{"id":21000,"date":"2019-08-15T18:15:30","date_gmt":"2019-08-15T10:15:30","guid":{"rendered":"\/\/www.afterroberto.com\/?p=21000"},"modified":"2020-01-07T19:38:16","modified_gmt":"2020-01-07T11:38:16","slug":"%e6%89%8b%e8%a1%93%e5%8f%8a%e6%96%b0%e8%97%a5%e8%bf%bd%e6%93%8a%e8%82%9d%e7%99%8c-%e5%a2%9e%e7%99%82%e6%95%88%e5%8f%8a%e5%ad%98%e6%b4%bb%e7%8e%87","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e6%89%8b%e8%a1%93%e5%8f%8a%e6%96%b0%e8%97%a5%e8%bf%bd%e6%93%8a%e8%82%9d%e7%99%8c-%e5%a2%9e%e7%99%82%e6%95%88%e5%8f%8a%e5%ad%98%e6%b4%bb%e7%8e%87\/","title":{"rendered":"\u624b\u8853\u53ca\u65b0\u85e5\u8ffd\u64ca\u809d\u764c \u589e\u7642\u6548\u53ca\u5b58\u6d3b\u7387"},"content":{"rendered":"

\u809d\u764c\u662f\u672c\u6e2f\u7b2c\u4e09\u5927\u764c\u75c7\u6bba\u624b\uff0c2016\u5e74\u65b0\u589e\u500b\u6848\u7d041,800\u5b97\uff0c\u52a0\u4e0a\u903e\u516b\u6210\u809d\u764c\u8207\u4e59\u578b\u809d\u708e\u6709\u95dc\uff0c\u6545\u4e0d\u80fd\u6389\u4ee5\u8f15\u5fc3\u3002\u809d\u764c\u4ee5\u7537\u6027\u53ca\u4e2d\u5e74\u4ee5\u4e0a\u60a3\u8005\u4f54\u5927\u591a\u6578\uff0c\u60a3\u8005\u4e00\u822c\u5728\u521d\u671f\u6c92\u6709\u660e\u986f\u75c5\u5fb5\uff0c\u4f46\u7576\u51fa\u73fe\u4e0a\u8179\u75db\u3001\u8336\u8272\u5c0f\u4fbf\u6216\u9ec3\u75b8\uff0c\u5df2\u53ef\u80fd\u662f\u5f8c\u671f\u809d\u764c\u3002\u96a8\u8457\u8fd1\u5e74\u91ab\u5b78\u767c\u5c55\uff0c\u4e0d\u540c\u671f\u6578\u7684\u809d\u764c\u5df2\u6709\u76f8\u61c9\u6cbb\u7642\u624b\u6bb5\uff0c\u6709\u52a9\u589e\u52a0\u5b58\u6d3b\u7387\u3002\u990a\u548c\u91ab\u9662<\/a>\u53ca\u300a\u660e\u5831\u300b\u5065\u5eb7\u7db2\u65e9\u524d\u5047\u4e2d\u592e\u5716\u66f8\u9928\u8209\u8fa6\u300c\u809d\u764c\u8a3a\u7642\u65b0\u8da8\u52e2\u300d\u8b1b\u5ea7\uff0c\u8b93\u53c3\u52a0\u8005\u4e86\u89e3\u6700\u65b0\u7684\u8a3a\u65b7\u53ca\u6cbb\u7642\u65b9\u6cd5\uff0c\u70ba\u75c5\u8005\u53ca\u5bb6\u4eba\u5e36\u4f86\u65b0\u5e0c\u671b\u3002<\/p>\n

 <\/p>\n

\"\u990a\u548c\u91ab\u9662,\u809d\u764c,\u8b1b\u5ea7\"
\u8fd1\u5e74\u4e0d\u4e4f\u65b0\u7684\u624b\u8853\u5100\u5668\u53ca\u85e5\u7269\u6709\u6548\u6cbb\u7642\u4e0d\u540c\u671f\u6578\u7684\u809d\u764c\uff0c\u9673\u8a69\u6b63\u91ab\u751f\uff08\u53f3\uff09\u53ca\u6881\u60e0\u68e0\u91ab\u751f\u9f13\u52f5\u60a3\u8005\u7a4d\u6975\u9762\u5c0d\u75c5\u60c5\u3002<\/figcaption><\/figure>\n

 <\/p>\n

\u809d\u81df\u5177\u6709\u6d88\u5316\u3001\u5206\u6ccc\u81bd\u6c41\u3001\u5316\u89e3\u6bd2\u7d20\u53ca\u5132\u5b58\u8840\u7cd6\u7b49\u591a\u7a2e\u529f\u80fd\u3002\u60a3\u6709\u4e59\u578b\u809d\u708e\u3001\u8102\u80aa\u809d\u6216\u904e\u91cf\u670d\u7528\u6b62\u75db\u85e5\u90fd\u6703\u5c0d\u809d\u81df\u9020\u6210\u640d\u5bb3\u3002\u96d6\u7136\u809d\u81df\u6709\u91cd\u751f\u80fd\u529b\uff0c\u4f46\u91cd\u8907\u640d\u50b7\u53ca\u4fee\u5fa9\uff0c\u6703\u9020\u6210\u4e0d\u65b7\u7684\u300c\u7d50\u75a4\u300d\uff0c\u5f15\u81f4\u809d\u786c\u5316\uff0c\u82e5\u5728\u4fee\u5fa9\u671f\u9593\u7d30\u80de\u51fa\u932f\uff0c\u4fbf\u6709\u6a5f\u6703\u5f62\u6210\u809d\u764c\uff0c\u6700\u4f73\u7684\u8b77\u809d\u65b9\u6cd5\u662f\u8b93\u809d\u81df\u4f11\u606f\u3002<\/p>\n

 <\/p>\n

\u809d\u764c\u8207\u4e59\u809d\u6709\u95dc<\/h2>\n

\u5927\u90e8\u5206\u809d\u764c\u8207\u4e59\u578b\u809d\u708e\u6709\u95dc\uff0c\u9999\u6e2f\u5e73\u5747\u6bcf\u516b\u81f3\u5341\u4eba\u4fbf\u6709\u4e00\u540d\u809d\u708e\u5e36\u83cc\u8005\u3002\u60a3\u8005\u61c9\u8981\u6bcf\u516d\u500b\u6708\u6aa2\u9a57\u8840\u6db2\u53ca\u809d\u529f\u80fd\uff0c\u800c\u6bcf\u65e5\u670d\u7528\u85e5\u7269\u63a7\u5236\u809d\u708e\uff0c\u53ef\u4ee4\u60a3\u809d\u764c\u6a5f\u6703\u6e1b\u534a\u3002\u990a\u548c\u91ab\u9662\u809d\u81df\u5916\u79d1\u53ca\u79fb\u690d\u4e2d\u5fc3\u3001\u5916\u79d1\u540d\u8b7d\u9867\u554f\u91ab\u751f\u9673\u8a69\u6b63\u91ab\u751f\u8868\u793a\uff0c\u4e59\u578b\u809d\u708e\u6216\u8102\u80aa\u809d\u60a3\u8005\uff0c\u60a3\u4e0a\u809d\u764c\u7684\u6bd4\u4f8b\u9ad8\u65bc\u5e38\u4eba100\u500d\uff0c\u82e5\u52a0\u4e0a\u540c\u6642\u60a3\u6709\u4e19\u578b\u809d\u708e\u6216\u6709\u98f2\u9152\u7fd2\u6163\uff0c\u60a3\u809d\u764c\u6a5f\u6703\u66f4\u9ad8\u3002\u65e9\u671f\u60a3\u8005\u53ef\u9032\u884c\u6839\u6cbb\u624b\u8853\uff0c\u4f46\u5f8c\u671f\u60a3\u8005\u56e0\u70ba\u764c\u7d30\u80de\u6709\u6a5f\u6703\u7d93\u8840\u7ba1\u64f4\u6563\u81f3\u8eab\u9ad4\u5176\u4ed6\u90e8\u4f4d\uff0c\u624b\u8853\u5f8c\u4ea6\u6709\u76f8\u7576\u7684\u5fa9\u767c\u98a8\u96aa\u3002<\/p>\n

 <\/p>\n

\u65b0\u5100\u5668\u63d0\u5347\u624b\u8853\u6210\u6548<\/h2>\n

\u624b\u8853\u671f\u9593\u70ba\u6e1b\u4f4e\u764c\u7d30\u80de\u9032\u5165\u8840\u7ba1\u53ca\u5931\u8840\u60c5\u6cc1\uff0c\u6703\u76e1\u91cf\u4ee5\u4e0d\u63a5\u89f8\u809d\u81df\u7684\u65b9\u6cd5\u5207\u9664\u764c\u7d30\u80de\u3002\u9673\u91ab\u751f\u8868\u793a\uff0c\u73fe\u6642\u6703\u5229\u7528\u8d85\u8072\u5200\u9032\u884c\u524d\u5207\u9664\u624b\u8853\uff0c\u5229\u7528\u8d85\u8072\u6ce2\u7206\u7834\u809d\u7d30\u80de\uff0c\u6e1b\u5c11\u5931\u8840\u53ca\u8f38\u8840\u9700\u8981\u3002\u9673\u91ab\u751f\u6307\uff1a\u300c\u8fd1\u5e74\u66f4\u4e0d\u4e4f\u65b0\u5100\u5668\uff0c\u6709\u52a9\u63d0\u5347\u5207\u9664\u6548\u7387\u53ca\u6e1b\u5c11\u60a3\u8005\u5931\u8840\u53ca\u8f38\u8840\u60c5\u6cc1\uff0c\u4e26\u63d0\u5347\u5b58\u6d3b\u7387\u3002\u300d<\/p>\n

\u82e5\u60a3\u8005\u809d\u529f\u80fd\u8f03\u5dee\uff0c\u56e0\u809d\u786c\u5316\u53ca\u809d\u81df\u7e2e\u5c0f\u800c\u7121\u6cd5\u9032\u884c\u5207\u9664\u624b\u8853\uff0c\u53ef\u9078\u64c7\u9032\u884c\u809d\u81df\u79fb\u690d\u624b\u8853\uff0c\u6709\u516b\u6210\u6a5f\u6703\u6cbb\u7652\u809d\u764c\u3002\u9673\u91ab\u751f\u6307\u51fa\uff0c\u7531\u65bc\u9999\u6e2f\u907a\u9ad4\u6350\u8d08\u809d\u81df\u6578\u91cf\u4e0d\u591a\uff0c\u56e0\u6b64\u8f03\u5e38\u63a1\u53d6\u6d3b\u809d\u79fb\u690d\uff0c\u6350\u8d08\u8005\u82e5\u8207\u60a3\u8005\u9ad4\u578b\u76f8\u82e5\uff0c\u9700\u6350\u51fa\u4e09\u5206\u4e8c\u7684\u809d\u81df\uff0c\u4e26\u67090.5%\u7684\u6b7b\u4ea1\u98a8\u96aa\uff0c\u56e0\u6b64\u9700\u614e\u91cd\u8003\u616e\u3002<\/p>\n

\u6b64\u5916\uff0c\u4ea6\u6709\u5c04\u983b\u6cbb\u7642\u5c07\u91dd\u523a\u9032\u816b\u7624\u4e2d\u5fc3\u4f4d\u7f6e\uff0c\u5229\u7528\u71b1\u529b\u6467\u6bc0\u764c\u7d30\u80de\uff0c\u60df\u523a\u91dd\u6709\u6a5f\u6703\u5c07\u764c\u7d30\u80de\u63a8\u5411\u8840\u7ba1\uff0c\u4e00\u822c\u8f03\u5c11\u4f7f\u7528\u6b64\u65b9\u6cd5\u3002<\/p>\n

 <\/p>\n

\u3010\u809d\u764c\u3011\u6cbb\u7642\u809d\u764c\u65b0\u8f49\u6a5f \u5fae\u5275\u624b\u8853\u3001\u65b0\u85e5\u7269\u5c0d\u4ed8\u816b\u7624\u898b\u6210\u6548<\/a><\/p>\n

 <\/p>\n

\"\u990a\u548c\u91ab\u9662,\u809d\u764c,\u8b1b\u5ea7\"
\u53c3\u52a0\u300c\u809d\u764c\u8a3a\u7642\u65b0\u8da8\u52e2\u300d\u8b1b\u5ea7\u8005\u773e\uff0c\u4ee5\u4e86\u89e3\u9632\u60a3\u53ca\u6cbb\u7642\u809d\u764c\u7684\u6700\u65b0\u8cc7\u8a0a\u3002<\/figcaption><\/figure>\n

 <\/p>\n

\u65b0\u85e5\u5e36\u4f86\u6cbb\u7642\u5e0c\u671b<\/h2>\n

\u975e\u624b\u8853\u6cbb\u7642\u5728\u904e\u53bb\u6578\u5e74\u6709\u8457\u7ffb\u5929\u8986\u5730\u7684\u8b8a\u5316\uff0c\u80fd\u6709\u6548\u5ef6\u9577\u58fd\u547d\uff0c\u6539\u5584\u751f\u6d3b\u8cea\u7d20\u3002\u990a\u548c\u91ab\u9662\u5167\u79d1\u816b\u7624\u79d1\u540d\u8b7d\u9867\u554f\u91ab\u751f\u3001\u809d\u81df\u79d1\u540d\u8b7d\u9867\u554f\u91ab\u751f\u6881\u60e0\u68e0\u91ab\u751f\u8868\u793a\uff0c\u975e\u624b\u8853\u6cbb\u7642\u9069\u5408\u8f03\u5f8c\u671f\u7684\u809d\u764c\u60a3\u8005\uff0c\u53ef\u5229\u7528\u4ecb\u5165\u6cbb\u7642\u91dd\u5c0d\u672a\u64f4\u6563\u4f46\u7121\u6cd5\u5207\u9664\u7684\u809d\u81df\u816b\u7624\u3002<\/p>\n

 <\/p>\n

\u5176\u4e2d\uff0cTACE\u8840\u7ba1\u6813\u585e\u5316\u7642\u662f\u50b3\u7d71\u4ecb\u5165\u6cbb\u7642\uff0c\u5c07\u7898\u6cb9\u6df7\u5408\u5316\u7642\u85e5\u7269\u6ce8\u5c04\u5165\u809d\u52d5\u8108\uff0c\u518d\u914d\u5408\u8840\u7ba1\u6813\u585e\u6b65\u9a5f\uff0c\u53ef\u6e1b\u5c11\u85e5\u7269\u6d41\u5931\uff0c\u9054\u5230\u6cbb\u7642\u6548\u679c\u3002\u8fd1\u5e74\u5247\u4ee5\u5e36\u85e5\u5fae\u7403\u4ecb\u5165\u6cbb\u7642\u53d6\u4ee3\uff0c\u900f\u904e\u8840\u7ba1\u9020\u5f71\u5c07\u5e36\u85e5\u5fae\u7403\u6ce8\u5165\u816b\u7624\uff0c\u9010\u5c11\u91cb\u653e\u6297\u764c\u85e5\u7269\uff0c\u4ee4\u816b\u7624\u58de\u6b7b\uff0c\u597d\u8655\u662f\u526f\u4f5c\u7528\u8f03\u5c11\uff0c\u7642\u6548\u8f03\u9ad8\u3002<\/p>\n

 <\/p>\n

\u53e6\u5916\uff0c\u9084\u6709\u91d4-90\u5fae\u7c92\u5167\u653e\u5c04\u6cbb\u7642\uff0c\u5c07\u5177\u653e\u5c04\u6027\u7684\u91d4-90\u5fae\u7c92\u6ce8\u5165\u816b\u7624\u8840\u7ba1\u5167\u6d88\u6ec5\u764c\u7d30\u80de\uff0c\u80fd\u6cbb\u7642\u7279\u5927\u809d\u764c\u7d30\u80de\uff0c\u4e00\u6b21\u7642\u7a0b\u5df2\u53ef\u9054\u5230\u76f8\u61c9\u6548\u679c\u3002\u914d\u5408\u5291\u91cf\u63a7\u5236\u53ca\u8b93\u5408\u9069\u7684\u75c5\u4eba\u4f7f\u7528\uff0c\u6cbb\u7642\u6548\u679c\u66f4\u7406\u60f3\u3002
\n\u91dd\u5c0d\u764c\u7d30\u80de\u8f49\u79fb\uff0c\u73fe\u6642\u4ea6\u6709\u591a\u7a2e\u6a19\u9776\u85e5\u9078\u64c7\u3002\u7d22\u62c9\u975e\u5c3c\uff08Sorafenib\uff09\u662f\u9996\u500b\u7372\u7f8e\u570bFDA\u6838\u51c6\u6cbb\u7642\u809d\u764c\u7684\u6a19\u9776\u85e5\uff0c\u80fd\u9a37\u64fe\u7d30\u80de\u50b3\u5c0e\uff0c\u963b\u6b62\u8840\u7ba1\u751f\u6210\uff0c\u4ee4\u7d30\u80de\u7f3a\u4e4f\u990a\u5206\u800c\u51cb\u4ea1\uff0c\u7d93\u81e8\u7240\u7814\u7a76\u5c0d\u64f4\u6563\u6027\u809d\u764c\uff0c\u6bd4\u670d\u7528\u5b89\u6170\u5291\u66f4\u80fd\u5ef6\u9577\u58fd\u547d\u3002\u5176\u4ed6\u6a19\u9776\u85e5\u9084\u5305\u62ec\u8c9d\u4f10\u73e0\u55ae\u6297\uff08Bevacizumab\uff09\u3001\u66ff\u897f\u7f85\u83ab\u65af\uff08Temsirolimus\uff09\u7b49\u3002<\/p>\n

 <\/p>\n

\u6881\u91ab\u751f\u8868\u793a\uff0c\u8fd1\u5e74\u9084\u6709\u65b0\u7684\u6297\u809d\u764c\u6a19\u9776\u85e5\u51fa\u73fe\uff0c\u4f8b\u5982\u6a02\u4f10\u66ff\u5c3c\uff08Lenvatinib\uff09\u662f\u4e00\u7a2e\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff0c\u816b\u7624\u6536\u7e2e\u6bd4\u7387\u8f03\u7d22\u62c9\u975e\u5c3c\u70ba\u9ad8\uff0c\u4e8c\u7dda\u6a19\u9776\u85e5\u5361\u535a\u66ff\u5c3c\uff08Cabozantinib\uff09\u7684\u5b58\u6d3b\u7387
\n\u4ea6\u9054\u523012\u500b\u6708\u3002<\/p>\n

 <\/p>\n

\u514d\u75ab\u6cbb\u7642\u589e\u5b58\u6d3b\u7387<\/h2>\n

\u514d\u75ab\u6cbb\u7642\u5728\u6cbb\u7642\u764c\u75c7\u65b9\u9762\u4ea6\u6108\u898b\u6210\u6548\u3002\u7d0d\u6b66\u55ae\u6297\uff08Nivolumab\uff09\u80fd\u5920\u559a\u9192T\u7d30\u80de\uff0c\u4ee5\u8fa8\u8a8d\u764c\u7d30\u80de\u53ca\u5411\u5176\u653b\u64ca\uff0c\u534a\u6578\u4eba\u9054\u5230\u809d\u764c\u63a7\u5236\u7684\u6210\u6548\uff0c\u5b58\u6d3b\u7387\u7531\u4e00\u822c\u7684\u516d\u81f3\u516b\u500b\u6708\uff0c\u5e73\u5747\u589e\u81f314\u500b\u6708\u3002\u6700\u8fd1\uff0c\u7f8e\u570b\u6709\u5831\u544a\u986f\u793a\uff0c\u9032\u884c\u96d9\u514d\u75ab\u6cbb\u7642\uff08\u4f7f\u7528\u5169\u7a2e\u514d\u75ab\u6cbb\u7642\u85e5\u7269\uff09\u5c0d\u816b\u7624\u6536\u7e2e\u66f4\u6709\u6210\u6548\uff0c\u5b58\u6d3b\u7387\u589e\u81f317\u81f322\u500b\u6708\u3002\u6881\u91ab\u751f\u5f37\u8abf\uff0c\u670980\u591a\u6b72\u7684\u5a46\u5a46\u63a5\u53d7\u514d\u75ab\u6cbb\u7642\u5f8c\u816b\u7624\u6d88\u5931\uff0c8\u81f312\u500b\u6708\u90fd\u672a\u898b\u816b\u7624\u51fa\u73fe\uff0c\u53ef\u56de\u5fa9\u6b63\u5e38\u751f\u6d3b\uff0c\u56e0\u6b64\u4e0d\u8981\u56e0\u70ba\u7121\u6cd5\u9032\u884c\u624b\u8853\u800c\u611f\u5230\u7d55\u671b\u3002<\/p>\n

 <\/p>\n

\u76f8\u95dc\u6587\u7ae0: <\/strong><\/p>\n

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