{"id":15839,"date":"2018-12-04T10:45:20","date_gmt":"2018-12-04T02:45:20","guid":{"rendered":"\/\/www.afterroberto.com\/?p=15839"},"modified":"2019-05-14T12:33:01","modified_gmt":"2019-05-14T04:33:01","slug":"%e9%86%ab%e8%a8%80%e6%9c%89%e7%90%86%ef%bc%9a%e9%87%8d%e7%b7%a8%e5%9f%ba%e5%9b%a0%e5%bd%b1%e9%9f%bf%e5%be%8c%e4%bb%a3","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e9%86%ab%e8%a8%80%e6%9c%89%e7%90%86%ef%bc%9a%e9%87%8d%e7%b7%a8%e5%9f%ba%e5%9b%a0%e5%bd%b1%e9%9f%bf%e5%be%8c%e4%bb%a3\/","title":{"rendered":"\u91ab\u8a00\u6709\u7406\uff1a\u91cd\u7de8\u57fa\u56e0\u5f71\u97ff\u5f8c\u4ee3"},"content":{"rendered":"<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u8fd1\u671f\u57ce\u4e2d\u71b1\u8ac7\uff0c\u6709\u79d1\u5b78\u5bb6\u70ba\u611b\u6ecb\u75c5\u7236\u6bcd\u6240\u7522\u751f\u7684\u80da\u80ce\u9032\u884c\u57fa\u56e0\u6392\u5e8f\u91cd\u7de8\uff0c\u76ee\u7684\u662f\u9632\u6b62\u5b30\u5152\u5c07\u4f86\u53d7\u5230\u611b\u6ecb\u75c5\u6bd2\u611f\u67d3\uff0c\u4e8b\u4ef6\u5f15\u767c\u4e0d\u5c11\u502b\u7406\u554f\u984c\u3002\u5927\u5bb6\u95dc\u6ce8\u5b30\u5152\u51fa\u751f\u524d\u4e26\u6c92\u6709\u80fd\u529b\u540c\u610f\u63a5\u53d7\u9019\u9805\u8a66\u9a57\uff0c\u91cd\u7de8\u57fa\u56e0\u53ef\u80fd\u8a98\u767c\u4e0d\u826f\u53cd\u61c9\uff0c\u4e26\u5c0d\u5f80\u5f8c\u7684\u5b50\u5b6b\u5f8c\u4ee3\u6240\u9020\u6210\u7684\u6f5b\u5728\u5f71\u97ff\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/12\/DNA-2.jpg\" alt=\"\" title=\"\"><br \/>\n<span class=\"caption\">(\u7db2\u4e0a\u5716\u7247\/\u660e\u5831\u88fd\u5716)<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u7236\u89aa\u7684\u300c\u7cbe\u5b50\u300d\uff08Sperm\uff09\u548c\u6bcd\u89aa\u7684\u300c\u5375\u5b50\u300d\uff08Egg\uff09\u7d50\u5408\u6210\u70ba\u300c\u80da\u80ce\u300d\uff08Embryo\uff09\uff0c\u5167\u542b\u300c\u57fa\u56e0\u5bc6\u78bc\u300d\uff08Genetic 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silencing\uff09\u4f7f\u7528\u907a\u50b3\u6280\u8853\u4f86\u964d\u4f4e\u57fa\u56e0\u7684\u8868\u9054\u6c34\u5e73\u3002<\/p>\n<p>\u9019\u4e9b\u57fa\u56e0\u79d1\u6280\u53ef\u61c9\u7528\u65bc\u4e0d\u540c\u985e\u578b\u7684\u7d30\u80de\uff0c\u9ad4\u5916\u7d30\u80de\u7684\u57fa\u56e0\u53d7\u5230\u6539\u8b8a\uff0c\u56de\u8f38\u5165\u60a3\u8005\u9ad4\u5167\uff0c\u53ef\u4f5c\u6cbb\u7642\u75be\u75c5\u4e4b\u7528\u3002\u55ae\u4e00\u57fa\u56e0\u51fa\u73fe\u8b8a\u7570\u800c\u81f4\u75c5\uff08Single gene defect\uff09\uff0c\u5982\u7f3a\u4e4f\u300c\u7b2c\u516b\u8840\u51dd\u56fa\u56e0\u5b50\u300d\uff08Factor VIII\uff09\u7684\u300c\u8840\u53cb\u75c5\u300d\uff08Haemophilia\uff09\uff0c\u300c\u57fa\u56e0\u6cbb\u7642\u300d\u53ef\u63d0\u4f9b\u4e00\u500b\u6b63\u5e38\u7684\u57fa\u56e0\uff0c\u53d6\u4ee3\u672c\u8eab\u5df2\u8b8a\u7570\u7684\u57fa\u56e0\u3002<\/p>\n<p>\u57fa\u56e0\u6280\u8853\u4ea6\u53ef\u61c9\u7528\u65bc\u300c\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u300d\uff08Cancer immunotherapy\uff09\uff0c\u4f8b\u5982\u300c\u5d4c\u5408\u6297\u539f\u53d7\u9ad4T\u7d30\u80de\u300d\uff08Chimeric Antigen Receptor T Cells, CAR-T\uff09\uff1b\u91ab\u751f\u70ba\u60a3\u8005\u7684T\u7d30\u80de\u52a0\u5165CD19\u300c\u5d4c\u5408\u6297\u539f\u53d7\u9ad4\u300d\uff0c\u4ee4T\u7d30\u80de\u5177\u80fd\u529b\u653b\u64ca\u81ea\u8eab\u9ad4\u5167\u542bCD19\u7684\u764c\u7d30\u80de\uff0c\u53ef\u6709\u6548\u63a7\u5236\u591a\u7a2e\u6025\u6027\u6dcb\u5df4\u767d\u8840\u75c5\u53ca\u6dcb\u5df4\u764c\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u91cd\u7de8\u57fa\u56e0\u5217\u5e8f\u51fa\u932f \u6216\u8a98\u767c\u764c\u75c7<\/h2>\n<p>\u8ddf\u57fa\u56e0\u6cbb\u7642\u7a0d\u6709\u4e0d\u540c\uff0c\u300c\u91cd\u7de8\u57fa\u56e0\u5217\u5e8f\u300d\u6d89\u53ca\u76f4\u63a5\u6539\u8b8a\u7d30\u80de\u5167\u539f\u6709\u57fa\u56e0\u7d44\u7684\u5217\u5e8f\uff0c\u6280\u8853\u66f4\u52a0\u8907\u96dc\u3002\u300c\u91cd\u7de8\u57fa\u56e0\u5217\u5e8f\u300d\u5229\u7528\u300c\u5167\u5207\u6838\u9178\u9176\u300d\uff08Endonuclease\uff09\u5207\u5272\u6389\u67d0\u6bb5\u4e0d\u826f\u7684\u57fa\u56e0\uff0c\u7136\u5f8c\u5c07\u5169\u500b\u5207\u5272\u672b\u7aef\u5408\u4f75\u6216\u4fee\u5fa9\u3002\u5728\u4fee\u5fa9\u904e\u7a0b\u4e2d\uff0c\u539f\u6709\u7684\u57fa\u56e0\u88ab\u65b0\u7684\u57fa\u56e0\u5217\u5e8f\u6240\u53d6\u4ee3\u3002\u5207\u5272\u548c\u4fee\u5fa9\u7684\u7cbe\u78ba\u5ea6\u5fc5\u9808\u6975\u9ad8\uff0c\u907f\u514d\u51fa\u73fe\u932f\u8aa4\u7684\u57fa\u56e0\u5217\u5e8f\uff0c\u56e0\u800c\u5f15\u767c\u4e0d\u826f\u5f8c\u679c\uff1b\u300c\u81f4\u764c\u57fa\u56e0\u300d\uff08Oncogene\uff09\u3001\u300c\u816b\u7624\u6291\u5236\u57fa\u56e0\u300d\uff08Tumour suppressor gene\uff09\u6216\u300cDNA\u4fee\u5fa9\u57fa\u56e0\u300d\uff08DNA repair gene\uff09\u53d7\u5230\u7834\u58de\uff0c\u7686\u6709\u6a5f\u6703\u8a98\u767c\u764c\u75c7\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6587\uff1a\u6881\u61b2\u5b6b\uff08\u8840\u6db2\u53ca\u8840\u6db2\u816b\u7624\u79d1\u5c08\u79d1\u91ab\u751f)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u8fd1\u671f\u57ce\u4e2d\u71b1\u8ac7\uff0c\u6709\u79d1\u5b78\u5bb6\u70ba\u611b\u6ecb\u75c5\u7236\u6bcd\u6240\u7522\u751f\u7684\u80da\u80ce\u9032\u884c\u57fa\u56e0\u6392\u5e8f\u91cd\u7de8\uff0c\u76ee\u7684\u662f\u9632\u6b62\u5b30\u5152\u5c07\u4f86\u53d7\u5230\u611b\u6ecb\u75c5\u6bd2\u611f\u67d3\uff0c\u4e8b\u4ef6\u5f15\u767c\u4e0d\u5c11\u502b\u7406\u554f\u984c\u3002\u5927\u5bb6\u95dc\u6ce8\u5b30\u5152\u51fa\u751f\u524d\u4e26\u6c92\u6709\u80fd\u529b\u540c\u610f\u63a5\u53d7\u9019\u9805\u8a66\u9a57\uff0c\u91cd\u7de8\u57fa\u56e0\u53ef\u80fd\u8a98\u767c\u4e0d\u826f\u53cd\u61c9\uff0c\u4e26\u5c0d\u5f80\u5f8c\u7684\u5b50\u5b6b\u5f8c\u4ee3\u6240\u9020\u6210\u7684\u6f5b\u5728\u5f71\u97ff\u3002 &nbsp; (\u7db2\u4e0a\u5716\u7247\/\u660e\u5831\u88fd\u5716) &nbsp; \u7236\u89aa\u7684\u300c\u7cbe\u5b50\u300d\uff08Sperm\uff09\u548c\u6bcd\u89aa\u7684\u300c\u5375\u5b50\u300d\uff08Egg\uff09\u7d50\u5408\u6210\u70ba\u300c\u80da\u80ce\u300d\uff08Embryo\uff09\uff0c\u5167\u542b\u300c\u57fa\u56e0\u5bc6\u78bc\u300d\uff08Genetic codes\uff09\uff0c\u63a7\u5236\u7d30\u80de\u86cb\u767d\u8cea\u7684\u88fd\u9020\u53ca\u65b0\u9673\u4ee3\u8b1d\uff0c\u5f9e\u800c\u64cd\u7e31\u7d30\u80de\u529f\u80fd\u3002\u7d30\u80de\u57fa\u56e0\u5bc6\u78bc\u4e00\u534a\u4f86\u81ea\u7236\u89aa\uff0c\u4e00\u534a\u4f86\u81ea\u6bcd\u89aa\uff0c\u5171\u540c\u6c7a\u5b9a\u5b30\u5152\u51fa\u751f\u5f8c\u7684\u9ad4\u8cea\u548c\u5f62\u614b\u3002 \u57fa\u56e0\u79d1\u6280\u4e00\u65e5\u5343\u91cc\uff0c\u73fe\u5df2\u6709\u591a\u7a2e\u65b9\u6cd5\u6539\u8b8a\u7d30\u80de\u7684\u300c\u57fa\u56e0\u6392\u5217\u300d\uff08Gene sequences\uff09\uff0c\u751a\u81f3\u63a7\u5236\u7d30\u80de\u88fd\u9020\u67d0\u7a2e\u86cb\u767d\u8cea\u7684\u529f\u80fd\uff0c\u5305\u62ec\u300c\u57fa\u56e0\u6cbb\u7642\u300d\uff08Gene therapy\uff09\u70ba\u7d30\u80de\u5f15\u5165\u65b0\u57fa\u56e0\u3001\u300c\u91cd\u7de8\u57fa\u56e0\u5217\u5e8f\u300d\uff08Gene editing\uff09\u66f4\u6539\u57fa\u56e0\u7684\u539f\u6709\u6392\u5217\u3001\u300c\u57fa\u56e0\u6c89\u9ed8\u300d\uff08Gene silencing\uff09\u4f7f\u7528\u907a\u50b3\u6280\u8853\u4f86\u964d\u4f4e\u57fa\u56e0\u7684\u8868\u9054\u6c34\u5e73\u3002 \u9019\u4e9b\u57fa\u56e0\u79d1\u6280\u53ef\u61c9\u7528\u65bc\u4e0d\u540c\u985e\u578b\u7684\u7d30\u80de\uff0c\u9ad4\u5916\u7d30\u80de\u7684\u57fa\u56e0\u53d7\u5230\u6539\u8b8a\uff0c\u56de\u8f38\u5165\u60a3\u8005\u9ad4\u5167\uff0c\u53ef\u4f5c\u6cbb\u7642\u75be\u75c5\u4e4b\u7528\u3002\u55ae\u4e00\u57fa\u56e0\u51fa\u73fe\u8b8a\u7570\u800c\u81f4\u75c5\uff08Single gene defect\uff09\uff0c\u5982\u7f3a\u4e4f\u300c\u7b2c\u516b\u8840\u51dd\u56fa\u56e0\u5b50\u300d\uff08Factor VIII\uff09\u7684\u300c\u8840\u53cb\u75c5\u300d\uff08Haemophilia\uff09\uff0c\u300c\u57fa\u56e0\u6cbb\u7642\u300d\u53ef\u63d0\u4f9b\u4e00\u500b\u6b63\u5e38\u7684\u57fa\u56e0\uff0c\u53d6\u4ee3\u672c\u8eab\u5df2\u8b8a\u7570\u7684\u57fa\u56e0\u3002 \u57fa\u56e0\u6280\u8853\u4ea6\u53ef\u61c9\u7528\u65bc\u300c\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u300d\uff08Cancer immunotherapy\uff09\uff0c\u4f8b\u5982\u300c\u5d4c\u5408\u6297\u539f\u53d7\u9ad4T\u7d30\u80de\u300d\uff08Chimeric Antigen Receptor T Cells, CAR-T\uff09\uff1b\u91ab\u751f\u70ba\u60a3\u8005\u7684T\u7d30\u80de\u52a0\u5165CD19\u300c\u5d4c\u5408\u6297\u539f\u53d7\u9ad4\u300d\uff0c\u4ee4T\u7d30\u80de\u5177\u80fd\u529b\u653b\u64ca\u81ea\u8eab\u9ad4\u5167\u542bCD19\u7684\u764c\u7d30\u80de\uff0c\u53ef\u6709\u6548\u63a7\u5236\u591a\u7a2e\u6025\u6027\u6dcb\u5df4\u767d\u8840\u75c5\u53ca\u6dcb\u5df4\u764c\u3002 &nbsp; \u91cd\u7de8\u57fa\u56e0\u5217\u5e8f\u51fa\u932f \u6216\u8a98\u767c\u764c\u75c7 \u8ddf\u57fa\u56e0\u6cbb\u7642\u7a0d\u6709\u4e0d\u540c\uff0c\u300c\u91cd\u7de8\u57fa\u56e0\u5217\u5e8f\u300d\u6d89\u53ca\u76f4\u63a5\u6539\u8b8a\u7d30\u80de\u5167\u539f\u6709\u57fa\u56e0\u7d44\u7684\u5217\u5e8f\uff0c\u6280\u8853\u66f4\u52a0\u8907\u96dc\u3002\u300c\u91cd\u7de8\u57fa\u56e0\u5217\u5e8f\u300d\u5229\u7528\u300c\u5167\u5207\u6838\u9178\u9176\u300d\uff08Endonuclease\uff09\u5207\u5272\u6389\u67d0\u6bb5\u4e0d\u826f\u7684\u57fa\u56e0\uff0c\u7136\u5f8c\u5c07\u5169\u500b\u5207\u5272\u672b\u7aef\u5408\u4f75\u6216\u4fee\u5fa9\u3002\u5728\u4fee\u5fa9\u904e\u7a0b\u4e2d\uff0c\u539f\u6709\u7684\u57fa\u56e0\u88ab\u65b0\u7684\u57fa\u56e0\u5217\u5e8f\u6240\u53d6\u4ee3\u3002\u5207\u5272\u548c\u4fee\u5fa9\u7684\u7cbe\u78ba\u5ea6\u5fc5\u9808\u6975\u9ad8\uff0c\u907f\u514d\u51fa\u73fe\u932f\u8aa4\u7684\u57fa\u56e0\u5217\u5e8f\uff0c\u56e0\u800c\u5f15\u767c\u4e0d\u826f\u5f8c\u679c\uff1b\u300c\u81f4\u764c\u57fa\u56e0\u300d\uff08Oncogene\uff09\u3001\u300c\u816b\u7624\u6291\u5236\u57fa\u56e0\u300d\uff08Tumour suppressor gene\uff09\u6216\u300cDNA\u4fee\u5fa9\u57fa\u56e0\u300d\uff08DNA repair gene\uff09\u53d7\u5230\u7834\u58de\uff0c\u7686\u6709\u6a5f\u6703\u8a98\u767c\u764c\u75c7\u3002 &nbsp; \u6587\uff1a\u6881\u61b2\u5b6b\uff08\u8840\u6db2\u53ca\u8840\u6db2\u816b\u7624\u79d1\u5c08\u79d1\u91ab\u751f)<\/p>\n","protected":false},"author":5,"featured_media":15843,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_lock_modified_date":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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