{"id":15997,"date":"2018-12-17T16:12:46","date_gmt":"2018-12-17T08:12:46","guid":{"rendered":"\/\/www.afterroberto.com\/?p=15997"},"modified":"2019-06-28T16:20:05","modified_gmt":"2019-06-28T08:20:05","slug":"%e5%88%86%e5%ad%90%e8%85%ab%e7%98%a4%e5%b0%88%e5%ae%b6%e7%b5%84-%e6%8b%86%e8%a7%a3%e5%9f%ba%e5%9b%a0%e5%af%86%e7%a2%bc-%e5%ba%a6%e8%ba%ab%e8%a8%ad%e8%a8%88%e6%b2%bb%e7%99%8c","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e5%88%86%e5%ad%90%e8%85%ab%e7%98%a4%e5%b0%88%e5%ae%b6%e7%b5%84-%e6%8b%86%e8%a7%a3%e5%9f%ba%e5%9b%a0%e5%af%86%e7%a2%bc-%e5%ba%a6%e8%ba%ab%e8%a8%ad%e8%a8%88%e6%b2%bb%e7%99%8c\/","title":{"rendered":"\u5206\u5b50\u816b\u7624\u5c08\u5bb6\u7d44 \u62c6\u89e3\u57fa\u56e0\u5bc6\u78bc \u5ea6\u8eab\u8a2d\u8a08\u6cbb\u764c"},"content":{"rendered":"<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u5206\u5b50\u751f\u7269\u79d1\u6280\u767c\u5c55\u4e00\u65e5\u5343\u91cc\uff0c\u65b0\u6280\u8853\u3001\u65b0\u767c\u73fe\u5c0d\u81e8\u7240\u91ab\u5b78\u7684\u5f71\u97ff\u6108\u4f86\u6108\u5927\uff1b\u5c24\u5176\u662f\u816b\u7624\u91ab\u5b78\uff0c\u5728\u751f\u7269\u5206\u5b50\u79d1\u5b78\u7684\u61c9\u7528\u4e0a\u53ef\u8b02\u7ad9\u5728\u6700\u524d\u7dda\u3002\u300c\u5206\u5b50\u816b\u7624\u5c08\u5bb6\u7d44\u300d\uff08Molecular Tumor Board, MTB\uff09\u7531\u816b\u7624\u79d1\u91ab\u751f\u3001\u75c5\u7406\u79d1\u91ab\u751f\u3001\u91ab\u5b78\u907a\u50b3\u5b78\u5bb6\u3001\u816b\u7624\u57fa\u56e0\u79d1\u5b78\u5bb6\u3001\u751f\u7269\u4fe1\u606f\u5b78\u5c08\u5bb6\u548c\u85e5\u7406\u5c08\u5bb6\u7d44\u6210\uff0c\u5206\u6790\u5229\u7528\u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff08NGS\uff09\u7684\u816b\u7624\u57fa\u56e0\uff0c\u5c0b\u627e\u6cbb\u7642\u65b9\u6848\u53ca\u8ffd\u8e64\u7528\u85e5\u5f8c\u53cd\u61c9\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/12\/cancer-DNA.webp \"  type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/12\/cancer-DNA.jpg\" class=\" sp-no-webp\" alt=\"NGS,DNA,\u816b\u7624\u57fa\u56e0\u6392\u5e8f,\u764c\u75c7,\u816b\u7624,\u5206\u5b50\u816b\u7624\u5c08\u5bb6\u7d44,\u6797\u6cf0\u5fe0,\u816b\u7624\u79d1,\u9999\u6e2f\u5927\u5b78\u81e8\u7240\u816b\u7624\u79d1,\" decoding=\"async\"  > <\/picture><br \/>\n<span class=\"caption\">\u500b\u4eba\u5316\u6cbb\u7642\u2014\u2014\u628a\u75c5\u4eba\u816b\u7624\u7d44\u7e54\u9001\u5230\u5be6\u9a57\u5ba4\u505aNGS\u6392\u5e8f\uff0c\u6392\u5e8f\u5f8c\u7684\u8907\u96dc\u57fa\u56e0\u5bc6\u78bc\u6703\u7d93\u904e\u751f\u7269\u4fe1\u606f\u5b78\u5206\u6790\uff0c\u518d\u7de8\u8f2f\u6210\u5831\u544a\u4f5c\u81e8\u7240\u53c3\u8003\u3002\uff08\u660e\u5831\u88fd\u5716\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u8eab\u9ad4\u6bcf\u500b\u6b63\u5e38\u7d30\u80de\u7684\u904b\u4f5c\uff0c\u90fd\u662f\u7531\u6975\u4e4b\u7cbe\u5bc6\u7684\u57fa\u56e0\u7cfb\u7d71\u6240\u63a7\u5236\uff0c\u4ee4\u6bcf\u500b\u7d30\u80de\u4e92\u76f8\u914d\u5408\u6210\u70ba\u4e00\u9ad4\u3002\u800c\u816b\u7624\u7684\u5f62\u6210\u3001\u751f\u9577\u548c\u64f4\u6563\uff0c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u7531\u65bc\u9019\u500b\u8907\u96dc\u7684\u57fa\u56e0\u7cfb\u7d71\u51fa\u73fe\u4e86\u7a81\u8b8a\uff0c\u4ee4\u672c\u4f86\u6709\u79e9\u5e8f\u7684\u65b0\u9673\u4ee3\u8b1d\u51fa\u73fe\u554f\u984c\u800c\u5931\u53bb\u63a7\u5236\u3002<\/p>\n<p>\u4eba\u985e\u57281950\u5e74\u4ee3\u767c\u73fe\u57fa\u56e0\u7684\u57fa\u672c\u55ae\u4f4dDNA\uff0c\u751f\u547d\u7684\u79d8\u5bc6\u5c31\u860a\u85cf\u5728DNA\uff08A\/T\/G\/C\uff09\u7d44\u6210\u7684\u5bc6\u78bc\u4e4b\u4e2d\u3002\u7531\u65bc\u7576\u5e74\u89e3\u8b80\u5bc6\u78bc\uff08DNA\u6392\u5e8f\uff09\u7684\u751f\u7269\u5316\u9a57\u76f8\u7576\u7e41\u8907\u548c\u6602\u8cb4\uff0c\u4eba\u985e\u57281970\u5e74\u624d\u767c\u73fe\u7b2c\u4e00\u500b\u81f4\u764c\u57fa\u56e0\uff08SRC\uff09\u3002\u76f4\u52302000\u5e74\uff0c\u96c6\u5408\u5168\u7403\u751f\u7269\u79d1\u6280\u529b\u91cf\uff0c\u4eba\u985e\u6574\u500b\u57fa\u56e0\u5716\u8b5c\u7684\u6392\u5e8f\u624d\u9996\u6b21\u5b8c\u6210\uff0c\u5171\u767c\u73fe\u4e86\u7d0420,000\u500b\u57fa\u56e0\u3002\u7136\u800c\u9019\u53ea\u662f\u7b2c\u4e00\u6b65\uff0c\u8b6f\u51fa\u5bc6\u78bc\u4e26\u4e0d\u7b49\u65bc\u660e\u767d\u5bc6\u78bc\u80cc\u5f8c\u7684\u529f\u80fd\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/12\/NGS.jpg\" alt=\"NGS,DNA,\u816b\u7624\u57fa\u56e0\u6392\u5e8f,\u764c\u75c7,\u816b\u7624,\u5206\u5b50\u816b\u7624\u5c08\u5bb6\u7d44,\u6797\u6cf0\u5fe0,\u816b\u7624\u79d1,\u9999\u6e2f\u5927\u5b78\u81e8\u7240\u816b\u7624\u79d1,\" title=\"\"><br \/>\n<span class=\"caption\">\u500b\u4eba\u5316\u6cbb\u7642\u2014\u2014\u628a\u75c5\u4eba\u816b\u7624\u7d44\u7e54\u9001\u5230\u5be6\u9a57\u5ba4\u505aNGS\u6392\u5e8f\uff0c\u6392\u5e8f\u5f8c\u7684\u8907\u96dc\u57fa\u56e0\u5bc6\u78bc\u6703\u7d93\u904e\u751f\u7269\u4fe1\u606f\u5b78\u5206\u6790\uff0c\u518d\u7de8\u8f2f\u6210\u5831\u544a\u4f5c\u81e8\u7240\u53c3\u8003\u3002\uff08jxfzsy@iStockphoto\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2>NGS\u6392\u5e8f\u6210\u672c\u5927\u964d 4\u5468\u6709\u7d50\u679c<\/h2>\n<p>\u5728\u6280\u8853\u6c34\u5e73\u7684\u9650\u5236\u4e0b\uff0c\u76f4\u81f321\u4e16\u7d00\u982d10\u5e74\uff0c\u5206\u5b50\u751f\u7269\u5b78\u5728\u81e8\u7240\u751f\u7269\u5b78\u4e0a\u7684\u61c9\u7528\uff0c\u53ea\u9650\u65bc\u500b\u5225\u3001\u55ae\u4e00\u7684\u57fa\u56e0\u5206\u6790\uff0c\u5c0d\u5927\u90e8\u5206\u816b\u7624\u75c5\u4eba\u7684\u6cbb\u7642\u6c92\u6709\u76f4\u63a5\u5f71\u97ff\u3002\u5c0d\u540c\u4e00\u6e90\u982d\u3001\u540c\u4e00\u5206\u671f\u7684\u816b\u7624\uff0c\u6bcf\u4e00\u500b\u75c5\u4eba\u7684\u6cbb\u7642\u65b9\u6848\u90fd\u662f\u4e00\u6a23\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u76f4\u52302000\u5e74\u5de6\u53f3\uff0c\u5206\u5b50\u751f\u7269\u5b78\u5c0d\u57fa\u56e0\u6392\u5e8f\u6280\u8853\u53d6\u5f97\u7a81\u7834\uff1b\u6392\u5e8f\u6210\u672c\u5f9e2008\u5e74\u958b\u59cb\u5927\u5e45\u4e0b\u964d\uff0c\u4f7fDNA\u6392\u5e8f\u7684\u6e96\u78ba\u5ea6\u3001\u901f\u5ea6\u5927\u5e45\u63d0\u5347\uff0c\u5f9e\u800c\u9010\u6f38\u9032\u5165\u81e8\u7240\u61c9\u7528\u968e\u6bb5\u3002\u5229\u7528\u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff08next generation sequencing\uff0cNGS\u3002\u76f8\u95dc\u5831\u9053\uff1agoo.gl\/3CA57v\uff09\u4f5c\u500b\u5225\u75c5\u4eba\u6a23\u672c\u7684\u5168\u9762DNA\u6392\u5e8f\uff0c\u6240\u9700\u6642\u9593\u7531\u5e7e\u500b\u6708\u7e2e\u6e1b\u5230\u4e00\u5929\u4ee5\u5167\uff0c\u6210\u672c\u4ea6\u4ee5\u5e7e\u4f55\u7d1a\u6578\u4e0b\u964d\u3002\u5206\u5b50\u816b\u7624\u5b78\u7814\u7a76\u767c\u5c55\u52a0\u5feb\u4e86\uff0c\u65b0\u85e5\u7269\u7814\u7a76\u7684\u6548\u7387\u4e5f\u63d0\u9ad8\u4e86\uff0cNGS\u6280\u8853\u4f7f\u500b\u4eba\u5316\u816b\u7624\u6cbb\u7642\u9032\u5165\u81e8\u7240\u4f7f\u7528\u6210\u70ba\u53ef\u80fd\u3002\u7f8e\u570b\u98df\u54c1\u53ca\u85e5\u7269\u7ba1\u7406\u5c40\u57282017\u5e74\u6b63\u5f0f\u8a8d\u53ef\u9996\u500bNGS\u816b\u7624\u57fa\u56e0\u6392\u5e8f\u5e73\u53f0\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>NGS\u816b\u7624\u57fa\u56e0\u6392\u5e8f\u548c\u7cbe\u6e96\u6cbb\u7642\u5df2\u7d93\u5f15\u5165\u9999\u6e2f\u3002\u5728\u5f97\u5230\u75c5\u4eba\u7684\u540c\u610f\u5f8c\uff0c\u816b\u7624\u79d1\u91ab\u751f\u53ef\u4ee5\u628a\u75c5\u4eba\u7684\u816b\u7624\u7d44\u7e54\u9001\u5f80\u6d77\u5916\u7684\u5be6\u9a57\u5ba4\u505aNGS\u6392\u5e8f\u3002\u73fe\u6642\u7684NGS\u6392\u5e8f\u90fd\u662f\u7531\u5546\u696d\u516c\u53f8\u7d93\u71df\uff0c\u4e0d\u540c\u7684\u5e73\u53f0\u5728\u6280\u8853\u5c64\u9762\u4e0a\u7a0d\u6709\u4e0d\u540c\uff0c\u4f46\u5927\u81f4\u90fd\u5305\u62ec\u7d04300\u81f3500\u5e38\u898b\u7684\u81f4\u75c5\u57fa\u56e0\u3002\u6392\u5e8f\u5f8c\u7684\u8907\u96dc\u57fa\u56e0\u5bc6\u78bc\u6703\u7d93\u904e\u751f\u7269\u4fe1\u606f\u5b78\uff08bioinformatics\uff09\u5206\u6790\uff0c\u518d\u7de8\u8f2f\u6210\u5831\u544a\u4f5c\u81e8\u7240\u53c3\u8003\u3002\u5f9e\u75c5\u4eba\u7c3d\u7f72\u540c\u610f\u66f8\u5230\u5206\u6790\u5831\u544a\u5b8c\u6210\uff0c\u7d04\u97004\u5468\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/12\/NGS1.jpg\" alt=\"NGS,DNA,\u816b\u7624\u57fa\u56e0\u6392\u5e8f,\u764c\u75c7,\u816b\u7624,\u5206\u5b50\u816b\u7624\u5c08\u5bb6\u7d44,\u6797\u6cf0\u5fe0,\u816b\u7624\u79d1,\u9999\u6e2f\u5927\u5b78\u81e8\u7240\u816b\u7624\u79d1,\" title=\"\"><br \/>\n<span class=\"caption\">\u4f9d\u5831\u544a\u8a2d\u8a08\u2014\u2014\u816b\u7624\u79d1\u91ab\u751f\u6839\u64daNGS\u7684\u5206\u6790\u5831\u544a\uff0c\u70ba\u75c5\u4eba\u8a2d\u8a08\u500b\u4eba\u5316\u7684\u816b\u7624\u6cbb\u7642\u65b9\u6848\u3002\uff08noipornpan@iStockphoto\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2>\u589e\u52a0\u8a8d\u77e5\u764c\u7d30\u80de\u751f\u7269\u7279\u5fb5<\/h2>\n<p>\u816b\u7624\u79d1\u91ab\u751f\u53ef\u4ee5\u6839\u64da\u5831\u544a\u7684\u5efa\u8b70\uff0c\u70ba\u75c5\u4eba\u8a2d\u8a08\u500b\u4eba\u5316\u7684\u816b\u7624\u6cbb\u7642\u65b9\u6848\u3002\u4f8b\u5982\u80ba\u764c\u7d30\u80de\u82e5\u5e36\u6709\u4e00\u7a2e\u76ae\u819a\u764c\u5e38\u898b\u7684\u57fa\u56e0\u7a81\u8b8a\uff08BRAF V600E\uff09\uff0c\u8a72\u80ba\u764c\u75c5\u4eba\u4fbf\u53ef\u4ee5\u8003\u616e\u4f7f\u7528\u91dd\u5c0d\u76ae\u819a\u764cBRAF\u7684\u85e5\u7269\u3002\u9664\u4e86\u6a19\u9776\u6cbb\u7642\u4ee5\u5916\uff0c\u90e8\u5206NGS\u5831\u544a\u4ea6\u6703\u5206\u6790\u816b\u7624\u5c0d\u514d\u75ab\u6cbb\u7642\u6216\u4e0d\u540c\u5316\u7642\u7684\u654f\u611f\u5ea6\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u900f\u904e\u5148\u9032\u7684NGS\u6392\u5e8f\u79d1\u6280\uff0c\u91ab\u751f\u5927\u5927\u589e\u52a0\u4e86\u5c0d\u764c\u7d30\u80de\u751f\u7269\u7279\u5fb5\u7684\u8a8d\u77e5\uff0c\u4ee4\u90e8\u5206\u75c5\u4eba\u5728\u81e8\u7240\u6cbb\u7642\u4e0a\u76f4\u63a5\u7372\u76ca\u3002\u4f46\u662f\u751f\u7269\u8cc7\u8a0a\u7684\u589e\u52a0\uff0c\u540c\u6642\u4e5f\u5e36\u4f86\u4e00\u4e9b\u96e3\u984c\u3002\u9996\u5148\uff0cNGS\u7684\u7d50\u679c\u53ef\u80fd\u548c\u4e00\u4e9b\u50b3\u7d71\u5316\u9a57\u5831\u544a\u4e0d\u8117\u5408\uff0c\u4e0d\u540c\u5e73\u53f0\u7684\u6280\u8853\u548c\u54c1\u8cea\u63a7\u5236\u4e5f\u6709\u53c3\u5dee\u3002\u540c\u4e00\u500b\u57fa\u56e0\u5167\uff0c\u4e0d\u540c\u4f4d\u7f6e\u3001\u4e0d\u540c\u7a2e\u985e\u7684\u7a81\u8b8a\uff0c\u5c0d\u57fa\u56e0\u7684\u529f\u80fd\u4ee5\u81f3\u764c\u75c7\u7684\u7279\u5fb5\u90fd\u6703\u6709\u622a\u7136\u4e0d\u540c\u7684\u5f71\u97ff\u3002\u6b64\u5916\uff0c\u5982\u4f55\u6f14\u7e79NGS\u5831\u544a\u7684\u7528\u85e5\u5efa\u8b70\u4ea6\u5927\u6709\u5b78\u554f\u3002\u4e00\u500b\u816b\u7624\u53ef\u80fd\u5e36\u6709\u591a\u500b\u57fa\u56e0\u8b8a\u5316\uff0c\u7a76\u7adf\u61c9\u8a72\u91dd\u5c0d\u54ea\u4e00\u7a2e\u8b8a\u5316\u7528\u85e5\uff0c\u9084\u662f\u591a\u85e5\u4e00\u8d77\u4f7f\u7528\uff0c\u73fe\u6642\u4e26\u6c92\u6709\u5f88\u597d\u7684\u6307\u5f15\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u8ffd\u8e64\u5206\u6790\u7528\u85e5\u5f8c\u53cd\u61c9<\/h2>\n<p>\u9762\u5c0d\u4ee5\u4e0a\u96e3\u984c\uff0c\u9999\u6e2f\u5927\u5b78\u91ab\u7642\u7cfb\u7d71\uff08HKU Health System\uff09\u6210\u7acb\u4e86\u5206\u5b50\u816b\u7624\u5c08\u5bb6\u7d44MTB\uff0c\u5e6b\u52a9\u524d\u7dda\u816b\u7624\u79d1\u91ab\u751f\u66f4\u597d\u767c\u63ee\u5206\u5b50\u751f\u7269\u91ab\u5b78\u7684\u81e8\u7240\u50f9\u503c\u3002MTB\u7684\u5c08\u5bb6\u6bcf\u6708\u5b9a\u671f\u958b\u6703\uff0c\u8a0e\u8ad6NGS\u6392\u5e8f\u500b\u6848\u4e26\u91dd\u5c0d\u6bcf\u500b\u500b\u6848\u4f5c\u51fa\u5206\u6790\u7e3d\u7d50\uff0c\u4ea6\u6703\u5c0d\u500b\u6848\u7528\u85e5\u5f8c\u7684\u53cd\u61c9\u8ffd\u8e64\u5206\u6790\u3002MTB\u5728\u6d77\u5916\u7684\u5927\u578b\u816b\u7624\u4e2d\u5fc3\u5df2\u662f\u5e38\u898f\u670d\u52d9\u4e4b\u4e00\uff0c\u5c0d\u63a8\u9032\u500b\u4eba\u5316\u816b\u7624\u6cbb\u7642\u6709\u91cd\u8981\u7684\u529f\u80fd\u3002\u6e2f\u5927\u5e0c\u671b\u900f\u904eMTB\u63d0\u9ad8\u672c\u5730\u7684\u816b\u7624\u91ab\u5b78\u6c34\u5e73\uff0c\u6b61\u8fce\u5168\u6e2f\u816b\u7624\u79d1\u91ab\u751f\u8f49\u4ecb\u500b\u6848\u8a0e\u8ad6\u7814\u7a76\u3002\u200b<\/p>\n<p>&nbsp;<\/p>\n<p>\u6587\uff1a\u6797\u6cf0\u5fe0\uff08<a href=\"https:\/\/www.hku.hk\/c_index.html\" target=\"_blank\" rel=\"noopener\">\u9999\u6e2f\u5927\u5b78<\/a>\u81e8\u7240\u816b\u7624\u79d1\u81e8\u7240\u52a9\u7406\u6559\u6388\uff09<\/p>\n<p>\u7de8\u8f2f\uff1a\u6881\u5c0f\u73b2<\/p>\n<p>\u96fb\u90f5\uff1a<a href=\"mailto:feature@mingpao.com\">feature@mingpao.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u5206\u5b50\u751f\u7269\u79d1\u6280\u767c\u5c55\u4e00\u65e5\u5343\u91cc\uff0c\u65b0\u6280\u8853\u3001\u65b0\u767c\u73fe\u5c0d\u81e8\u7240\u91ab\u5b78\u7684\u5f71\u97ff\u6108\u4f86\u6108\u5927\uff1b\u5c24\u5176\u662f\u816b\u7624\u91ab\u5b78\uff0c\u5728\u751f\u7269\u5206\u5b50\u79d1\u5b78\u7684\u61c9\u7528\u4e0a\u53ef\u8b02\u7ad9\u5728\u6700\u524d\u7dda\u3002\u300c\u5206\u5b50\u816b\u7624\u5c08\u5bb6\u7d44\u300d\uff08Molecular Tumor Board, MTB\uff09\u7531\u816b\u7624\u79d1\u91ab\u751f\u3001\u75c5\u7406\u79d1\u91ab\u751f\u3001\u91ab\u5b78\u907a\u50b3\u5b78\u5bb6\u3001\u816b\u7624\u57fa\u56e0\u79d1\u5b78\u5bb6\u3001\u751f\u7269\u4fe1\u606f\u5b78\u5c08\u5bb6\u548c\u85e5\u7406\u5c08\u5bb6\u7d44\u6210\uff0c\u5206\u6790\u5229\u7528\u6b21\u4e16\u4ee3\u5b9a\u5e8f\uff08NGS\uff09\u7684\u816b\u7624\u57fa\u56e0\uff0c\u5c0b\u627e\u6cbb\u7642\u65b9\u6848\u53ca\u8ffd\u8e64\u7528\u85e5\u5f8c\u53cd\u61c9\u3002 &nbsp; \u500b\u4eba\u5316\u6cbb\u7642\u2014\u2014\u628a\u75c5\u4eba\u816b\u7624\u7d44\u7e54\u9001\u5230\u5be6\u9a57\u5ba4\u505aNGS\u6392\u5e8f\uff0c\u6392\u5e8f\u5f8c\u7684\u8907\u96dc\u57fa\u56e0\u5bc6\u78bc\u6703\u7d93\u904e\u751f\u7269\u4fe1\u606f\u5b78\u5206\u6790\uff0c\u518d\u7de8\u8f2f\u6210\u5831\u544a\u4f5c\u81e8\u7240\u53c3\u8003\u3002\uff08\u660e\u5831\u88fd\u5716\uff09 &nbsp; \u8eab\u9ad4\u6bcf\u500b\u6b63\u5e38\u7d30\u80de\u7684\u904b\u4f5c\uff0c\u90fd\u662f\u7531\u6975\u4e4b\u7cbe\u5bc6\u7684\u57fa\u56e0\u7cfb\u7d71\u6240\u63a7\u5236\uff0c\u4ee4\u6bcf\u500b\u7d30\u80de\u4e92\u76f8\u914d\u5408\u6210\u70ba\u4e00\u9ad4\u3002\u800c\u816b\u7624\u7684\u5f62\u6210\u3001\u751f\u9577\u548c\u64f4\u6563\uff0c\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u7531\u65bc\u9019\u500b\u8907\u96dc\u7684\u57fa\u56e0\u7cfb\u7d71\u51fa\u73fe\u4e86\u7a81\u8b8a\uff0c\u4ee4\u672c\u4f86\u6709\u79e9\u5e8f\u7684\u65b0\u9673\u4ee3\u8b1d\u51fa\u73fe\u554f\u984c\u800c\u5931\u53bb\u63a7\u5236\u3002 \u4eba\u985e\u57281950\u5e74\u4ee3\u767c\u73fe\u57fa\u56e0\u7684\u57fa\u672c\u55ae\u4f4dDNA\uff0c\u751f\u547d\u7684\u79d8\u5bc6\u5c31\u860a\u85cf\u5728DNA\uff08A\/T\/G\/C\uff09\u7d44\u6210\u7684\u5bc6\u78bc\u4e4b\u4e2d\u3002\u7531\u65bc\u7576\u5e74\u89e3\u8b80\u5bc6\u78bc\uff08DNA\u6392\u5e8f\uff09\u7684\u751f\u7269\u5316\u9a57\u76f8\u7576\u7e41\u8907\u548c\u6602\u8cb4\uff0c\u4eba\u985e\u57281970\u5e74\u624d\u767c\u73fe\u7b2c\u4e00\u500b\u81f4\u764c\u57fa\u56e0\uff08SRC\uff09\u3002\u76f4\u52302000\u5e74\uff0c\u96c6\u5408\u5168\u7403\u751f\u7269\u79d1\u6280\u529b\u91cf\uff0c\u4eba\u985e\u6574\u500b\u57fa\u56e0\u5716\u8b5c\u7684\u6392\u5e8f\u624d\u9996\u6b21\u5b8c\u6210\uff0c\u5171\u767c\u73fe\u4e86\u7d0420,000\u500b\u57fa\u56e0\u3002\u7136\u800c\u9019\u53ea\u662f\u7b2c\u4e00\u6b65\uff0c\u8b6f\u51fa\u5bc6\u78bc\u4e26\u4e0d\u7b49\u65bc\u660e\u767d\u5bc6\u78bc\u80cc\u5f8c\u7684\u529f\u80fd\u3002 &nbsp; \u500b\u4eba\u5316\u6cbb\u7642\u2014\u2014\u628a\u75c5\u4eba\u816b\u7624\u7d44\u7e54\u9001\u5230\u5be6\u9a57\u5ba4\u505aNGS\u6392\u5e8f\uff0c\u6392\u5e8f\u5f8c\u7684\u8907\u96dc\u57fa\u56e0\u5bc6\u78bc\u6703\u7d93\u904e\u751f\u7269\u4fe1\u606f\u5b78\u5206\u6790\uff0c\u518d\u7de8\u8f2f\u6210\u5831\u544a\u4f5c\u81e8\u7240\u53c3\u8003\u3002\uff08jxfzsy@iStockphoto\uff09 &nbsp; NGS\u6392\u5e8f\u6210\u672c\u5927\u964d 4\u5468\u6709\u7d50\u679c \u5728\u6280\u8853\u6c34\u5e73\u7684\u9650\u5236\u4e0b\uff0c\u76f4\u81f321\u4e16\u7d00\u982d10\u5e74\uff0c\u5206\u5b50\u751f\u7269\u5b78\u5728\u81e8\u7240\u751f\u7269\u5b78\u4e0a\u7684\u61c9\u7528\uff0c\u53ea\u9650\u65bc\u500b\u5225\u3001\u55ae\u4e00\u7684\u57fa\u56e0\u5206\u6790\uff0c\u5c0d\u5927\u90e8\u5206\u816b\u7624\u75c5\u4eba\u7684\u6cbb\u7642\u6c92\u6709\u76f4\u63a5\u5f71\u97ff\u3002\u5c0d\u540c\u4e00\u6e90\u982d\u3001\u540c\u4e00\u5206\u671f\u7684\u816b\u7624\uff0c\u6bcf\u4e00\u500b\u75c5\u4eba\u7684\u6cbb\u7642\u65b9\u6848\u90fd\u662f\u4e00\u6a23\u3002 &nbsp; 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sequencing\uff0cNGS\u3002\u76f8\u95dc\u5831\u9053\uff1agoo.gl\/3CA57v\uff09\u4f5c\u500b\u5225\u75c5\u4eba\u6a23\u672c\u7684\u5168\u9762DNA\u6392\u5e8f\uff0c\u6240\u9700\u6642\u9593\u7531\u5e7e\u500b\u6708\u7e2e\u6e1b\u5230\u4e00\u5929\u4ee5\u5167\uff0c\u6210\u672c\u4ea6\u4ee5\u5e7e\u4f55\u7d1a\u6578\u4e0b\u964d\u3002\u5206\u5b50\u816b\u7624\u5b78\u7814\u7a76\u767c\u5c55\u52a0\u5feb\u4e86\uff0c\u65b0\u85e5\u7269\u7814\u7a76\u7684\u6548\u7387\u4e5f\u63d0\u9ad8\u4e86\uff0cNGS\u6280\u8853\u4f7f\u500b\u4eba\u5316\u816b\u7624\u6cbb\u7642\u9032\u5165\u81e8\u7240\u4f7f\u7528\u6210\u70ba\u53ef\u80fd\u3002\u7f8e\u570b\u98df\u54c1\u53ca\u85e5\u7269\u7ba1\u7406\u5c40\u57282017\u5e74\u6b63\u5f0f\u8a8d\u53ef\u9996\u500bNGS\u816b\u7624\u57fa\u56e0\u6392\u5e8f\u5e73\u53f0\u3002 &nbsp; NGS\u816b\u7624\u57fa\u56e0\u6392\u5e8f\u548c\u7cbe\u6e96\u6cbb\u7642\u5df2\u7d93\u5f15\u5165\u9999\u6e2f\u3002\u5728\u5f97\u5230\u75c5\u4eba\u7684\u540c\u610f\u5f8c\uff0c\u816b\u7624\u79d1\u91ab\u751f\u53ef\u4ee5\u628a\u75c5\u4eba\u7684\u816b\u7624\u7d44\u7e54\u9001\u5f80\u6d77\u5916\u7684\u5be6\u9a57\u5ba4\u505aNGS\u6392\u5e8f\u3002\u73fe\u6642\u7684NGS\u6392\u5e8f\u90fd\u662f\u7531\u5546\u696d\u516c\u53f8\u7d93\u71df\uff0c\u4e0d\u540c\u7684\u5e73\u53f0\u5728\u6280\u8853\u5c64\u9762\u4e0a\u7a0d\u6709\u4e0d\u540c\uff0c\u4f46\u5927\u81f4\u90fd\u5305\u62ec\u7d04300\u81f3500\u5e38\u898b\u7684\u81f4\u75c5\u57fa\u56e0\u3002\u6392\u5e8f\u5f8c\u7684\u8907\u96dc\u57fa\u56e0\u5bc6\u78bc\u6703\u7d93\u904e\u751f\u7269\u4fe1\u606f\u5b78\uff08bioinformatics\uff09\u5206\u6790\uff0c\u518d\u7de8\u8f2f\u6210\u5831\u544a\u4f5c\u81e8\u7240\u53c3\u8003\u3002\u5f9e\u75c5\u4eba\u7c3d\u7f72\u540c\u610f\u66f8\u5230\u5206\u6790\u5831\u544a\u5b8c\u6210\uff0c\u7d04\u97004\u5468\u3002 &nbsp; 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