{"id":31834,"date":"2021-04-02T13:00:15","date_gmt":"2021-04-02T05:00:15","guid":{"rendered":"\/\/www.afterroberto.com\/?p=31834"},"modified":"2021-04-01T20:03:10","modified_gmt":"2021-04-01T12:03:10","slug":"%e8%a1%80%e7%99%8c-%e5%bb%a3%e6%b3%9b%e6%87%89%e7%94%a8%e5%9f%ba%e5%9b%a0%e6%8a%80%e8%a1%93%e6%b2%bb%e7%99%82%e8%a1%80%e7%99%8c-%e9%86%ab%e8%a8%80%e6%9c%89%e7%90%86","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e8%a1%80%e7%99%8c-%e5%bb%a3%e6%b3%9b%e6%87%89%e7%94%a8%e5%9f%ba%e5%9b%a0%e6%8a%80%e8%a1%93%e6%b2%bb%e7%99%82%e8%a1%80%e7%99%8c-%e9%86%ab%e8%a8%80%e6%9c%89%e7%90%86\/","title":{"rendered":"\u3010\u8840\u764c\u3011\u5ee3\u6cdb\u61c9\u7528\u57fa\u56e0\u6280\u8853\u6cbb\u7642\u8840\u764c\uff08\u91ab\u8a00\u6709\u7406\uff09"},"content":{"rendered":"

\u3010\u660e\u5831\u5c08\u8a0a\u3011\u4e0d\u540c\u7684\u91ab\u7642\u9818\u57df\u6b63\u5ee3\u6cdb\u5229\u7528\u57fa\u56e0\u6280\u8853\u4f5c\u8a3a\u65b7\u53ca\u6cbb\u7642\u4e4b\u7528\uff0c\u65b0\u51a0\u75c5\u6bd2\u6e2c\u8a66\u662f\u597d\u4f8b\u5b50\uff1b\u764c\u75c7\u8a3a\u65b7\u53ca\u6cbb\u7642\u4ea6\u7d93\u5e38\u5229\u7528\u57fa\u56e0\u6280\u8853\uff0c\u5c24\u5176\u8840\u764c\u3002<\/p>\n

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\u6309\u57fa\u56e0\u8b8a\u5316\u5206\u985e \u5b9a\u6700\u4f73\u7642\u6cd5<\/strong><\/h2>\n

\u8840\u764c\u4e43\u9999\u6e2f\u5341\u5927\u764c\u75c7\u4e4b\u4e00\uff0c\u6bcf\u5e74\u6709\u6578\u4ee5\u5343\u8a08\u65b0\u78ba\u8a3a\u8005\uff0c\u5176\u4e2d\u5305\u62ec\u300c\u6025\u6027\u53ca\u6162\u6027\u767d\u8840\u75c5\u300d\uff08acute and chronic leukaemia\uff09\u3001\u300c\u6dcb\u5df4\u764c\u300d\uff08lymphoma\uff09\u53ca\u300c\u9aa8\u9ad3\u764c\u300d\uff08myeloma\uff09\u3002\u8fd1\u5e74\u91ab\u7642\u79d1\u6280\u6025\u901f\u767c\u5c55\uff0c\u8840\u764c\u60a3\u8005\u6cbb\u7652\u6a5f\u6703\u5927\u5927\u6539\u5584\u3002<\/p>\n

\"\" <\/picture>
\u8840\u764c\u662f\u672c\u6e2f\u5341\u5927\u764c\u75c7\u4e4b\u4e00\uff0c\u6bcf\u5e74\u6709\u6578\u4ee5\u5343\u8a08\u65b0\u78ba\u8a3a\u8005\u3002\uff08\u8cc7\u6599\u5716\u7247\uff09<\/figcaption><\/figure>\n

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\u75c5\u7406\u5c08\u5bb6\u5df2\u5ee3\u6cdb\u5229\u7528\u57fa\u56e0\u6e2c\u8a66\uff0c\u70ba\u8840\u764c\u60a3\u8005\u4f5c\u7cbe\u6e96\u8a3a\u65b7\uff1b\u6839\u64da\u764c\u7d30\u80de\u57fa\u56e0\u8b8a\u5316\uff0c\u70ba\u4e0d\u540c\u8840\u764c\u4f5c\u4ed4\u7d30\u5206\u985e\uff0c\u6709\u52a9\u6c7a\u5b9a\u6700\u4f73\u6cbb\u7642\u65b9\u6cd5\uff0c\u540c\u6642\u8a55\u4f30\u9810\u5f8c\u3002<\/p>\n

\u4ee5\u300c\u6025\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u300d\uff08acute myeloid leukaemia\uff09\u70ba\u4f8b\uff0c\u764c\u7d30\u80de\u542bPML-RARA\u878d\u5408\u57fa\u56e0\uff0c\u53ef\u78ba\u8a3a\u300c\u6025\u6027\u65e9\u5e7c\u7c92\u7d30\u80de\u767d\u8840\u75c5\u300d\uff08acute promyelocytic leukaemia\uff09\uff0c\u8655\u65b9\u300c\u5168\u53cd\u5f0f\u7dad\u7532\u9178\u300d\uff08all trans retinoic acid\uff09\u53ca\u300c\u4e09\u6c27\u5316\u4e8c\u7837\u300d\uff08arsenic trioxide\uff09\uff0c\u7642\u6548\u751a\u4f73\uff0c\u9810\u5f8c\u826f\u597d\u3002\u53e6\u5916\u5169\u7a2e\u878d\u5408\u57fa\u56e0RUNX1-RUNX1T1\u53caCBFB-MYH11\uff0c\u540c\u6a23\u6709\u8f03\u4f73\u9810\u5f8c\u3002\u76f8\u53cd\uff0c\u300c\u6025\u6027\u9ad3\u7d30\u80de\u767d\u8840\u75c5\u300d\u764c\u7d30\u80de\u542bFLT-3\u57fa\u56e0\u7a81\u8b8a\uff0c\u9810\u5f8c\u6703\u8f03\u5dee\uff0c\u8655\u65b9\u5316\u7642\u6642\u53ef\u52a0\u5165FTL-3\u6291\u5236\u5291\u5982Midostaurin\uff0c\u53ef\u52a0\u5f37\u7642\u6548\uff0c\u540c\u6642\u5efa\u8b70\u75c5\u60c5\u7de9\u89e3\u5f8c\u61c9\u76e1\u5feb\u5b89\u6392\u63a5\u53d7\u300c\u7570\u9ad4\u8840\u5e79\u7d30\u80de\u79fb\u690d\u300d\uff08allogeneic haematopoietic stem cell transplantation\uff09\uff0c\u53ef\u589e\u6cbb\u7652\u6a5f\u6703\u3002<\/p>\n

\u300c\u6025\u6027\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\u300d\uff08acute lymphoblastic leukaemia\uff09\u8f03\u591a\u5f71\u97ff\u5e74\u8f15\u4eba\uff0c\u90e8\u5206\u60a3\u8005\u764c\u7d30\u80de\u542bbcr-abl\u878d\u5408\u57fa\u56e0\uff0c\u9810\u5f8c\u8f03\u5dee\uff0c\u4f46\u8655\u65b9\u5316\u7642\u6642\u52a0\u5165\u6a19\u9776\u85e5\u7269tyrosine kinase inhibitor\uff0c\u53ef\u63d0\u9ad8\u7642\u6548\uff0c\u7de9\u89e3\u5f8c\u4ea6\u5efa\u8b70\u63a5\u53d7\u300c\u7570\u9ad4\u8840\u5e79\u7d30\u80de\u79fb\u690d\u300d\u3002<\/p>\n

\u300c\u5d4c\u5408\u6297\u539f\u53d7\u9ad4T\u7d30\u80de\u7642\u6cd5\u300d\uff08chimeric antigen receptor T cell therapy\uff0cCAR-T\uff09\u5c6c\u4e00\u7a2e\u300c\u7d30\u80de\u514d\u75ab\u7642\u6cd5\u300d \uff08cellular immunotherapy\uff09\uff0c\u53ef\u6709\u6548\u6cbb\u7642\u591a\u7a2e\u8840\u764c\uff0c\u5305\u62ec\u300c\u6025\u6027B\u6dcb\u5df4\u7d30\u80de\u767d\u8840\u75c5\u300d\u3001\u300c\u7030\u6f2b\u5927B\u7d30\u80de\u6dcb\u5df4\u764c\u300d\uff08diffuse large B cell lymphoma\uff09\u53ca\u300c\u5957\u7d30\u80de\u6dcb\u5df4\u764c\u300d\uff08mantle cell lymphoma\uff09\uff0c\u6548\u679c\u986f\u8457\u3002\u5148\u5f9e\u75c5\u8005\u8840\u6db2\u6536\u96c6\u300cT\u6dcb\u5df4\u7d30\u80de\u300d\uff08T-lymphocytes\uff09\uff0c\u7136\u5f8c\u5728\u7121\u83cc\u5be6\u9a57\u5ba4\u5167\u70baT\u7d30\u80de\u9032\u884c\u57fa\u56e0\u6539\u9020\u5de5\u7a0b\uff0c\u52a0\u5165\u300c\u5d4c\u5408\u6297\u539f\u53d7\u9ad4\u300d\uff08chimeric antigen receptor\uff09\uff0c\u7136\u5f8c\u57f9\u690d\u3002\u7d93\u904e\u6539\u9020\u5f8c\u7684T\u7d30\u80de\uff0c\u80fd\u5920\u78ba\u8a8d\u76ee\u6a19\u764c\u7d30\u80de\u4e0a\u7279\u5b9a\u6297\u539f\uff0c\u7cbe\u6e96\u6d88\u6ec5\u764c\u7d30\u80de\u3002<\/p>\n

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