{"id":25490,"date":"2020-03-23T11:22:01","date_gmt":"2020-03-23T03:22:01","guid":{"rendered":"\/\/www.afterroberto.com\/?p=25490"},"modified":"2023-10-05T14:11:09","modified_gmt":"2023-10-05T06:11:09","slug":"%e9%86%ab%e8%a8%80%e6%9c%89%e7%90%86%ef%bc%9a%e6%b7%8b%e5%b7%b4%e7%b5%90%e8%84%b9%e5%a4%a7-%e5%b0%8f%e5%bf%83tafro%e7%b6%9c%e5%90%88%e7%97%87","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e9%86%ab%e8%a8%80%e6%9c%89%e7%90%86%ef%bc%9a%e6%b7%8b%e5%b7%b4%e7%b5%90%e8%84%b9%e5%a4%a7-%e5%b0%8f%e5%bf%83tafro%e7%b6%9c%e5%90%88%e7%97%87\/","title":{"rendered":"\u91ab\u8a00\u6709\u7406\uff1a\u6dcb\u5df4\u7d50\u8139\u5927 \u5c0f\u5fc3TAFRO\u7d9c\u5408\u75c7"},"content":{"rendered":"
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\u3010\u660e\u5831\u5c08\u8a0a\u301150\u6b72\u7684\u738b\u5148\u751f\u5728\u5c0f\u5b78\u6559\u66f8\uff0c\u65e9\u524d\u767c\u73fe\u81ea\u5df1\u5168\u8eab\u591a\u8655\u6dcb\u5df4\u7d50\u8139\u5927\uff0c\u5305\u62ec\u9838\u90e8\u5169\u908a\u3001\u814b\u4e0b\u53ca\u8179\u80a1\u6e9d\u4f4d\u7f6e\uff0c\u5927\u5c0f\u7d041\u81f32\u5398\u7c73\u3002\u738b\u5148\u751f\u516c\u79c1\u5169\u5fd9\uff0c\u672a\u6709\u5c0f\u5fc3\u8655\u7406\u75c5\u60c5\uff0c\u6dcb\u5df4\u7d50\u5927\u5c0f\u4ea6\u4e00\u76f4\u6c92\u6709\u592a\u5927\u8b8a\u5316\u3002<\/p>\n

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\u4f46\u8fd1\u65e5\u738b\u5148\u751f\u51fa\u73fe\u4f4e\u71d2\u73fe\u8c61\uff0c\u7d0438\u2103\uff1b\u5168\u8eab\u6c34\u816b\uff0c\u773c\u767d\u5fae\u9ec3\uff1b\u5c0f\u4fbf\u5448\u6df1\u8336\u8272\uff0c\u4e26\u4e14\u5c3f\u91cf\u6e1b\u5c11\u3002\u9a57\u8840\u6aa2\u67e5\u986f\u793a\uff0c\u738b\u5148\u751f\u6709\u56b4\u91cd\u8ca7\u8840\uff0c\u4e26\u4e14\u8840\u5c0f\u677f\u6578\u91cf\u5927\u5e45\u4e0b\u964d\uff1b\u814e\u81df\u53ca\u809d\u81df\u7684\u529f\u80fd\u4ea6\u6709\u8870\u7aed\u8ff9\u8c61\uff0c\u300c\u808c\u9150\u300d\uff08Serum creatinine\uff09\u53ca\u300c\u81bd\u7d05\u7d20\u300d\uff08Serum bilirubin\uff09\u6c34\u5e73\u5927\u5e45\u4e0a\u5347\u3002<\/p>\n

\u300c\u6dcb\u5df4\u7d50\u6d3b\u7d44\u7e54\u6aa2\u67e5\u300d\uff08Lymph node biopsy\uff09\u986f\u793a\u738b\u5148\u751f\u60a3\u6709\u300c\u5361\u65af\u723e\u66fc\u75c5\u300d\uff08Castleman disease\uff09\uff0c\u5c6c\u514d\u75ab\u7cfb\u7d71\u6bdb\u75c5\uff0c\u5168\u8eab\u51fa\u73fe\u767c\u708e\u73fe\u8c61\uff1b\u300c\u9aa8\u9ad3\u6d3b\u7d44\u7e54\u6aa2\u67e5\u300d\uff08Bone marrow biopsy\uff09\u986f\u793a\u9aa8\u9ad3\u7e96\u7dad\u5316\uff08Myelofibrosis\uff09\u3002<\/p>\n

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\u8840\u5c0f\u677f\u4e0b\u964d \u591a\u5668\u5b98\u529f\u80fd\u8870\u7aed<\/h2>\n

\u90e8\u5206\u300c\u5361\u65af\u723e\u66fc\u75c5\u300d\u500b\u6848\u8207\u300c\u4eba\u985e\u76b0\u75b9\u516b\u578b\u75c5\u6bd2\u300d\uff08Human herpes virus 8\uff09\u611f\u67d3\u6709\u5bc6\u5207\u95dc\u4fc2\uff0c\u738b\u5148\u751f\u5c0d\u75c5\u6bd2\u6e2c\u8a66\u5448\u9670\u6027\u53cd\u61c9\u3002\u90e8\u5206\u5361\u65af\u723e\u66fc\u75c5\u500b\u6848\u5206\u5225\u8207\u7f55\u898b\u7684\u300cPOEMS\u7d9c\u5408\u75c7\u300d\u53ca\u300cTAFRO\u7d9c\u5408\u75c7\u300d\u6709\u95dc\uff0c\u6bcf\u4e00\u500b\u82f1\u6587\u5b57\u6bcd\u4ee3\u8868\u4e00\u500b\u7279\u6b8a\u75c5\u5fb5\u3002POEMS\u662f\u6307\u591a\u767c\u6027\u795e\u7d93\u7dda\u51fa\u73fe\u75c5\u8b8a\uff08Polyneuropathy\uff09\u3001\u809d\u813e\u53ca\u6dcb\u5df4\u7d50\u816b\u5927\uff08Organomegaly\uff09\u3001\u5167\u5206\u6ccc\u5931\u8abf\uff08Endocrinopathy\uff09\u3001\u6f3f\u7d30\u80de\u55ae\u514b\u9686\u589e\u751f\uff08Monoclonal plasma cell proliferation\uff09\u3001\u819a\u8272\u8b8a\u9ed1\u53ca\u591a\u6bdb\uff08Skin changes\uff09\uff1bTAFRO\u7d9c\u5408\u75c7\u7684\u75c5\u5fb5\u5247\u5305\u62ec\uff1a\u8840\u5c0f\u677f\u6578\u91cf\u6e1b\u5c11\uff08Thrombocytopenia\uff09\u3001\u5168\u8eab\u6c34\u816b\uff08Anasarca\uff09\u3001\u9aa8\u9ad3\u7e96\u7dad\u5316\uff08Marrow Reticulin Fibrosis\uff09\u3001\u814e\u529f\u80fd\u8870\u7aed\uff08Renal dysfunction\uff09\u3001\u809d\u813e\u8207\u6dcb\u5df4\u7d50\u816b\u5927\uff08Organomegaly\uff09\uff0c\u5176\u4ed6\u9084\u6709\u8ca7\u8840\uff08Anaemia\uff09\u53ca\u767c\u71b1\uff08Fever\uff09 \u3002<\/p>\n

\u6839\u64da\u738b\u5148\u751f\u7684\u75c5\u5fb5\uff0c\u53ef\u78ba\u8a3a\u60a3\u6709\u300cTAFRO\u7d9c\u5408\u75c7\u300d\uff0c\u4ed6\u7684\u8eab\u9ad4\u591a\u500b\u5668\u5b98\u529f\u80fd\u51fa\u73fe\u8870\u7aed\u73fe\u8c61\uff0c\u5c6c\u9ad8\u5371\u60c5\u51b5\uff1b\u91ab\u751f\u5148\u5f8c\u8655\u65b9\u985e\u56fa\u9187\u6fc0\u7d20\uff08Steroids\uff09\u3001IL-6\u53d7\u9ad4\u55ae\u6297\uff08Anti-Interleukin-6 receptor monoclonal antibody\uff0cTocilizumab\uff09\u53ca\u300cB\u7d30\u80de\u55ae\u6297\u300d\uff08Anti-B cell monoclonal antibody\uff09\u300c\u5229\u59a5\u6614\u300d\uff08Rituximab\uff09\uff0c\u9084\u6709\u6297T\u7d30\u80de\u85e5\u7269\u300c\u74b0\u5b62\u7d20\u300d\uff08Cyclosporine\uff09\u3002\u738b\u5148\u751f\u7684\u75c5\u60c5\u521d\u6b65\u53d7\u63a7\uff0c\u4f46\u4ecd\u8981\u5c0f\u5fc3\u75c5\u60c5\u53cd\u8986\u3002<\/p>\n

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