{"id":27301,"date":"2020-07-06T12:59:39","date_gmt":"2020-07-06T04:59:39","guid":{"rendered":"\/\/www.afterroberto.com\/?p=27301"},"modified":"2023-10-05T14:09:57","modified_gmt":"2023-10-05T06:09:57","slug":"%e6%b2%bb%e6%9c%ab%e6%9c%9f%e5%a4%a7%e8%85%b8%e7%99%8c-%e6%96%b0%e4%b8%80%e7%b7%9a%e6%9b%99%e5%85%89-24%e5%80%8b%e6%9c%88%e7%84%a1%e6%83%a1%e5%8c%96%e5%ad%98%e6%b4%bb%e6%9c%9f","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e6%b2%bb%e6%9c%ab%e6%9c%9f%e5%a4%a7%e8%85%b8%e7%99%8c-%e6%96%b0%e4%b8%80%e7%b7%9a%e6%9b%99%e5%85%89-24%e5%80%8b%e6%9c%88%e7%84%a1%e6%83%a1%e5%8c%96%e5%ad%98%e6%b4%bb%e6%9c%9f\/","title":{"rendered":"\u6cbb\u672b\u671f\u5927\u8178\u764c \u65b0\u4e00\u7dda\u66d9\u5149 24\u500b\u6708\u7121\u60e1\u5316\u5b58\u6d3b\u671f \u5347\u81f348%"},"content":{"rendered":"<figure id=\"attachment_27303\" aria-describedby=\"caption-attachment-27303\" style=\"width: 800px\" class=\"wp-caption alignnone\"><picture><source 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class=\"wp-caption-text\">\uff08\u660e\u5831\u88fd\u5716\uff09<\/figcaption><\/figure>\n<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u4e00\u773e\u6cbb\u764c\u65b9\u6848\u4e2d\uff0c\u514d\u75ab\u6cbb\u7642\u4e0d\u76f4\u63a5\u653b\u64ca\u764c\u7d30\u80de\uff0c\u800c\u662f\u901a\u904e\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7d71\u4f86\u6d88\u6ec5\u816b\u7624\u3002\u7576\u4e2d\u5305\u62ec\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u3001\u904e\u7e7cT\u7d30\u80de\u7642\u6cd5\u3001\u764c\u75c7\u75ab\u82d7\uff0c\u9084\u6709\u525b\u7372FDA\u6279\u51fa\uff0c\u4e0d\u9650\u764c\u7a2e\u3001\u4f9d\u64da\u816b\u7624\u751f\u7269\u6a19\u8a18\u300c\u5fae\u885b\u661f\u4e0d\u7a69\u5b9a\u300d\uff08MSI\uff09\u800c\u7528\u7684\u85e5\u7269\uff0c\u90fd\u5c6c\u514d\u75ab\u6cbb\u7642\u3002\u6700\u65b0\u7814\u7a76\u986f\u793a\uff0c\u5408\u9069\u7684\u7b2c4\u671f\u7d50\u76f4\u8178\u764c\u60a3\u8005\u82e5\u904b\u7528\u65b0\u7642\u6cd5\uff0c24\u500b\u6708\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u63d0\u5347\u81f348%\uff0c\u66f4\u52dd\u5316\u7642\u60a3\u8005\u768419\uff05\u3002<\/p>\n<p>\u4e0d\u5c11\u764c\u75c7\u60a3\u8005\u90fd\u6703\u554f\uff1a\u6211\u9069\u5408\u514d\u75ab\u6cbb\u7642\u55ce\uff1f<br 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id=\"attachment_27305\" aria-describedby=\"caption-attachment-27305\" style=\"width: 284px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-27305\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc1495dc46acf89df96b11874075fb.jpg\" alt=\"\" width=\"284\" height=\"283\" title=\"\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc1495dc46acf89df96b11874075fb.jpg 284w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc1495dc46acf89df96b11874075fb-150x150.jpg 150w\" sizes=\"(max-width: 284px) 100vw, 284px\" \/><figcaption id=\"caption-attachment-27305\" class=\"wp-caption-text\">\u5433\u5049\u68e0\uff08\u53d7\u8a2a\u8005\u63d0\u4f9b\uff09<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<h2>\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff08immune checkpoint inhibitor\uff09<\/h2>\n<p>PD-1\u662fT\u7d30\u80de\uff08\u514d\u75ab\u7d30\u80de\uff09\u4e0a\u7684\u6aa2\u67e5\u9ede\u86cb\u767d\uff0c\u7576\u5b83\u9644\u5728PD-L1\uff08\u7d30\u80de\u4e0a\u7684\u86cb\u767d\u8cea\uff09\u6642\uff0cT\u7d30\u80de\u4fbf\u6703\u505c\u6b62\u653b\u64ca\u3002\u9673\u7a4e\u6a02\u6307\uff0c\u4e00\u4e9b\u764c\u7d30\u80de\u542b\u6709\u5927\u91cfPD-L1\uff0c\u7576PD-1\u8207PD-L1\u7d50\u5408\u6642\uff0c\u80fd\u963b\u7919T\u7d30\u80de\u8fa8\u8a8d\u51fa\u764c\u7d30\u80de\uff0c\u5f9e\u800c\u8eb2\u904e\u514d\u75ab\u7cfb\u7d71\u653b\u64ca\u3002\u9776\u9edePD-1\u6216PD-L1\u7684\u55ae\u682a\u6297\u9ad4\u53ef\u4ee5\u963b\u65b7\u9019\u7a2e\u7d50\u5408\uff0c\u4e26\u589e\u5f37\u91dd\u5c0d\u764c\u7d30\u80de\u7684\u514d\u75ab\u53cd\u61c9\u3002<\/p>\n<figure id=\"attachment_27306\" aria-describedby=\"caption-attachment-27306\" style=\"width: 284px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" class=\"size-full wp-image-27306\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc0e410e81329195a8e0e4a79d6ecf.jpg\" alt=\"\" width=\"284\" height=\"284\" title=\"\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc0e410e81329195a8e0e4a79d6ecf.jpg 284w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc0e410e81329195a8e0e4a79d6ecf-150x150.jpg 150w\" sizes=\"(max-width: 284px) 100vw, 284px\" \/><figcaption id=\"caption-attachment-27306\" class=\"wp-caption-text\">\u9673\u7a4e\u6a02\uff08\u8cc7\u6599\u5716\u7247\uff09<\/figcaption><\/figure>\n<h2>\u5148\u6aa2\u67e5\u76f8\u95dc\u764c\u75c7\u56e0\u5b50<\/h2>\n<p>\u81e8\u7240\u5e38\u7528\u7684\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291\uff0c\u5982pembrolizumab\u3001durvalumab\u3001nivolumab\u7b49\u85e5\u7269\uff0c\u91dd\u5c0dPD1\/PD-L1\u9776\u9ede\uff0c\u8b93\u514d\u75ab\u7cfb\u7d71\u6d88\u6ec5\u6216\u6291\u58d3\u764c\u7d30\u80de\u3002\u5b83\u5011\u9069\u7528\u65bc\u591a\u7a2e\u764c\u75c7\uff0c\u5982\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u3001\u8178\u764c\u3001\u80c3\u764c\u3001\u98df\u9053\u764c\u3001\u5b50\u5bae\u5167\u819c\u764c\u4e36\u4e09\u9670\u6027\u4e73\u764c\u7b49\u3002\u60a3\u8005\u9700\u5148\u6aa2\u67e5\u764c\u75c7\u76f8\u95dc\u56e0\u5b50\uff0c\u5982PD-L1\uff0c\u624d\u6c7a\u5b9a\u662f\u5426\u9069\u5408\u7528\u85e5\u3002\u4e00\u822c\u800c\u8a00\uff0c\u9700\u6bcf\u96942\u81f33\u661f\u671f\u6ce8\u5c04\u85e5\u7269\uff0c\u6bcf\u91dd\u8cbb\u7528\u7d042\u842c\u81f33\u842c\u5143\u3002\u96d6\u7136\u526f\u4f5c\u7528\u8f03\u5c0f\uff0c\u4f46\u4ecd\u6709\u5c11\u65bc5%\u60a3\u8005\u6709\u8178\u708e\u3001\u76ae\u819a\u708e\uff0c\u4ea6\u66fe\u6709\u60a3\u8005\u773c\u775b\u795e\u7d93\u7dda\u51fa\u73fe\u554f\u984c\u81f4\u76f2\u3002<\/p>\n<h2>\u904e\u7e7c\u6027T\u7d30\u80de\u6cbb\u7642\uff08adoptive T-cell therapy\uff09<\/h2>\n<p>\u539f\u7406\u662f\u5c07T\u7d30\u80de\u7684\u53d7\u9ad4\u7528\u57fa\u56e0\u6539\u9020\u4fee\u6539\uff0c\u4ee4T\u7d30\u80de\u5177\u76e3\u5bdf\u816b\u7624\u6297\u539f\u7684\u80fd\u529b\u3002\u5d4c\u5408\u6297\u539f\u53d7\u9ad4T\u7d30\u80de\uff08CAR-T\uff09\u7642\u6cd5\u662f\u904e\u7e7c\u6027T\u7d30\u80de\u6cbb\u7642\u7684\u4e00\u7a2e\uff0c\u53ef\u7528\u65bc\u8840\u764c\u3001\u6dcb\u5df4\u816b\u7624\u3002\u5433\u5049\u68e0\u8868\u793a\uff0c\u64da\u4e86\u89e3\uff0c\u76ee\u524d\u672c\u6e2f\u672a\u6b63\u5f0f\u5f15\u5165CAR-T\u7642\u6cd5\u5728\u81e8\u7240\u4f7f\u7528\u3002<\/p>\n<h2>\u764c\u75c7\u75ab\u82d7<\/h2>\n<p>\u75ab\u82d7\u4e3b\u8981\u4f5c\u7528\u662f\u523a\u6fc0T\u7d30\u80de\uff0c\u8fa8\u8b58\u5230\u5e36\u6709\u816b\u7624\u6297\u539f\u7684\u764c\u7d30\u80de\u3002\u505a\u6cd5\u662f\u62bd\u53d6\u75c5\u4eba\u8840\u6f3f\uff0c\u5206\u96e2\u51fa\u767d\u8840\u7403\u5f8c\u52a0\u5165PAP\u6297\u539f\uff0c\u5728\u5be6\u9a57\u5ba4\u57f9\u690d\u4e00\u6bb5\u6642\u9593\u5f8c\u518d\u6ce8\u5c04\u5165\u60a3\u8005\u8eab\u9ad4\u3002\u5433\u5049\u68e0\u89e3\u91cb\uff0c\u7576\u81ea\u8eab\u514d\u75ab\u7cfb\u7d71\u898b\u5230PAP\u6297\u539f\uff0c\u6b63\u5e38\u7d30\u80de\u4fbf\u6703\u767c\u63ee\u4f5c\u7528\uff0c\u5f9e\u800c\u7834\u58de\u764c\u7d30\u80de\u3002\u66ab\u6642\u53ea\u6709\u4e00\u6b3e\u91dd\u5c0d\u524d\u5217\u817a\u764c\u7684\u75ab\u82d7sipuleucel-T\uff0c\u4f46\u56e0\u70ba\u88fd\u4f5c\u7a0b\u5e8f\u7e41\u8907\uff0c\u9999\u6e2f\u4e26\u4e0d\u666e\u904d\u4f7f\u7528\u3002<\/p>\n<h2>\u5fae\u885b\u661f\u4e0d\u7a69\u5b9a 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class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-27304\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc1b03b07ab35e9fa2089909bc3e22.jpg\" alt=\"\" width=\"800\" height=\"600\" title=\"\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc1b03b07ab35e9fa2089909bc3e22.jpg 800w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc1b03b07ab35e9fa2089909bc3e22-300x225.jpg 300w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc1b03b07ab35e9fa2089909bc3e22-150x113.jpg 150w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc1b03b07ab35e9fa2089909bc3e22-768x576.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-27304\" class=\"wp-caption-text\">\u5433\u96f2\u82f1\uff08\u674e\u7956\u6021\u651d\uff09<\/figcaption><\/figure>\n<p>MSI-H\u5728\u67d0\u5e7e\u985e\u764c\u75c7\u7279\u5225\u5e38\u898b\u3002\u6839\u64da2017\u5e74JCO precision oncology\u7684\u6587\u737b\uff0c\u8abf\u67e539\u7a2e\u764c\u75c7\uff0c\u5176\u4e2d27\u7a2e\u6aa2\u6e2c\u5230MSI\uff0c\u7576\u4e2d\u99965\u7a2eMSI-H\u764c\u75c7\u4f9d\u6b21\u70ba\u5b50\u5bae\u764c\uff0831.4%\uff09\u3001\u7d50\u8178\u764c\uff0819.7%\uff09\u3001\u80c3\u764c\uff0819.1%\uff09\u3001\u76f4\u8178\u764c\uff085.7%\uff09\u3001\u814e\u4e0a\u817a\u76ae\u8cea\u764c\uff084.4%\uff09\u3002<\/p>\n<h2>\u57fa\u56e0\u8f49\u8b8a\u6108\u591a \u514d\u75ab\u7cfb\u7d71\u6108\u6613\u5bdf\u89ba<\/h2>\n<p>\u5433\u5049\u68e0\u88dc\u5145\uff0c\u816b\u7624\u57fa\u672c\u4e0a\u662f\u57fa\u56e0\u8f49\u8b8a\u4e0b\u7684\u58de\u7d30\u80de\uff0c\u800c\u57fa\u56e0\u8f49\u8b8a\u6709\u8a31\u591a\u4e0d\u540c\u7684\u5f62\u5f0f\uff0c\u5982\u679c\u57fa\u56e0\u8f49\u8b8a\u6108\u591a\uff0c\u88ab\u514d\u75ab\u7cfb\u7d71\u76e3\u5bdf\u5230\u7684\u6a5f\u6703\u5c31\u6108\u9ad8\uff0cMSI\u662f\u5176\u4e2d\u4e00\u500b\u57fa\u56e0\u8f49\u8b8a\u53ef\u88abT\u7d30\u80de\u8fa8\u5225\u7684\u751f\u7269\u6a19\u8a18\u3002\u816b\u7624\u7a81\u8b8a\u8ca0\u8377\uff08tumor mutational burden\uff0cTMB\uff09\u662f\u53e6\u4e00\u514d\u75ab\u6cbb\u7642\u7684\u751f\u7269\u6a19\u8a18\uff0c\u5177\u6709\u9ad8\u5ea6\u816b\u7624\u7a81\u8b8a\u8ca0\u8377\u91cf\u7684\u60a3\u8005\uff0c\u5c0d\u514d\u75ab\u6cbb\u7642\u7684\u53cd\u61c9\u66f4\u4f73\u3002<\/p>\n<p>\u904e\u5f80\u7528\u85e5\u8981\u5c0d\u6e96\u816b\u7624\u539f\u767c\u90e8\u4f4d\uff0c\u73fe\u5728\u662f\u57fa\u65bc\u816b\u7624\u751f\u7269\u6a19\u8a18\u5c0d\u75c7\u4e0b\u85e5\uff0c\u5433\u96f2\u82f1\u8a8d\u70ba\u9019\u662f\u4e0d\u5b9a\u816b\u7624\u985e\u578b\uff08tumor-agnostic indication\uff09\u7684\u6cbb\u7642\u65b0\u9078\u64c7\u3002<\/p>\n<hr \/>\n<h2>\u77e5\u591a\u5572\uff1a\u91ab\u751f\uff1a\u975e\u6240\u6709\u764c\u60a3\u9808\u9a57MSI<\/h2>\n<figure id=\"attachment_27308\" aria-describedby=\"caption-attachment-27308\" style=\"width: 401px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-27308\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc3b53b6fa9412d17a66160292a44b.jpg\" alt=\"\" width=\"401\" height=\"282\" title=\"\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc3b53b6fa9412d17a66160292a44b.jpg 401w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc3b53b6fa9412d17a66160292a44b-300x211.jpg 300w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc3b53b6fa9412d17a66160292a44b-150x105.jpg 150w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc3b53b6fa9412d17a66160292a44b-130x90.jpg 130w\" sizes=\"(max-width: 401px) 100vw, 401px\" \/><figcaption id=\"caption-attachment-27308\" class=\"wp-caption-text\">\u526f\u4f5c\u7528\u2014\u2014ASCO\u6700\u65b0\u516c\u5e03\u7684\u7814\u7a76\u986f\u793a\uff0c\u7b2c4\u671f\u7d50\u76f4\u8178\u764c\u60a3\u8005\u7684pembrolizumab\u7d44\u548c\u5316\u7642\u7d44\uff0c\u5747\u66fe\u51fa\u73fe\u8179\u7009\u3001\u75b2\u52de\u3001\u4f5c\u5614\u4f5c\u60b6\u548c\u812b\u9aee\u7b49\u526f\u4f5c\u7528\u3002\uff08ipopba@iStockphoto\uff09<\/figcaption><\/figure>\n<p>\u525b\u65bc6\u6708\u8209\u884c\u7684\u7f8e\u570b\u81e8\u7240\u816b\u7624\u5b78\u6703\uff08ASCO\uff09\uff0c\u516c\u5e03\u4e00\u9805\u6709\u95dcMSI-H\u7d50\u76f4\u8178\u764c\u7814\u7a76\uff0c\u6bd4\u8f03\u5316\u7642\u53ca\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291pembrolizumab\u7684\u7642\u6548\u3002\u7814\u7a76\u62db\u52df\u7d04300\u540dMSI-H\u7b2c4\u671f\u7d50\u76f4\u8178\u764c\u3001\u672a\u63a5\u53d7\u4efb\u4f55\u6cbb\u7642\u65b9\u6848\u7684\u60a3\u8005\u53c3\u8207\u3002\u7d50\u679c\u986f\u793a\uff0cpembrolizumab\u7d44\u5225\u768424\u500b\u6708\u7121\u60e1\u5316\u5b58\u6d3b\u671f\uff08PFS\uff09\u70ba48%\uff0c\u5316\u7642\u7d44\u5225\u5247\u70ba19\uff05\u3002\u526f\u4f5c\u7528\u65b9\u9762\uff0cpembrolizumab\u7d44\u548c\u5316\u7642\u7d44\u5206\u5225\u670922%\u548c66%\u51fa\u73fe\u7b2c3\u7d1a\u6216\u4ee5\u4e0a\u4e0d\u826f\u53cd\u61c9\uff08\u5c6c\u56b4\u91cd\u526f\u4f5c\u7528\uff09\uff0c\u4f8b\u5982\u8179\u7009\u3001\u75b2\u52de\u3001\u4f5c\u5614\u4f5c\u60b6\u3001\u812b\u9aee\u7b49\u3002<\/p>\n<p>\u91dd\u5c0dMSI-H\u5927\u8178\u764c\uff0c\u7f8e\u570b\u98df\u54c1\u53ca\u85e5\u7269\u7ba1\u7406\u5c40\uff08FDA\uff09\u65bc2017\u5e74\u6279\u51c6\u4f7f\u7528\u53e6\u4e00\u6b3e\u514d\u75ab\u6aa2\u67e5\u9ede\u6291\u5236\u5291nivolumab\u4f5c\u6cbb\u7642\u3002\u800c\u57fa\u65bc\u6700\u65b0\u81e8\u7240\u7814\u7a76\u6578\u64da\uff0cFDA\u4ea6\u6279\u51c6pembrolizumab\u7528\u65bcMSI-H\u53ca\u7121\u6cd5\u5207\u9664\u6216\u8f49\u79fb\u6027\u5927\u8178\u764c\uff0c\u4f5c\u70ba\u4e00\u7dda\u6cbb\u7642\u3002<\/p>\n<p>\u5927\u8178\u764c\u662f\u9999\u6e2f\u764c\u75c7\u4e4b\u9996\uff0c2017\u5e74\u67095635\u5b97\u65b0\u75c7\u3002\u514d\u75ab\u6cbb\u7642\u662f\u5426\u512a\u65bc\u5176\u4ed6\u764c\u75c7\u6cbb\u7642\uff1f\u81e8\u7240\u816b\u7624\u79d1\u5c08\u79d1\u91ab\u751f\u5433\u96f2\u82f1\u5f37\u8abf\uff0c\u514d\u75ab\u6cbb\u7642\u53ea\u662f\u764c\u75c7\u6cbb\u7642\u7684\u5176\u4e2d\u4e00\u7a2e\uff0c\u75c5\u4eba\u61c9\u5148\u63a5\u53d7\u57fa\u56e0\u6aa2\u6e2c\uff0c\u624d\u6c7a\u5b9a\u6cbb\u7642\u65b9\u6848\u3002\u4ee5\u7b2c4\u671f\u7d50\u76f4\u8178\u764c\u70ba\u4f8b\uff0c\u91dd\u5c0d\u4e0d\u540c\u751f\u7269\u6a19\u8a18\uff0c\u6709\u4e0d\u540c\u85e5\u7269\u9078\u64c7\uff08\u898b\u5716\u4e00\uff09\uff1a<\/p>\n<figure id=\"attachment_27307\" aria-describedby=\"caption-attachment-27307\" style=\"width: 420px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-27307\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc41d3c8a1d17487aee4582cb9860b.jpg\" alt=\"\" width=\"420\" height=\"283\" title=\"\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc41d3c8a1d17487aee4582cb9860b.jpg 420w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc41d3c8a1d17487aee4582cb9860b-300x202.jpg 300w, \/\/www.afterroberto.com\/wp-content\/uploads\/2020\/07\/42fc41d3c8a1d17487aee4582cb9860b-150x101.jpg 150w\" sizes=\"(max-width: 420px) 100vw, 420px\" \/><figcaption id=\"caption-attachment-27307\" class=\"wp-caption-text\">\uff08\u660e\u5831\u88fd\u5716\uff09<\/figcaption><\/figure>\n<h2>\u5927\u8178\u764c\u5efa\u8b70\u505aMSI\u6aa2\u6e2c<\/h2>\n<p>\u6839\u64da\u7f8e\u570b\u570b\u5bb6\u7d9c\u5408\u764c\u75c7\u7db2\u7d61\uff08National Comprehensive Cancer Network\uff0cNCCN\uff09\u5efa\u8b70\uff0c\u8178\u764c\u60a3\u8005\u61c9\u63a5\u53d7MSI\u6aa2\u6e2c\u3002\u5433\u96f2\u82f1\u8868\u793a\uff0c\u4e0d\u8ad6\u662f\u65e9\u671f\u6216\u64f4\u6563\u6027\u764c\u75c7\u60a3\u8005\uff0c\u300c\u662f\u5426\u5177\u6709MSI-H\u300d\u662f\u91ab\u751f\u9078\u64c7\u6cbb\u7642\u65b9\u6848\u6642\u6240\u8003\u616e\u7684\u5176\u4e2d\u4e00\u500b\u56e0\u7d20\u3002\u4f46\u5c0d\u65bc\u4e0d\u540c\u764c\u75c7\uff0c\u5404\u7a2e\u751f\u7269\u6a19\u8a18\u7684\u91cd\u8981\u7a0b\u5ea6\u90fd\u4e0d\u540c\uff0c\u56e0\u6b64\u4e26\u975e\u6240\u6709\u764c\u75c7\u75c5\u4eba\u90fd\u9700\u8981\u505a\u76f8\u95dc\u6aa2\u9a57\u3002<\/p>\n<h2>MSI\u6aa2\u6e2c\u65b9\u6cd5<\/h2>\n<h2>\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u6cd5\uff08immunohistochemical staining\uff0cIHC\uff09<\/h2>\n<p>\u539f\u7406\uff1a\u6aa2\u6e2c\u932f\u914d\u4fee\u5fa9\u57fa\u56e0\u7684\u86cb\u767d<\/p>\n<p>\u9700\u6642\uff1a5\u81f37\u5929<\/p>\n<p>\u8cbb\u7528\uff1a\u7d045000\u30016000\u5143<\/p>\n<h2>\u805a\u5408\u9176\u93c8\u53cd\u61c9\uff08polymerase chain reaction\uff0cPCR\uff09<\/h2>\n<p>\u539f\u7406\uff1a\u91dd\u5c0dMSI\u4e0a\u7684\u6a19\u8a18\u5206\u6790<\/p>\n<p>\u9700\u6642\uff1a5\u81f37\u5929<\/p>\n<p>\u8cbb\u7528\uff1a\u7d045000\u30016000\u5143<\/p>\n<h2>\u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff08next generation sequencing\uff0cNGS\uff09<\/h2>\n<p>\u539f\u7406\uff1a\u6aa2\u9a57\u4e00\u7c43\u5b50\u57fa\u56e0\uff0c\u5305\u62ecMSI\u57fa\u56e0<\/p>\n<p>\u9700\u6642\uff1a4\u661f\u671f<\/p>\n<p>\u8cbb\u7528\uff1a\u7d042\u81f34\u842c\u591a\u5143<\/p>\n<p>&nbsp;<\/p>\n<p>\u6587\uff1a\u674e\u7956\u6021<\/p>\n<p>\u7d71\u7c4c\uff1a\u912d\u5bf6\u83ef<\/p>\n<p>\u7de8\u8f2f\uff1a\u738b\u7fe0\u9e97<\/p>\n<p>\u96fb\u90f5\uff1a<a href=\"mailto:feature@mingpao.com\">feature@mingpao.com<\/a><\/p>\n<section class=\"widget_featured_posts\" style=\"margin-top: 50px;\">\n<h3 class=\"widget-title\" style=\"font-size: 23px; color: #188073;\">\u5c08\u984c\u7cfb\u5217\u6587\u7ae0<\/h3>\n<\/section>\n<ul class=\"lcp_catlist\" id=\"lcp_instance_0\"><li><a href=\"\/\/www.afterroberto.com\/%e6%9c%ac%e6%b8%af%e5%8d%81%e5%a4%a7%e7%99%8c%e7%97%87-%e4%b9%b3%e7%99%8c%e6%96%b0%e7%97%87%e8%b6%85%e8%b6%8a%e5%a4%a7%e8%85%b8%e7%99%8c%e4%bd%8d%e5%88%97%e7%ac%ac%e4%ba%8c-%e8%82%ba%e7%99%8c%e7%ba%8c\/\">\u3010\u672c\u6e2f\u5341\u5927\u764c\u75c7\u3011\u4e73\u764c\u65b0\u75c7\u8d85\u8d8a\u5927\u8178\u764c\u4f4d\u5217\u7b2c\u4e8c \u80ba\u764c\u7e8c\u5c45\u9996<\/a><\/li><li><a href=\"\/\/www.afterroberto.com\/%e4%b8%8d%e8%89%af%e9%a3%b2%e9%a3%9f%e7%94%9f%e6%b4%bb%e7%bf%92%e6%85%a3-%e5%a2%9e%e6%82%a3%e7%99%8c%e7%97%87%e9%a2%a8%e9%9a%aa\/\">\uff17\u500b\u4e0d\u826f\u98f2\u98df\u751f\u6d3b\u7fd2\u6163 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