{"id":15359,"date":"2018-10-15T14:56:58","date_gmt":"2018-10-15T06:56:58","guid":{"rendered":"\/\/www.afterroberto.com\/?p=15359"},"modified":"2023-10-09T18:59:55","modified_gmt":"2023-10-09T10:59:55","slug":"%e6%b2%bb%e7%99%82%e6%96%b9%e6%b3%95%ef%bc%9a%e5%8c%96%e7%99%82%e9%9b%bb%e7%99%82%e7%a7%bb%e8%87%b3%e8%a1%93%e5%89%8d-%e5%be%a9%e7%99%bc%e7%8e%87%e6%b8%9b%e5%b0%91","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e6%b2%bb%e7%99%82%e6%96%b9%e6%b3%95%ef%bc%9a%e5%8c%96%e7%99%82%e9%9b%bb%e7%99%82%e7%a7%bb%e8%87%b3%e8%a1%93%e5%89%8d-%e5%be%a9%e7%99%bc%e7%8e%87%e6%b8%9b%e5%b0%91\/","title":{"rendered":"\u6cbb\u7642\u65b9\u6cd5\uff1a\u5316\u7642\u96fb\u7642\u79fb\u81f3\u8853\u524d \u5fa9\u767c\u7387\u6e1b\u5c11"},"content":{"rendered":"

\u3010\u660e\u5831\u5c08\u8a0a\u3011\u8f14\u52a9\u5316\u7642\uff08adjuvant chemotherapy\uff09\u76ee\u6a19\u65e8\u5728\u63d0\u5347\u75c5\u4eba\u6cbb\u7652\u7387\u3002\u4ee5\u5f80\u50b3\u7d71\u7684\u8f14\u52a9\u5316\u7642\u9078\u64c7\u751a\u5c11\uff0c\u6210\u6548\u4e0d\u751a\u7406\u60f3\uff0c\u75c5\u4eba\u76845\u5e74\u5b58\u6d3b\u7387\u7d0420%\u3002\u53ca\u81f3\u6700\u8fd1\u5169\u4e09\u5e74\u65b0\u7684\u7d44\u5408\u5316\u7642Gemcitabine-Capecitabine\u53ca\u53e3\u670d\u85e5\u7269TS-ONE\u964d\u4f4e\u4e86\u75c5\u4eba\u5fa9\u767c\u7684\u6a5f\u7387\uff0c\u589e\u52a0\u75c5\u4eba5\u5e74\u5b58\u6d3b\u81f330%\u5de6\u53f3\u3002\u81f3\u65bc\u8f14\u52a9\u96fb\u7642\uff08adjuvant radiotherapy\uff09\uff0c\u5247\u65e8\u5728\u6e1b\u5c11\u75c5\u4eba\u5c40\u90e8\u5fa9\u767c\u98a8\u96aa\uff0c\u591a\u61c9\u7528\u65bc\u624b\u8853\u5f8c\u5c40\u90e8\u4ecd\u6b98\u9918\u764c\u7d30\u80de\u7684\u75c5\u4eba\u8eab\u4e0a\u3002<\/p>\n

\u5b58\u6d3b\u4e2d\u4f4d\u6578\u5927\u589e\u81f354\u6708<\/p>\n

\u65bc2018\u7f8e\u570b\u81e8\u7240\u816b\u7624\u5b78\u5927\u6703\uff08ASCO\uff09\uff0c\u6709\u5169\u500b\u95dc\u65bc\u80f0\u81df\u764c\u8f14\u52a9\u6cbb\u7642\u7684\u91cd\u8981\u767c\u5e03\uff1a<\/p>\n

1. \u8f14\u52a9\u5316\u7642\u7d44\u5408FOLFIRINOX<\/p>\n

FOLFIRINOX\u662f\u4e00\u7a2e\u5305\u542b3\u96bb\u85e5\uff085-FU, Irinotecan, Oxaliplatin\uff09\u7684\u5316\u7642\u7d44\u5408\uff0c\u5c6c\u665a\u671f\u80f0\u81df\u764c\u75c5\u4eba\u5176\u4e2d\u4e00\u7a2e\u6a19\u6e96\u6cbb\u7642\u3002\u6700\u65b0\u7684\u7814\u7a76\u5c07FOLFIRINOX\u6bd4\u5c0d\u50b3\u7d71\u5316\u7642Gemcitabine\uff0c\u65bc\u7d04500\u500b\u75c5\u4eba\u4e2d\u4f5c\u6bd4\u5c0d\uff0c\u75c5\u4eba\u63a5\u53d7FOLFIRINOX\u7684\u5b58\u6d3b\u4e2d\u4f4d\u6578\uff08median overall survival\uff09\u753135\u500b\u6708\u5927\u5e45\u63d0\u5347\u81f354\u500b\u6708\uff0c\u7d50\u679c\u76f8\u7576\u9a5a\u4eba\uff0c\u76f8\u4fe1\u6b64\u7d44\u5408\u52e2\u5c07\u6210\u70ba\u80f0\u81df\u764c\u8853\u5f8c\u7684\u6a19\u6e96\u6cbb\u7642\u3002<\/p>\n

2. \u8f14\u52a9\u6cbb\u7642\u63a8\u81f3\u624b\u8853\u524d<\/p>\n

\u4ee5\u5f80\u80f0\u81df\u764c\u75c5\u4eba\u591a\u662f\u5148\u4ee5\u624b\u8853\u5207\u9664\u816b\u7624\u5f8c\u63a5\u53d7\u5316\u7642\uff0c\u4f46\u7531\u65bc\u5fae\u64f4\u6563\u751a\u666e\u904d\uff0c\u56e0\u6b64\u5fa9\u767c\u6a5f\u7387\u4f9d\u7136\u504f\u9ad8\u3002\u5728\u6700\u65b0\u7684PREOPANC\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u54e1\u5c07\u75c5\u4eba\u5206\u70ba\u5169\u7d44\uff0c\u4e00\u7d44\u6309\u50b3\u7d71\u5148\u63a5\u53d7\u624b\u8853\u5f8c\u5316\u7642\uff0c\u53e6\u4e00\u5be6\u9a57\u7d44\u5247\u5148\u63a5\u53d7\u5316\u7642\u53ca\u96fb\u7642\u5f8c\u65bd\u624b\u8853\u3002\u7814\u7a76\u7d50\u679c\u767c\u73fe\u5148\u5316\u7642\u53ca\u96fb\u7642\u5f8c\u505a\u624b\u8853\u7684\u75c5\u4eba\u5fa9\u767c\u6a5f\u7387\u6e1b\u5c11\uff0c\u800c\u751f\u5b58\u7387\u4ea6\u6bd4\u50b3\u7d71\u7642\u6cd5\u66f4\u512a\u52dd\u3002<\/p>\n

\u56e0\u6b64\uff0c\u76f8\u4fe1\u5728\u4e0d\u4e45\u7684\u5c07\u4f86\uff0c\u7642\u6548\u66f4\u4f73\u4f46\u526f\u4f5c\u7528\u7a0d\u589e\u7684\u7d44\u5408\u5f0f\u5316\u7642\uff08FOLFIRINOX\u7b49\uff09\u52e2\u5c07\u6210\u70ba\u80f0\u81df\u764c\u8f14\u52a9\u6cbb\u7642\u7684\u5168\u65b0\u6a19\u6e96\uff1b\u800c\u8f14\u52a9\u6cbb\u7642\u7684\u9ec3\u91d1\u6642\u9593\u5c07\u6703\u7531\u624b\u8853\u5f8c\u63a8\u524d\u81f3\u624b\u8853\u524d\u3002<\/p>\n

\u4e0a\u6587\u500b\u6848\u4e2d\u7684\u9673\u5148\u751f\u63a5\u53d76\u500b\u6708\u7684\u5316\u7642\u53ca5\u661f\u671f\u7684\u96fb\u7642\u5f8c\uff0c\u73fe\u5df2\u5b8c\u5168\u5eb7\u5fa9\uff0c\u6700\u8fd1\u4e00\u6b21\u6b63\u96fb\u5b50\u6383\u63cf\u986f\u793a\u6c92\u6709\u4efb\u4f55\u5fa9\u767c\u8ff9\u8c61\u3002\u7531\u6b64\u53ef\u898b\uff0c\u96d6\u7136\u80f0\u81df\u764c\u662f\u764c\u75c7\u6bba\u624b\u4e2d\u7684\u6bba\u624b\uff0c\u4f46\u53ea\u8981\u53ca\u6642\u767c\u73fe\uff0c\u4e26\u7531\u6709\u7d93\u9a57\u7684\u5916\u79d1\u91ab\u751f\u5c07\u816b\u7624\u5207\u9664\uff0c\u518d\u914d\u5408\u9069\u7576\u7684\u8f14\u52a9\u6cbb\u7642\uff0c\u6839\u6cbb\u4ea6\u975e\u7d55\u4e0d\u53ef\u80fd\uff1b\u671f\u671b\u6700\u65b0\u7684\u7814\u7a76\u7d50\u679c\u80fd\u76e1\u5feb\u61c9\u7528\u65bc\u66f4\u591a\u81e8\u7240\u75c5\u4eba\u4e0a\uff0c\u8b93\u66f4\u591a\u80f0\u81df\u764c\u75c5\u4eba\u5f97\u5230\u6839\u6cbb\u7684\u6a5f\u6703\u3002<\/p>\n

\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/health20181015a1.jpg\u96fb\u7642\u7bc4\u570d\u2014\u2014\u96fb\u7642\u7bc4\u570d\u91dd\u5c0d\u624b\u8853\u5f8c\u9ad8\u5371\u5fa9\u767c\u7684\u4f4d\u7f6e\u3002\uff08\u4f5c\u8005\u63d0\u4f9b\uff09;<\/inline><\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u660e\u5831\u5c08\u8a0a\u3011\u8f14\u52a9\u5316\u7642\uff08adjuvant chemotherapy\uff09\u76ee\u6a19\u65e8\u5728\u63d0\u5347\u75c5\u4eba\u6cbb\u7652\u7387\u3002\u4ee5\u5f80\u50b3\u7d71\u7684\u8f14\u52a9\u5316\u7642\u9078\u64c7\u751a\u5c11\uff0c\u6210\u6548\u4e0d\u751a\u7406\u60f3\uff0c\u75c5\u4eba\u76845\u5e74\u5b58\u6d3b\u7387\u7d0420%\u3002\u53ca\u81f3\u6700\u8fd1\u5169\u4e09\u5e74\u65b0\u7684\u7d44\u5408\u5316\u7642Gemcitabine-Capecitabine\u53ca\u53e3\u670d\u85e5\u7269TS-ONE\u964d\u4f4e\u4e86\u75c5\u4eba\u5fa9\u767c\u7684\u6a5f\u7387\uff0c\u589e\u52a0\u75c5\u4eba5\u5e74\u5b58\u6d3b\u81f330%\u5de6\u53f3\u3002\u81f3\u65bc\u8f14\u52a9\u96fb\u7642\uff08adjuvant radiotherapy\uff09\uff0c\u5247\u65e8\u5728\u6e1b\u5c11\u75c5\u4eba\u5c40\u90e8\u5fa9\u767c\u98a8\u96aa\uff0c\u591a\u61c9\u7528\u65bc\u624b\u8853\u5f8c\u5c40\u90e8\u4ecd\u6b98\u9918\u764c\u7d30\u80de\u7684\u75c5\u4eba\u8eab\u4e0a\u3002 \u5b58\u6d3b\u4e2d\u4f4d\u6578\u5927\u589e\u81f354\u6708 \u65bc2018\u7f8e\u570b\u81e8\u7240\u816b\u7624\u5b78\u5927\u6703\uff08ASCO\uff09\uff0c\u6709\u5169\u500b\u95dc\u65bc\u80f0\u81df\u764c\u8f14\u52a9\u6cbb\u7642\u7684\u91cd\u8981\u767c\u5e03\uff1a 1. \u8f14\u52a9\u5316\u7642\u7d44\u5408FOLFIRINOX FOLFIRINOX\u662f\u4e00\u7a2e\u5305\u542b3\u96bb\u85e5\uff085-FU, Irinotecan, Oxaliplatin\uff09\u7684\u5316\u7642\u7d44\u5408\uff0c\u5c6c\u665a\u671f\u80f0\u81df\u764c\u75c5\u4eba\u5176\u4e2d\u4e00\u7a2e\u6a19\u6e96\u6cbb\u7642\u3002\u6700\u65b0\u7684\u7814\u7a76\u5c07FOLFIRINOX\u6bd4\u5c0d\u50b3\u7d71\u5316\u7642Gemcitabine\uff0c\u65bc\u7d04500\u500b\u75c5\u4eba\u4e2d\u4f5c\u6bd4\u5c0d\uff0c\u75c5\u4eba\u63a5\u53d7FOLFIRINOX\u7684\u5b58\u6d3b\u4e2d\u4f4d\u6578\uff08median overall survival\uff09\u753135\u500b\u6708\u5927\u5e45\u63d0\u5347\u81f354\u500b\u6708\uff0c\u7d50\u679c\u76f8\u7576\u9a5a\u4eba\uff0c\u76f8\u4fe1\u6b64\u7d44\u5408\u52e2\u5c07\u6210\u70ba\u80f0\u81df\u764c\u8853\u5f8c\u7684\u6a19\u6e96\u6cbb\u7642\u3002 2. \u8f14\u52a9\u6cbb\u7642\u63a8\u81f3\u624b\u8853\u524d \u4ee5\u5f80\u80f0\u81df\u764c\u75c5\u4eba\u591a\u662f\u5148\u4ee5\u624b\u8853\u5207\u9664\u816b\u7624\u5f8c\u63a5\u53d7\u5316\u7642\uff0c\u4f46\u7531\u65bc\u5fae\u64f4\u6563\u751a\u666e\u904d\uff0c\u56e0\u6b64\u5fa9\u767c\u6a5f\u7387\u4f9d\u7136\u504f\u9ad8\u3002\u5728\u6700\u65b0\u7684PREOPANC\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u54e1\u5c07\u75c5\u4eba\u5206\u70ba\u5169\u7d44\uff0c\u4e00\u7d44\u6309\u50b3\u7d71\u5148\u63a5\u53d7\u624b\u8853\u5f8c\u5316\u7642\uff0c\u53e6\u4e00\u5be6\u9a57\u7d44\u5247\u5148\u63a5\u53d7\u5316\u7642\u53ca\u96fb\u7642\u5f8c\u65bd\u624b\u8853\u3002\u7814\u7a76\u7d50\u679c\u767c\u73fe\u5148\u5316\u7642\u53ca\u96fb\u7642\u5f8c\u505a\u624b\u8853\u7684\u75c5\u4eba\u5fa9\u767c\u6a5f\u7387\u6e1b\u5c11\uff0c\u800c\u751f\u5b58\u7387\u4ea6\u6bd4\u50b3\u7d71\u7642\u6cd5\u66f4\u512a\u52dd\u3002 \u56e0\u6b64\uff0c\u76f8\u4fe1\u5728\u4e0d\u4e45\u7684\u5c07\u4f86\uff0c\u7642\u6548\u66f4\u4f73\u4f46\u526f\u4f5c\u7528\u7a0d\u589e\u7684\u7d44\u5408\u5f0f\u5316\u7642\uff08FOLFIRINOX\u7b49\uff09\u52e2\u5c07\u6210\u70ba\u80f0\u81df\u764c\u8f14\u52a9\u6cbb\u7642\u7684\u5168\u65b0\u6a19\u6e96\uff1b\u800c\u8f14\u52a9\u6cbb\u7642\u7684\u9ec3\u91d1\u6642\u9593\u5c07\u6703\u7531\u624b\u8853\u5f8c\u63a8\u524d\u81f3\u624b\u8853\u524d\u3002 \u4e0a\u6587\u500b\u6848\u4e2d\u7684\u9673\u5148\u751f\u63a5\u53d76\u500b\u6708\u7684\u5316\u7642\u53ca5\u661f\u671f\u7684\u96fb\u7642\u5f8c\uff0c\u73fe\u5df2\u5b8c\u5168\u5eb7\u5fa9\uff0c\u6700\u8fd1\u4e00\u6b21\u6b63\u96fb\u5b50\u6383\u63cf\u986f\u793a\u6c92\u6709\u4efb\u4f55\u5fa9\u767c\u8ff9\u8c61\u3002\u7531\u6b64\u53ef\u898b\uff0c\u96d6\u7136\u80f0\u81df\u764c\u662f\u764c\u75c7\u6bba\u624b\u4e2d\u7684\u6bba\u624b\uff0c\u4f46\u53ea\u8981\u53ca\u6642\u767c\u73fe\uff0c\u4e26\u7531\u6709\u7d93\u9a57\u7684\u5916\u79d1\u91ab\u751f\u5c07\u816b\u7624\u5207\u9664\uff0c\u518d\u914d\u5408\u9069\u7576\u7684\u8f14\u52a9\u6cbb\u7642\uff0c\u6839\u6cbb\u4ea6\u975e\u7d55\u4e0d\u53ef\u80fd\uff1b\u671f\u671b\u6700\u65b0\u7684\u7814\u7a76\u7d50\u679c\u80fd\u76e1\u5feb\u61c9\u7528\u65bc\u66f4\u591a\u81e8\u7240\u75c5\u4eba\u4e0a\uff0c\u8b93\u66f4\u591a\u80f0\u81df\u764c\u75c5\u4eba\u5f97\u5230\u6839\u6cbb\u7684\u6a5f\u6703\u3002 \/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/health20181015a1.jpg\u96fb\u7642\u7bc4\u570d\u2014\u2014\u96fb\u7642\u7bc4\u570d\u91dd\u5c0d\u624b\u8853\u5f8c\u9ad8\u5371\u5fa9\u767c\u7684\u4f4d\u7f6e\u3002\uff08\u4f5c\u8005\u63d0\u4f9b\uff09;<\/p>\n","protected":false},"author":5,"featured_media":15360,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"rank_math_lock_modified_date":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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