{"id":15400,"date":"2018-10-22T12:03:33","date_gmt":"2018-10-22T04:03:33","guid":{"rendered":"\/\/www.afterroberto.com\/?p=15400"},"modified":"2019-06-27T13:49:26","modified_gmt":"2019-06-27T05:49:26","slug":"%e6%b8%af%e7%94%a2%e7%a0%94%e7%a9%b6%e6%94%b9%e5%af%ab%e6%8a%97%e7%99%8c%e5%8f%b2-%e6%99%9a%e6%9c%9f%e8%82%ba%e7%99%8c-%e7%99%82%e6%b3%95%e5%a4%9a%e5%85%83%e5%80%8b%e4%ba%ba%e5%8c%96","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e6%b8%af%e7%94%a2%e7%a0%94%e7%a9%b6%e6%94%b9%e5%af%ab%e6%8a%97%e7%99%8c%e5%8f%b2-%e6%99%9a%e6%9c%9f%e8%82%ba%e7%99%8c-%e7%99%82%e6%b3%95%e5%a4%9a%e5%85%83%e5%80%8b%e4%ba%ba%e5%8c%96\/","title":{"rendered":"\u6e2f\u7522\u7814\u7a76\u6539\u5beb\u6297\u764c\u53f2 \u665a\u671f\u80ba\u764c \u7642\u6cd5\u591a\u5143\u500b\u4eba\u5316"},"content":{"rendered":"<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u6b63\u5728\u5fb7\u570b\u6155\u5c3c\u9ed1\u8209\u884c\u7684\u6b50\u6d32\u816b\u7624\u5b78\u5b78\u6703\uff08ESMO 2018\uff09\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u816b\u7624\u5b78\u7cfb\u7cfb\u4e3b\u4efb\u83ab\u6a39\u9326\u7372\u9812\u767c\u7d42\u8eab\u6210\u5c31\u734e\uff0c\u8868\u5f70\u4ed6\u662f\u5168\u7403\u7b2c\u4e00\u4eba\u628a\u751f\u7269\u6a19\u8a18\u61c9\u7528\u65bc\u80ba\u764c\u7814\u7a76\u3002<\/p>\n<p><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/lungcancer.webp \"  type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/lungcancer.jpg\" class=\" sp-no-webp\" alt=\"\u80ba\u764c\" decoding=\"async\" title=\"\u6e2f\u7522\u7814\u7a76\u6539\u5beb\u6297\u764c\u53f2 \u665a\u671f\u80ba\u764c \u7642\u6cd5\u591a\u5143\u500b\u4eba\u5316\"  > <\/picture><br \/>\n<span class=\"caption\">\uff08\u660e\u5831\u88fd\u5716\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u81ea\u5f9e\u7b2c\u4e00\u500b\u80ba\u764c\u751f\u7269\u6a19\u8a18\u300c\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u300d\uff08EGFR\uff09\u61c9\u7528\u65bc\u75c5\u4eba\u8eab\u4e0a\uff0c\u5728\u904e\u53bb\u77ed\u77ed10\u5e74\u9593\uff0c\u65b0\u7684\u751f\u7269\u6a19\u8a18\u548c\u91dd\u5c0d\u7684\u6a19\u9776\u85e5\u7269\u9678\u7e8c\u51fa\u73fe\uff0c\u52a0\u4e0a\u8fd1\u5e74\u71b1\u9580\u7684\u514d\u75ab\u6cbb\u7642\uff0c\u665a\u671f\u80ba\u764c\u6cbb\u7642\u662f\u5426\u5df2\u6bcb\u9808\u5316\u7642\uff1f\u6a19\u9776\u6cbb\u7642\u548c\u514d\u75ab\u6cbb\u7642\uff0c\u53c8\u61c9\u5982\u4f55\u9078\u64c7\uff1f<\/p>\n<p>&nbsp;<\/p>\n<p>\u672a\u6709\u6a19\u9776\u6cbb\u7642\u4e4b\u524d\uff0c\u80ba\u764c\u4e3b\u8981\u4ee5\u7d30\u80de\u5b78\u5206\u985e\uff08\u898b\u8868\u4e00\uff09\uff0c\u5316\u7642\u662f\u5c0d\u4ed8\u665a\u671f\u764c\u75c7\u552f\u4e00\u65b9\u6cd5\uff0c\u5373\u5229\u7528\u85e5\u7269\u7834\u58de\u8fc5\u901f\u751f\u9577\u7684\u764c\u7d30\u80de\uff0c\u4f46\u540c\u6642\u50b7\u53ca\u6b63\u5e38\u7d30\u80de\u3002\u5316\u7642\u75c5\u4eba\u5e73\u5747\u5b58\u6d3b\u671f\u53ea\u6709\u6578\u6708\u3002<\/p>\n<p>\u83ab\u6a39\u9326\u9818\u5c0e\u7684IPASS\uff08IRESSA Pan-Asia Study\uff09\u7814\u7a76\uff0c\u662f\u80ba\u764c\u500b\u4eba\u5316\u6cbb\u7642\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002<\/p>\n<p><img decoding=\"async\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/lungcancer-a.jpg\" alt=\"\" title=\"\"><br \/>\n<span class=\"caption\">\uff08\u660e\u5831\u88fd\u5716\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2>\u6709\u75c5\u4eba\u7528\u85e5\u903e10\u5e74 \u80ba\u764c\u53ef\u6cbb\u7642<\/h2>\n<p>IPASS\u662f\u4ee5\u4e9e\u6d32\u3001\u975e\u5438\u7159\u3001\u80ba\u817a\u764c\u60a3\u8005\u70ba\u7814\u7a76\u5c0d\u8c61\uff0c\u662f\u5168\u7403\u7b2c\u4e00\u500b\u7814\u7a76\u8b49\u5be6\uff0c\u5e36\u6709EGFR\u7a81\u8b8a\u7684\u80ba\u764c\u75c5\u4eba\uff0c\u4f7f\u7528\u6a19\u9776\u85e5\u5409\u975e\u66ff\u5c3c\uff08Gefitinib\uff09\uff0c\u6548\u679c\u6bd4\u5316\u7642\u7d44\u5408\u5361\u9251\uff0f\u7d2b\u6749\u9187\u512a\u52dd\u3002\u5409\u975e\u66ff\u5c3c\u56e0\u6b64\u6210\u70ba\u4e00\u7dda\u6cbb\u7642\uff0c\u6539\u5beb\u4e86\u80ba\u764c\u6cbb\u7642\u7684\u6b77\u53f2\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7e7cEGFR\u4e4b\u5f8c\uff0c\u5176\u4ed6\u9a45\u52d5\u764c\u57fa\u56e0\u53ca\u76f8\u95dc\u6a19\u9776\u85e5\u7269\u9678\u7e8c\u51fa\u73fe\uff0c\u80ba\u764c\u4e0d\u518d\u662f\u55ae\u4e00\u75be\u75c5\u3001\u55ae\u4e00\u6cbb\u7642\uff08\u898b\u8868\u4e8c\uff09\u3002\u73fe\u5728\u78ba\u8a3a\u665a\u671f\u80ba\u764c\u75c5\u4eba\uff0c\u9996\u5148\u8981\u63a5\u53d7\u57fa\u56e0\u6e2c\u8a66\uff0c\u624d\u6c7a\u5b9a\u6cbb\u7642\u65b9\u6848\u3002\u516c\u7acb\u91ab\u9662\u6703\u70ba\u75c5\u4eba\u6aa2\u6e2c\u6700\u5e38\u898b\u5169\u7a2e\u9a45\u52d5\u764c\u57fa\u56e0\uff1aEGFR\u53caALK\u3002<\/p>\n<p><img decoding=\"async\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/lungcancer-b.jpg\" alt=\"\" title=\"\"><br \/>\n<span class=\"caption\">\uff08\u660e\u5831\u88fd\u5716\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u4ee5\u4e9e\u6d32\u4eba\u5e38\u898b\u7684EGFR\u7a81\u8b8a\u70ba\u4f8b\uff0c\u6a19\u9776\u85e5\u7269\u5df2\u63a8\u51fa\u81f3\u7b2c\u4e09\u4ee3\uff0c\u6709\u7b2c\u4e00\u4ee3\u7684\u5409\u975e\u66ff\u5c3c\uff08Gefitinib\uff09\u548c\u5384\u6d1b\u66ff\u5c3c\uff08Erlotinib\uff09\u3001\u7b2c\u4e8c\u4ee3\u7684\u963f\u6cd5\u66ff\u5c3c\uff08Afatinib\uff09\uff0c\u4ee5\u53ca\u7b2c\u4e09\u4ee3\u7684\u5967\u5e0c\u66ff\u5c3c\uff08Osimertinib\uff09\u3002\u83ab\u6a39\u9326\u89e3\u91cb\uff0c\u7b2c\u4e8c\u4ee3\u7684\u85e5\u6548\u8f03\u7b2c\u4e00\u4ee3\u5f37\uff0c\u4f46\u76f8\u5c0d\u6bd2\u6027\u4ea6\u9ad8\uff0c\u6240\u4ee5\u6703\u5efa\u8b70\u7528\u65bc\u8f03\u5e74\u8f15\u75c5\u4eba\uff0c\u8001\u5f31\u75c5\u4eba\u5247\u7528\u7b2c\u4e00\u4ee3\u3002\u7576\u670d\u7528\u7b2c\u4e00\u4ee3\u85e5\u7269\u4e00\u6bb5\u6642\u9593\u5f8c\u51fa\u73feT790M\u57fa\u56e0\u8b8a\u7570\uff0c\u5c31\u53ef\u8f49\u7528\u7b2c\u4e09\u4ee3\u85e5\u7269\u3002\u300c\u5df2\u6709\u665a\u671f\u80ba\u764c\u75c5\u4eba\u7528\u85e5\u8d85\u904e10\u5e74\uff0c\u80ba\u764c\u5df2\u6210\u70ba\u53ef\u6cbb\u7642\u7684\u75be\u75c5\u3002\u300d<\/p>\n<p>&nbsp;<\/p>\n<p>\u53e6\u4e00\u5e38\u898b\u9a45\u52d5\u764c\u57fa\u56e0ALK\uff0c\u4ea6\u67093\u7a2e\u6a19\u9776\u85e5\uff0c\u514b\u5511\u66ff\u5c3c\uff08Crizotinib\uff09\u662f\u4e00\u7dda\u6a19\u6e96\u7642\u6cd5\uff0c\u7576\u75c5\u4eba\u51fa\u73fe\u6297\u85e5\u6027\uff0c\u91ab\u751f\u6703\u8003\u616e\u4f7f\u7528\u65b0\u85e5\u827e\u6a02\u66ff\u5c3c\uff08Alectinib\uff09\u3002\u800c\u83ab\u6a39\u9326\u9818\u5c0e\u7684\u570b\u969b\u7814\u7a76\u6bd4\u8f03\u5169\u85e5\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u7684\u529f\u6548\uff0c\u986f\u793a\u4f7f\u7528\u827e\u6a02\u66ff\u5c3c\u7684\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u70ba34.8\u500b\u6708\uff0c\u8f03\u514b\u5511\u66ff\u5c3c\u768411\u500b\u6708\u9577\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/lungcancer-c.jpg\" alt=\"\" title=\"\"><br \/>\n<span class=\"caption\">\u7372\u7d42\u8eab\u6210\u5c31\u734e\u2014\u2014\u5728\u4e0a\u5468\u4e94\u5fb7\u570b\u6155\u5c3c\u9ed1\u8209\u884c\u7684\u6b50\u6d32\u816b\u7624\u5b78\u5b78\u6703\u5e74\u6703\uff0c\u83ab\u6a39\u9326\u7372\u9812\u7d42\u8eab\u6210\u5c31\u734e\u5f8c\u767c\u8868\u6f14\u8aaa\u3002\uff08\u912d\u5bf6\u83ef\u651d\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n<h2>\u6c92\u6709\u9a45\u52d5\u764c\u57fa\u56e0 \u53ef\u7528\u514d\u75ab\u6cbb\u7642\u6216\u5316\u7642<\/h2>\n<p>\u82e5\u75c5\u4eba\u627e\u5230\u4e0a\u8ff0\u5169\u7a2e\u9a45\u52d5\u764c\u57fa\u56e0\uff0c\u6cbb\u7642\u9078\u64c7\u8f03\u591a\uff1b\u4f46\u81f3\u65bc\u5176\u4ed6\u4e0d\u5e38\u898b\u7684\u57fa\u56e0\uff0c\u6aa2\u6e2c\u8207\u5426\u4ecd\u7136\u5b58\u6709\u722d\u8b70\u3002\u83ab\u6a39\u9326\u89e3\u91cb\uff0c\u56e0\u70ba\u4e0d\u5e38\u898b\uff0c\u70ba\u6240\u6709\u80ba\u764c\u75c5\u4eba\u505a\u6aa2\u6e2c\u4f3c\u4e4e\u4e0d\u5408\u4e4e\u6210\u672c\u6548\u76ca\uff0c\u4ed6\u5efa\u8b70\u78ba\u8a3a\u80ba\u817a\u764c\u75c5\u4eba\uff0c\u82e5\u627e\u4e0d\u5230EGFR\u53caALK\uff0c\u624d\u8003\u616e\u6aa2\u6e2c\u5176\u4ed65\u7a2e\u4e0d\u5e38\u898b\u7684\u9a45\u52d5\u764c\u57fa\u56e0\uff1a\u5305\u62ecROS1\u3001BRAF\u3001HER2\u3001RET\u3001MET\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u300c\u5982\u679c\u627e\u5230EGFR\u53caALK\uff0c\u7b2c\u4e00\u7dda\u6cbb\u7642\u662f\u6a19\u9776\u85e5\uff1b\u82e5\u662f\u627e\u5230\u5176\u4ed6\u4e0d\u5e38\u898b\u7684\u57fa\u56e0\uff0c\u5c31\u6709\u4e0d\u540c\u8003\u616e\uff08\u898b\u4e3b\u5716\uff09\u3002\u300d\u83ab\u89e3\u91cb\uff0c\u76ee\u524d\u53ea\u6709\u91dd\u5c0dBRAF\u548cROS1\u7684\u6a19\u9776\u85e5\u7372FDA\u5be9\u6279\uff0c\u5176\u4ed6\u7684\u4ecd\u5728\u7814\u7a76\u5be6\u9a57\u968e\u6bb5\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u5982\u679c\u627e\u4e0d\u5230\u4efb\u4f55\u9a45\u52d5\u764c\u57fa\u56e0\uff0c\u6216\u6c92\u6709\u9069\u5408\u6a19\u9776\u85e5\u7269\uff0c\u75c5\u4eba\u904e\u53bb\u552f\u6709\u9078\u64c7\u5316\u7642\uff0c\u4f46\u8fd1\u5e74\u514d\u75ab\u6cbb\u7642\u51fa\u73fe\uff0c\u75c5\u4eba\u53c8\u6709\u65b0\u9078\u64c7\u3002\u514d\u75ab\u6cbb\u7642\u662f\u91dd\u5c0dPD-1\/PD-L1\u7cfb\u7d71\uff0c\u75c5\u4eba\u8981\u5148\u6aa2\u6e2c\u9ad4\u5167PD-1\/PD-L1\u6c34\u5e73\uff0c\u6c34\u5e73\u6108\u9ad8\uff0c\u514d\u75ab\u6cbb\u7642\u6548\u679c\u6108\u597d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/lungcancer-d.webp \"  type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/lungcancer-d.jpg\" class=\" sp-no-webp\" alt=\"\" decoding=\"async\"  > <\/picture><br \/>\n<span class=\"caption\">\u57fa\u56e0\u6aa2\u67e5\u2014\u2014\u78ba\u8a3a\u80ba\u764c\uff0c\u9996\u5148\u8981\u505a\u57fa\u56e0\u6aa2\u67e5\uff0c\u624d\u6c7a\u5b9a\u6cbb\u7642\u65b9\u6848\u3002\uff08natali_mis@iStockphoto\uff09<\/span><\/p>\n<p>\u300c\u4e03\u6210\u80ba\u764c\u75c5\u4eba\u7684PD-L1\u6c34\u5e73\u9ad8\u65bc1%\uff0c\u76ee\u524d\u7814\u7a76\u5efa\u8b70\uff0cPD-L1\u82e5\u9ad8\u65bc50%\uff0c\u53ef\u4ee5\u5148\u7528\u55ae\u4e00\u514d\u75ab\u6cbb\u7642\uff1b\u57281%\u81f349%\uff0c\u61c9\u540c\u6642\u63a5\u53d7\u5316\u7642\u548c\u514d\u75ab\u6cbb\u7642\uff1b\u800cPD-L1\u662f0%\u7684\u75c5\u4eba\uff0c\u5247\u9078\u64c7\u5316\u7642\u3002\u300d\u63d0\u5230\u514d\u75ab\u6cbb\u7642\uff0c\u5c31\u6703\u4ee4\u4eba\u806f\u60f3\u5230\u9ad8\u6602\u8cbb\u7528\u3002\u83ab\u8aaa\uff0c\u85e5\u8cbb\u7684\u78ba\u662f\u4e00\u500b\u96e3\u984c\uff0c\u5728\u516c\u7acb\u91ab\u9662\u63a5\u53d7\u4e00\u500b\u7642\u7a0b\u7d045\u842c\u5143\u3002\u4ed6\u671f\u671b\uff0c\u5c31\u5982\u7576\u5e74\u6a19\u9776\u85e5\u7269\u51fa\u73fe\u4e00\u6a23\uff0c\u6700\u521d\u4e0d\u5c11\u4eba\u90fd\u9a5a\u8a1d\u5409\u975e\u66ff\u5c3c\u85e5\u8cbb\u9ad8\u6602\uff0c\u4f46\u96a8\u7740\u6108\u4f86\u6108\u591a\u76f8\u95dc\u85e5\u7269\u51fa\u73fe\uff0c\u85e5\u50f9\u6703\u6162\u6162\u4e0b\u964d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u300c\u80ba\u764c\u73fe\u5728\u662f\u53ef\u6cbb\u7642\u7684\u75be\u75c5\uff0c\u671f\u671b\u4e0d\u4e45\u5c07\u4f86\uff0c\u80ba\u764c\u662f\u53ef\u6cbb\u7652\u7684\u75be\u75c5\u3002\u300d\u83ab\u6a39\u9326\u8aaa\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6587\uff1a\u912d\u5bf6\u83ef<\/p>\n<p>\u7d71\u7c4c\uff1a\u912d\u5bf6\u83ef<\/p>\n<p>\u7de8\u8f2f\uff1a\u6881\u5c0f\u73b2<\/p>\n<p>\u96fb\u90f5\uff1a<a href=\"mailto:feature@mingpao.com\">feature@mingpao.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u6b63\u5728\u5fb7\u570b\u6155\u5c3c\u9ed1\u8209\u884c\u7684\u6b50\u6d32\u816b\u7624\u5b78\u5b78\u6703\uff08ESMO 2018\uff09\uff0c\u9999\u6e2f\u4e2d\u6587\u5927\u5b78\u816b\u7624\u5b78\u7cfb\u7cfb\u4e3b\u4efb\u83ab\u6a39\u9326\u7372\u9812\u767c\u7d42\u8eab\u6210\u5c31\u734e\uff0c\u8868\u5f70\u4ed6\u662f\u5168\u7403\u7b2c\u4e00\u4eba\u628a\u751f\u7269\u6a19\u8a18\u61c9\u7528\u65bc\u80ba\u764c\u7814\u7a76\u3002 \uff08\u660e\u5831\u88fd\u5716\uff09 &nbsp; \u81ea\u5f9e\u7b2c\u4e00\u500b\u80ba\u764c\u751f\u7269\u6a19\u8a18\u300c\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u300d\uff08EGFR\uff09\u61c9\u7528\u65bc\u75c5\u4eba\u8eab\u4e0a\uff0c\u5728\u904e\u53bb\u77ed\u77ed10\u5e74\u9593\uff0c\u65b0\u7684\u751f\u7269\u6a19\u8a18\u548c\u91dd\u5c0d\u7684\u6a19\u9776\u85e5\u7269\u9678\u7e8c\u51fa\u73fe\uff0c\u52a0\u4e0a\u8fd1\u5e74\u71b1\u9580\u7684\u514d\u75ab\u6cbb\u7642\uff0c\u665a\u671f\u80ba\u764c\u6cbb\u7642\u662f\u5426\u5df2\u6bcb\u9808\u5316\u7642\uff1f\u6a19\u9776\u6cbb\u7642\u548c\u514d\u75ab\u6cbb\u7642\uff0c\u53c8\u61c9\u5982\u4f55\u9078\u64c7\uff1f &nbsp; \u672a\u6709\u6a19\u9776\u6cbb\u7642\u4e4b\u524d\uff0c\u80ba\u764c\u4e3b\u8981\u4ee5\u7d30\u80de\u5b78\u5206\u985e\uff08\u898b\u8868\u4e00\uff09\uff0c\u5316\u7642\u662f\u5c0d\u4ed8\u665a\u671f\u764c\u75c7\u552f\u4e00\u65b9\u6cd5\uff0c\u5373\u5229\u7528\u85e5\u7269\u7834\u58de\u8fc5\u901f\u751f\u9577\u7684\u764c\u7d30\u80de\uff0c\u4f46\u540c\u6642\u50b7\u53ca\u6b63\u5e38\u7d30\u80de\u3002\u5316\u7642\u75c5\u4eba\u5e73\u5747\u5b58\u6d3b\u671f\u53ea\u6709\u6578\u6708\u3002 \u83ab\u6a39\u9326\u9818\u5c0e\u7684IPASS\uff08IRESSA Pan-Asia Study\uff09\u7814\u7a76\uff0c\u662f\u80ba\u764c\u500b\u4eba\u5316\u6cbb\u7642\u7684\u91cd\u8981\u91cc\u7a0b\u7891\u3002 \uff08\u660e\u5831\u88fd\u5716\uff09 &nbsp; \u6709\u75c5\u4eba\u7528\u85e5\u903e10\u5e74 \u80ba\u764c\u53ef\u6cbb\u7642 IPASS\u662f\u4ee5\u4e9e\u6d32\u3001\u975e\u5438\u7159\u3001\u80ba\u817a\u764c\u60a3\u8005\u70ba\u7814\u7a76\u5c0d\u8c61\uff0c\u662f\u5168\u7403\u7b2c\u4e00\u500b\u7814\u7a76\u8b49\u5be6\uff0c\u5e36\u6709EGFR\u7a81\u8b8a\u7684\u80ba\u764c\u75c5\u4eba\uff0c\u4f7f\u7528\u6a19\u9776\u85e5\u5409\u975e\u66ff\u5c3c\uff08Gefitinib\uff09\uff0c\u6548\u679c\u6bd4\u5316\u7642\u7d44\u5408\u5361\u9251\uff0f\u7d2b\u6749\u9187\u512a\u52dd\u3002\u5409\u975e\u66ff\u5c3c\u56e0\u6b64\u6210\u70ba\u4e00\u7dda\u6cbb\u7642\uff0c\u6539\u5beb\u4e86\u80ba\u764c\u6cbb\u7642\u7684\u6b77\u53f2\u3002 &nbsp; \u7e7cEGFR\u4e4b\u5f8c\uff0c\u5176\u4ed6\u9a45\u52d5\u764c\u57fa\u56e0\u53ca\u76f8\u95dc\u6a19\u9776\u85e5\u7269\u9678\u7e8c\u51fa\u73fe\uff0c\u80ba\u764c\u4e0d\u518d\u662f\u55ae\u4e00\u75be\u75c5\u3001\u55ae\u4e00\u6cbb\u7642\uff08\u898b\u8868\u4e8c\uff09\u3002\u73fe\u5728\u78ba\u8a3a\u665a\u671f\u80ba\u764c\u75c5\u4eba\uff0c\u9996\u5148\u8981\u63a5\u53d7\u57fa\u56e0\u6e2c\u8a66\uff0c\u624d\u6c7a\u5b9a\u6cbb\u7642\u65b9\u6848\u3002\u516c\u7acb\u91ab\u9662\u6703\u70ba\u75c5\u4eba\u6aa2\u6e2c\u6700\u5e38\u898b\u5169\u7a2e\u9a45\u52d5\u764c\u57fa\u56e0\uff1aEGFR\u53caALK\u3002 \uff08\u660e\u5831\u88fd\u5716\uff09 &nbsp; \u4ee5\u4e9e\u6d32\u4eba\u5e38\u898b\u7684EGFR\u7a81\u8b8a\u70ba\u4f8b\uff0c\u6a19\u9776\u85e5\u7269\u5df2\u63a8\u51fa\u81f3\u7b2c\u4e09\u4ee3\uff0c\u6709\u7b2c\u4e00\u4ee3\u7684\u5409\u975e\u66ff\u5c3c\uff08Gefitinib\uff09\u548c\u5384\u6d1b\u66ff\u5c3c\uff08Erlotinib\uff09\u3001\u7b2c\u4e8c\u4ee3\u7684\u963f\u6cd5\u66ff\u5c3c\uff08Afatinib\uff09\uff0c\u4ee5\u53ca\u7b2c\u4e09\u4ee3\u7684\u5967\u5e0c\u66ff\u5c3c\uff08Osimertinib\uff09\u3002\u83ab\u6a39\u9326\u89e3\u91cb\uff0c\u7b2c\u4e8c\u4ee3\u7684\u85e5\u6548\u8f03\u7b2c\u4e00\u4ee3\u5f37\uff0c\u4f46\u76f8\u5c0d\u6bd2\u6027\u4ea6\u9ad8\uff0c\u6240\u4ee5\u6703\u5efa\u8b70\u7528\u65bc\u8f03\u5e74\u8f15\u75c5\u4eba\uff0c\u8001\u5f31\u75c5\u4eba\u5247\u7528\u7b2c\u4e00\u4ee3\u3002\u7576\u670d\u7528\u7b2c\u4e00\u4ee3\u85e5\u7269\u4e00\u6bb5\u6642\u9593\u5f8c\u51fa\u73feT790M\u57fa\u56e0\u8b8a\u7570\uff0c\u5c31\u53ef\u8f49\u7528\u7b2c\u4e09\u4ee3\u85e5\u7269\u3002\u300c\u5df2\u6709\u665a\u671f\u80ba\u764c\u75c5\u4eba\u7528\u85e5\u8d85\u904e10\u5e74\uff0c\u80ba\u764c\u5df2\u6210\u70ba\u53ef\u6cbb\u7642\u7684\u75be\u75c5\u3002\u300d &nbsp; \u53e6\u4e00\u5e38\u898b\u9a45\u52d5\u764c\u57fa\u56e0ALK\uff0c\u4ea6\u67093\u7a2e\u6a19\u9776\u85e5\uff0c\u514b\u5511\u66ff\u5c3c\uff08Crizotinib\uff09\u662f\u4e00\u7dda\u6a19\u6e96\u7642\u6cd5\uff0c\u7576\u75c5\u4eba\u51fa\u73fe\u6297\u85e5\u6027\uff0c\u91ab\u751f\u6703\u8003\u616e\u4f7f\u7528\u65b0\u85e5\u827e\u6a02\u66ff\u5c3c\uff08Alectinib\uff09\u3002\u800c\u83ab\u6a39\u9326\u9818\u5c0e\u7684\u570b\u969b\u7814\u7a76\u6bd4\u8f03\u5169\u85e5\u7528\u65bc\u4e00\u7dda\u6cbb\u7642\u7684\u529f\u6548\uff0c\u986f\u793a\u4f7f\u7528\u827e\u6a02\u66ff\u5c3c\u7684\u7121\u60e1\u5316\u5b58\u6d3b\u671f\u70ba34.8\u500b\u6708\uff0c\u8f03\u514b\u5511\u66ff\u5c3c\u768411\u500b\u6708\u9577\u3002 &nbsp; \u7372\u7d42\u8eab\u6210\u5c31\u734e\u2014\u2014\u5728\u4e0a\u5468\u4e94\u5fb7\u570b\u6155\u5c3c\u9ed1\u8209\u884c\u7684\u6b50\u6d32\u816b\u7624\u5b78\u5b78\u6703\u5e74\u6703\uff0c\u83ab\u6a39\u9326\u7372\u9812\u7d42\u8eab\u6210\u5c31\u734e\u5f8c\u767c\u8868\u6f14\u8aaa\u3002\uff08\u912d\u5bf6\u83ef\u651d\uff09 &nbsp; \u6c92\u6709\u9a45\u52d5\u764c\u57fa\u56e0 \u53ef\u7528\u514d\u75ab\u6cbb\u7642\u6216\u5316\u7642 \u82e5\u75c5\u4eba\u627e\u5230\u4e0a\u8ff0\u5169\u7a2e\u9a45\u52d5\u764c\u57fa\u56e0\uff0c\u6cbb\u7642\u9078\u64c7\u8f03\u591a\uff1b\u4f46\u81f3\u65bc\u5176\u4ed6\u4e0d\u5e38\u898b\u7684\u57fa\u56e0\uff0c\u6aa2\u6e2c\u8207\u5426\u4ecd\u7136\u5b58\u6709\u722d\u8b70\u3002\u83ab\u6a39\u9326\u89e3\u91cb\uff0c\u56e0\u70ba\u4e0d\u5e38\u898b\uff0c\u70ba\u6240\u6709\u80ba\u764c\u75c5\u4eba\u505a\u6aa2\u6e2c\u4f3c\u4e4e\u4e0d\u5408\u4e4e\u6210\u672c\u6548\u76ca\uff0c\u4ed6\u5efa\u8b70\u78ba\u8a3a\u80ba\u817a\u764c\u75c5\u4eba\uff0c\u82e5\u627e\u4e0d\u5230EGFR\u53caALK\uff0c\u624d\u8003\u616e\u6aa2\u6e2c\u5176\u4ed65\u7a2e\u4e0d\u5e38\u898b\u7684\u9a45\u52d5\u764c\u57fa\u56e0\uff1a\u5305\u62ecROS1\u3001BRAF\u3001HER2\u3001RET\u3001MET\u3002 &nbsp; \u300c\u5982\u679c\u627e\u5230EGFR\u53caALK\uff0c\u7b2c\u4e00\u7dda\u6cbb\u7642\u662f\u6a19\u9776\u85e5\uff1b\u82e5\u662f\u627e\u5230\u5176\u4ed6\u4e0d\u5e38\u898b\u7684\u57fa\u56e0\uff0c\u5c31\u6709\u4e0d\u540c\u8003\u616e\uff08\u898b\u4e3b\u5716\uff09\u3002\u300d\u83ab\u89e3\u91cb\uff0c\u76ee\u524d\u53ea\u6709\u91dd\u5c0dBRAF\u548cROS1\u7684\u6a19\u9776\u85e5\u7372FDA\u5be9\u6279\uff0c\u5176\u4ed6\u7684\u4ecd\u5728\u7814\u7a76\u5be6\u9a57\u968e\u6bb5\u3002 &nbsp; \u5982\u679c\u627e\u4e0d\u5230\u4efb\u4f55\u9a45\u52d5\u764c\u57fa\u56e0\uff0c\u6216\u6c92\u6709\u9069\u5408\u6a19\u9776\u85e5\u7269\uff0c\u75c5\u4eba\u904e\u53bb\u552f\u6709\u9078\u64c7\u5316\u7642\uff0c\u4f46\u8fd1\u5e74\u514d\u75ab\u6cbb\u7642\u51fa\u73fe\uff0c\u75c5\u4eba\u53c8\u6709\u65b0\u9078\u64c7\u3002\u514d\u75ab\u6cbb\u7642\u662f\u91dd\u5c0dPD-1\/PD-L1\u7cfb\u7d71\uff0c\u75c5\u4eba\u8981\u5148\u6aa2\u6e2c\u9ad4\u5167PD-1\/PD-L1\u6c34\u5e73\uff0c\u6c34\u5e73\u6108\u9ad8\uff0c\u514d\u75ab\u6cbb\u7642\u6548\u679c\u6108\u597d\u3002 &nbsp; \u57fa\u56e0\u6aa2\u67e5\u2014\u2014\u78ba\u8a3a\u80ba\u764c\uff0c\u9996\u5148\u8981\u505a\u57fa\u56e0\u6aa2\u67e5\uff0c\u624d\u6c7a\u5b9a\u6cbb\u7642\u65b9\u6848\u3002\uff08natali_mis@iStockphoto\uff09 \u300c\u4e03\u6210\u80ba\u764c\u75c5\u4eba\u7684PD-L1\u6c34\u5e73\u9ad8\u65bc1%\uff0c\u76ee\u524d\u7814\u7a76\u5efa\u8b70\uff0cPD-L1\u82e5\u9ad8\u65bc50%\uff0c\u53ef\u4ee5\u5148\u7528\u55ae\u4e00\u514d\u75ab\u6cbb\u7642\uff1b\u57281%\u81f349%\uff0c\u61c9\u540c\u6642\u63a5\u53d7\u5316\u7642\u548c\u514d\u75ab\u6cbb\u7642\uff1b\u800cPD-L1\u662f0%\u7684\u75c5\u4eba\uff0c\u5247\u9078\u64c7\u5316\u7642\u3002\u300d\u63d0\u5230\u514d\u75ab\u6cbb\u7642\uff0c\u5c31\u6703\u4ee4\u4eba\u806f\u60f3\u5230\u9ad8\u6602\u8cbb\u7528\u3002\u83ab\u8aaa\uff0c\u85e5\u8cbb\u7684\u78ba\u662f\u4e00\u500b\u96e3\u984c\uff0c\u5728\u516c\u7acb\u91ab\u9662\u63a5\u53d7\u4e00\u500b\u7642\u7a0b\u7d045\u842c\u5143\u3002\u4ed6\u671f\u671b\uff0c\u5c31\u5982\u7576\u5e74\u6a19\u9776\u85e5\u7269\u51fa\u73fe\u4e00\u6a23\uff0c\u6700\u521d\u4e0d\u5c11\u4eba\u90fd\u9a5a\u8a1d\u5409\u975e\u66ff\u5c3c\u85e5\u8cbb\u9ad8\u6602\uff0c\u4f46\u96a8\u7740\u6108\u4f86\u6108\u591a\u76f8\u95dc\u85e5\u7269\u51fa\u73fe\uff0c\u85e5\u50f9\u6703\u6162\u6162\u4e0b\u964d\u3002 &nbsp; \u300c\u80ba\u764c\u73fe\u5728\u662f\u53ef\u6cbb\u7642\u7684\u75be\u75c5\uff0c\u671f\u671b\u4e0d\u4e45\u5c07\u4f86\uff0c\u80ba\u764c\u662f\u53ef\u6cbb\u7652\u7684\u75be\u75c5\u3002\u300d\u83ab\u6a39\u9326\u8aaa\u3002 &nbsp; \u6587\uff1a\u912d\u5bf6\u83ef \u7d71\u7c4c\uff1a\u912d\u5bf6\u83ef \u7de8\u8f2f\uff1a\u6881\u5c0f\u73b2 \u96fb\u90f5\uff1afeature@mingpao.com<\/p>\n","protected":false},"author":5,"featured_media":15401,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_lock_modified_date":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[3,3600,3601],"tags":[2242],"class_list":["post-15400","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-3","category-3600","category-3601","tag----ipass"],"publishpress_future_action":{"enabled":false,"date":"2026-11-17 00:17:14","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/posts\/15400"}],"collection":[{"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/comments?post=15400"}],"version-history":[{"count":0,"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/posts\/15400\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/media\/15401"}],"wp:attachment":[{"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/media?parent=15400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/categories?post=15400"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/www.afterroberto.com\/wp-json\/wp\/v2\/tags?post=15400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}