ba\u4e3b\u8ef8\u3002\u4f8b\u5982\u4f7f\u7528\u8fd1\u63a5\u96fb\u7642\uff08brachytherapy\uff09\uff0c\u5373\u8f3b\u5c04\u7dda\u76f4\u63a5\u63a5\u89f8\u816b\u7624\u8868\u9762\uff0c\u8fd1\u8ddd\u96e2\u91cb\u51fa\u9ad8\u5291\u91cf\u8f3b\u5c04\u6bba\u6b7b\u764c\u7d30\u80de\uff1b\u6216\u96fb\u7642\u5316\u7642\u5f8c\u63a1\u53d6\u89c0\u5bdf\u65b9\u6848\uff08watch-and-wait approach\uff09\uff0c\u7686\u662f\u5e0c\u671b\u9054\u5230\u6839\u6cbb\u4e4b\u9918\uff0c\u75c5\u4eba\u80fd\u907f\u514d\u627f\u53d7\u624b\u8853\u5f8c\u907a\u75c7\u4e4b\u82e6\u3002<\/p>\n\n\n\n

\"\" <\/picture>
\u9707\u64bc\u7814\u7a76\u2014\u2014\u300a\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\u300b\u767c\u8868\u4e00\u7bc7\u5831\u544a\uff0c\u6307\u5168\u90e812\u540d\u53c3\u8207\u7814\u7a76\u7684\u4e2d\u665a\u671f\u76f4\u8178\u764c\u75c5\u4eba\uff0c\u5b8c\u6210\u70ba\u671f\u534a\u5e74\u514d\u75ab\u6cbb\u7642\u5f8c\uff0c\u816b\u7624\u5b8c\u5168\u6d88\u5931\uff0c\u75c5\u4eba\u6bcb\u9808\u624b\u8853\u3001\u5316\u7642\u6216\u96fb\u7642\u3002\u7814\u7a76\u7d50\u679c\u9707\u64bc\u91ab\u5b78\u754c\u3002\uff08\u8a2d\u8a08\u5716\u7247\uff0cyodiyim@iStockphoto\/\u660e\u5831\u88fd\u5716\uff09<\/figcaption><\/figure><\/div>\n\n\n\n\n\n\n\n

\u76f8\u95dc\u6587\u7ae0\uff1a\u91dd\u5c0d\u5927\u8178\u764c\u671f\u6578\u8abf\u6574\u6cbb\u7642\u8a08\u5283 \u53ca\u65e9\u7be9\u67e5\u9810\u9632\u52dd\u6cbb\u7642\uff08\u9644\uff1a\u6ce8\u610f\u5927\u8178\u764c\u5148\u51465\u5927\u5fb5\u72c0\uff09<\/a><\/strong><\/p>\n\n\n\n\n\n\n\n

\u96f6\u624b\u8853\u5316\u7642\u96fb\u7642 \u816b\u7624100%\u6d88\u5931<\/h2>\n\n\n\n

\u81f3\u65bc\u672c\u6708\u521d\u5f15\u767c\u8a0e\u8ad6\u7684\uff0c\u662f\u65bc\u7f8e\u570b\u7684\u300c\u55ae\u4e2d\u5fc3\u55ae\u81c2\u300d\u7814\u7a76\uff0c\u5c0d\u8c61\u70ba\u7b2c\u4e8c\u6216\u4e09\u671f\u76f4\u8178\u764c\u60a3\u8005\u3002\u6240\u6709\u60a3\u8005\u5fc5\u9808\u63a5\u53d7\u75c5\u7406\u6aa2\u67e5\uff0c\u78ba\u5b9a\u816b\u7624\u5c6c\u65bc\u9ad8MSI\uff08\u5fae\u885b\u661f\u4e0d\u7a69\u5b9a\uff0cmicrosatellite instability\uff0c\u8a73\u898b\u300c\u77e5\u591a\u5572\u300d\uff09\u3002MSI\u662f\u514d\u75ab\u6cbb\u7642\u7684\u751f\u7269\u6a19\u8a18\uff08biomarker\uff09\uff0c\u9ad8MSI\u816b\u7624\u60a3\u8005\u82e5\u4f7f\u7528\u514d\u75ab\u6cbb\u7642\uff0c\u6703\u6bd4\u50b3\u7d71\u5316\u7642\u52a0\u6a19\u9776\u85e5\u66f4\u70ba\u6709\u6548\u3002\u7814\u7a76\u4eba\u54e1\u70ba\u60a3\u8005\u65bd\u4e88\u6bcf3\u661f\u671f1\u6b21\u7684\u514d\u75ab\u6291\u5236\u85e5\u7269PD-1\u6291\u5236\u5291\uff0c\u70ba\u671f\u534a\u5e74\u3002<\/p>\n\n\n\n

\u7d50\u679c\u5728\u534a\u5e74\u7642\u7a0b\u88cf\uff0c\u6240\u670912\u540d\u60a3\u8005\uff08100%\uff09\u7684\u816b\u7624\u5747\u65bc\u5167\u7aba\u93e1\u3001\u78c1\u529b\u5171\u632f\u53ca\u6b63\u96fb\u5b50\u6383\u63cf\u6aa2\u67e5\u88cf\u5b8c\u5168\u6d88\u5931\uff1b\u6240\u6709\u75c5\u4eba\u5747\u6bcb\u9808\u63a5\u53d7\u624b\u8853\uff0c\u53c8\u6216\u5316\u7642\u53ca\u96fb\u7642\u8ddf\u9032\uff0c\u6cbb\u7642\u7684\u514d\u75ab\u526f\u4f5c\u7528\u4ea6\u76f8\u5c0d\u6eab\u548c\u3002\u7814\u7a76\u4ecd\u5728\u9032\u884c\u4e2d\uff0c\u8a08\u5283\u62db\u52df30\u540d\u60a3\u8005\u3002<\/p>\n\n\n\n

\"\" <\/picture>
\u816b\u7624\u5207\u9664\u2014\u2014\u624b\u8853\u5207\u9664\u662f\u6839\u6cbb\u76f4\u8178\u764c\u7684\u552f\u4e00\u624b\u6bb5\uff1b\u5982\u816b\u7624\u5c6c\u65bc\u4e2d\u665a\u671f\uff0c\u9700\u7528\u96fb\u7642\u806f\u5408\u5316\u7642\u5148\u5c07\u816b\u7624\u7e2e\u5c0f\uff0c\u65b9\u80fd\u5c07\u816b\u7624\u5207\u9664\u3002\uff08\u8a2d\u8a08\u5716\u7247\uff0c\u6a21\u7279\u5152\u8207\u672c\u6587\u63d0\u53ca\u75be\u75c5\u7121\u95dc\uff0cFatCamera@iStockphoto\uff09<\/figcaption><\/figure><\/div>\n\n\n\n\n\n\n\n

\u5fa9\u767c\u53ca\u9577\u671f\u6cbb\u7652\u7387\u672a\u77e5\u4e4b\u6578<\/h2>\n\n\n\n

\u6b64\u7814\u7a76\u7d50\u679c\u7121\u7591\u662f\u9769\u547d\u7d1a\uff01\u9996\u5148\u3001\u6cbb\u7642\u6709\u6548\u7387100%\uff0c\u6210\u6548\u986f\u8457\uff1b \u7b2c\u4e8c\u3001\u75c5\u4eba\u80fd\u907f\u514d\u627f\u53d7\u624b\u8853\u6216\u96fb\u7642\u5316\u7642\u5f8c\u907a\u75c7\u3002\u4ee5\u514d\u75ab\u6cbb\u7642\u4f5c\u70ba\u6839\u6cbb\u624b\u6bb5\u662f\u5d84\u65b0\u7684\u6cbb\u7642\u7b56\u7565\uff0c\u6709\u671b\u63a8\u5c55\u81f3\u5176\u4ed6\u816b\u7624\u3002\u4f46\u5fc5\u9808\u63d0\u9192\u5927\u5bb6\uff1a<\/p>\n\n\n\n

1. \u53ea\u67095%\u81f310%\u76f4\u8178\u764c\u60a3\u8005\uff0c\u5c6c\u65bc\u9ad8\u5fae\u885b\u661f\u4e0d\u7a69\u5b9a\u816b\u7624\uff1b\u6545\u6b64\uff0c\u9019\u6cbb\u7642\u7b56\u7565\u4e26\u975e\u6240\u6709\u60a3\u8005\u90fd\u9069\u5408\u63a1\u7528<\/p>\n\n\n\n

2. \u6b64\u7814\u7a76\u53ea\u662f\u65bc\u7f8e\u570b\u55ae\u4e2d\u5fc3\u7684\u5c0f\u578b\u7814\u7a76\uff0c\u6545\u6b64100%\u6709\u6548\u7387\u7684\u7d50\u679c\u80fd\u5426\u61c9\u7528\u65bc\u4e0d\u540c\u5730\u5340\u7684\u60a3\u8005\uff0c\u4ecd\u6709\u5f85\u5927\u578b\u7684\u591a\u4e2d\u5fc3\u7814\u7a76\u53bb\u78ba\u8a8d<\/p>\n\n\n\n

3. \u8fc4\u4eca\u53ea\u516c\u5e03\u4e86\u65e9\u671f\u7814\u7a76\u7d50\u679c\uff0c\u6545\u6b64\uff0c\u9577\u671f\u5fa9\u767c\u7387\u53ca\u6cbb\u7652\u7387\uff0c\u4ee5\u53ca\u816b\u7624\u6d88\u5931\u662f\u5426\u4ee3\u8868\u9577\u9060\u6839\u6cbb\u7b49\u554f\u984c\uff0c\u4ecd\u662f\u672a\u77e5\u4e4b\u6578<\/p>\n\n\n\n

\u73fe\u968e\u6bb5\uff0c\u624b\u8853\u5207\u9664\u914d\u5408\u96fb\u7642\u5316\u7642\u4ecd\u662f\u6cbb\u7642\u76f4\u8178\u764c\u7684\u9ec3\u91d1\u6a19\u6e96\u3002\u4f46\u7121\u7591\uff0c\u6b64\u7814\u7a76\u7684\u521d\u6b65\u7d50\u679c\uff0c\u958b\u555f\u4e86\u4ee5\u514d\u75ab\u6cbb\u7642\u4f5c\u70ba\u6839\u6cbb\u624b\u6bb5\u7684\u7814\u7a76\u5927\u9580\uff0c\u4ea6\u70ba\u76f4\u8178\u764c\u75c5\u4eba\u5e36\u4f86\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n\n\n\n

\"\" <\/picture>
\uff08\u660e\u5831\u88fd\u5716\uff09<\/figcaption><\/figure><\/div>\n\n\n\n\n\n\n\n

\u76f8\u95dc\u6587\u7ae0\uff1a\u3010\u672c\u6e2f\u5341\u5927\u5e38\u898b\u764c\u75c7\u3011\u81f4\u547d\u764c\u75c7\u99963\u4f4d\uff1a\u80ba\u764c\u3001\u5927\u8178\u764c\u53ca\u809d\u764c \u6ce8\u610f\u80f0\u81df\u764c\u65b0\u75c710\u5e74\u589e\u4e5d\u6210<\/a><\/strong><\/p>\n\n\n\n\n\n\n\n

\u25a0 \u77e5\u591a\u5572\uff1a\u9ad8MSI\u816b\u7624 \u514d\u75ab\u6cbb\u7642\u66f4\u6709\u6548<\/h2>\n\n\n\n

\u5fae\u885b\u661f\u4e0d\u7a69\u5b9a\uff08microsatellite instability\uff0cMSI\uff09\u816b\u7624\uff0c\u662f\u6307\u5728\u7d30\u80de\u5206\u88c2\u904e\u7a0b\u4e2d\uff0c\u65bc\u4fee\u5fa9\u932f\u8aa4DNA\u5e8f\u5217\u65b9\u9762\u5b58\u5728\u7f3a\u9677\uff08mismatch repair deficiency\uff0cMMR-d\uff09\uff0c\u5f15\u8d77\u5fae\u885b\u661f\u5e8f\u5217\u9577\u5ea6\u6539\u8b8a\u3002\u8a31\u591a\u81e8\u7240\u7814\u7a76\u8b49\u5be6\uff0cMSI\u8207\u591a\u7a2e\u764c\u75c7\u6709\u95dc\uff0c\u7576\u51fa\u73fe\u9ad8\u5fae\u885b\u661f\u4e0d\u7a69\u5b9a\uff08MSI-H\uff09\uff0c\u60a3\u764c\u98a8\u96aa\u6709\u53ef\u80fd\u6703\u589e\u52a0\u3002\u6210\u56e0\u9664\u4e86\u907a\u50b3\u75be\u75c5\u4ee5\u5916\uff0c\u5f8c\u5929\u5076\u767c\u56e0\u7d20\u4ea6\u6703\u5f15\u81f4\u3002<\/p>\n\n\n\n

\u514d\u75ab\u6cbb\u7642\u5c0d\u9ad8MSI\u816b\u7624\u7279\u5225\u6709\u6548\u3002\u7814\u7a76\u53c8\u986f\u793a\uff0c\u65bc\u665a\u671f\u764c\u75c7\u800c\u591a\u7dda\u5316\u7642\u5931\u6548\u7684\u60a3\u8005\uff0c\u7121\u8ad6\u662f\u4efb\u4f55\u985e\u578b\u7684\u5be6\u9ad4\u816b\u7624\uff08solid cancer\uff09\uff0c\u63a1\u7528\u514d\u75ab\u7642\u6cd5\u7684\u6709\u6548\u7387\u90fd\u9ad8\u905430%\u81f340%\u3002\u6545\u6b64\uff0c\u7f8e\u570b\u98df\u54c1\u53ca\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u65e9\u65bc2017\u5e74\u5df2\u6279\u51c6\u514d\u75ab\u6cbb\u7642\u61c9\u7528\u65bc\u5f8c\u671f\u53ca\u591a\u7dda\u5316\u7642\u5931\u6548\u7684\u5fae\u885b\u661f\u4e0d\u7a69\u5b9a\u5be6\u9ad4\u816b\u7624\u3002\u53e6\u5916\uff0c\u7814\u7a76\u4ea6\u8b49\u5be6\u9ad8MSI\u7684\u5f8c\u671f\u5927\u8178\u764c\u75c5\u4eba\uff0c\u4f7f\u7528\u514d\u75ab\u6cbb\u7642\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\uff0c\u6bd4\u50b3\u7d71\u5316\u7642\u52a0\u6a19\u9776\u85e5\u66f4\u6709\u6548\u3002<\/p>\n\n\n\n

\uff08\u672c\u7db2\u767c\u8868\u7684\u4f5c\u54c1\u82e5\u63d0\u51fa\u6279\u8a55\uff0c\u65e8\u5728\u6307\u51fa\u76f8\u95dc\u5236\u5ea6\u3001\u653f\u7b56\u6216\u63aa\u65bd\u5b58\u5728\u932f\u8aa4\u6216\u7f3a\u9ede\uff0c\u76ee\u7684\u662f\u4fc3\u4f7f\u77ef\u6b63\u6216\u6d88\u9664\u9019\u4e9b\u932f\u8aa4\u6216\u7f3a\u9ede\uff0c\u5faa\u5408\u6cd5\u9014\u5f91\u4e88\u4ee5\u6539\u5584\uff0c\u7d55\u7121\u610f\u5716\u717d\u52d5\u4ed6\u4eba\u5c0d\u653f\u5e9c\u6216\u5176\u4ed6\u793e\u7fa4\u7522\u751f\u618e\u6068\u3001\u4e0d\u6eff\u6216\u6575\u610f\u3002\uff09<\/p>\n\n\n\n\n\n\n\n

\u6587\uff1a\u8523\u5b50\u6a11\uff08\u9999\u6e2f\u5927\u5b78\u81e8\u7240\u816b\u7624\u79d1\u81e8\u7240\u52a9\u7406\u6559\u6388\uff09<\/p>\n\n\n\n

\u7de8\u8f2f\uff1a\u6881\u5c0f\u73b2<\/p>\n\n\n\n

facebook @\u660e\u5831\u526f\u520a<\/p>\n\n\n\n

\u660e\u5831\u5065\u5eb7\u7db2\uff1awww.afterroberto.com<\/a><\/p>\n\n\n\n

\u96fb\u90f5\uff1afeature@mingpao.com<\/a><\/p>\n\n\n\n