{"id":15261,"date":"2018-10-08T12:09:20","date_gmt":"2018-10-08T04:09:20","guid":{"rendered":"\/\/www.afterroberto.com\/?p=15261"},"modified":"2019-06-20T18:47:37","modified_gmt":"2019-06-20T10:47:37","slug":"%e9%86%ab%e8%a8%80%e6%9c%89%e7%90%86%ef%bc%9a%e6%aa%a2%e6%9f%a5%e9%bb%9e%e6%8a%91%e5%88%b6%e5%8a%91-%e6%8a%97%e7%99%8c%e6%96%b0%e4%b8%80%e9%a0%81","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e9%86%ab%e8%a8%80%e6%9c%89%e7%90%86%ef%bc%9a%e6%aa%a2%e6%9f%a5%e9%bb%9e%e6%8a%91%e5%88%b6%e5%8a%91-%e6%8a%97%e7%99%8c%e6%96%b0%e4%b8%80%e9%a0%81\/","title":{"rendered":"\u91ab\u8a00\u6709\u7406\uff1a\u6aa2\u67e5\u9ede\u6291\u5236\u5291 \u6297\u764c\u65b0\u4e00\u9801"},"content":{"rendered":"<p>\u7f8e\u570b\u7684Dr James P. Allison\u53ca\u65e5\u672c\u7684Dr Tasuku Honjo\u540c\u7372\u98122018\u5e74\u7684\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\uff0c\u5169\u4f4d\u5091\u51fa\u300c\u514d\u75ab\u5b78\u5bb6\u300d\uff08Immunologists\uff09\u7684\u7814\u7a76\u6210\u679c\uff0c\u70ba\u65b0\u4e00\u4ee3\u300c\u6297\u764c\u514d\u75ab\u6cbb\u7642\u300d\uff08Anti-cancer immunotherapy\uff09\u5960\u4e0b\u57fa\u77f3\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><picture><source srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/1d905652cd422fdb708420720da2274d.webp \"  type=\"image\/webp\"><img src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2018\/10\/1d905652cd422fdb708420720da2274d.jpg\" class=\" sp-no-webp\" alt=\"\" decoding=\"async\"  > <\/picture><br \/>\n<span class=\"caption\">\u8afe\u734e\u96d9\u5091\u2014\u20142018\u5e74\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u5f97\u4e3bDr Tasuku Honjo\uff08\u5de6\uff09\u53caDr James P. Allison\uff08\u53f3\uff09\uff0c\u4ed6\u5011\u7814\u7a76\u7684\u6aa2\u67e5\u9ede\u86cb\u767d\uff0c\u70ba\u6297\u764c\u514d\u75ab\u6cbb\u7642\u5960\u4e0b\u57fa\u77f3\u3002\uff08\u8cc7\u6599\u5716\u7247\uff09<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u300c\u6dcb\u5df4\u7d30\u80de\u300d\uff08Lymphocytes\uff09\u4e43\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u4e3b\u529b\u9aa8\u5e79\uff0c\u6709B\u7d30\u80de\u3001T\u7d30\u80de\u53caNK\u7d30\u80de\uff0c\u53ef\u5c0d\u4ed8\u5404\u7a2e\u5165\u4fb5\u7570\u7269\uff0c\u5305\u62ec\u7d30\u83cc\u75c5\u6bd2\uff0c\u4eba\u9ad4\u5167\u6709\u6a5f\u5236\u907f\u514d\u300c\u6dcb\u5df4\u7d30\u80de\u300d\u653b\u64ca\u5c6c\u65bc\u81ea\u5df1\u7684\u6b63\u5e38\u7d30\u80de\u3002<\/p>\n<p>\u5169\u4f4d\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u5f97\u4e3b\u5206\u5225\u767c\u73fe\u300c\u6dcb\u5df4\u7d30\u80de\u300d\u8868\u9762\u6709\u5169\u7a2e\u300c\u6aa2\u67e5\u9ede\u86cb\u767d\u300d\uff08Checkpoint protein\uff09\uff1aPD-1\u53caCTLA-4\uff0c\u53ef\u4fdd\u8b77\u81ea\u8eab\u6b63\u5e38\u7d30\u80de\uff0c\u9632\u6b62\u300c\u81ea\u9ad4\u514d\u75ab\u7cfb\u7d71\u75be\u75c5\u300d\uff08Autoimmune diseases\uff09\u51fa\u73fe\u3002<\/p>\n<p>\u764c\u75c7\u60a3\u8005\u9ad4\u5167\u7684\u300c\u764c\u7d30\u80de\u300d\u540c\u6a23\u53d7\u5230\u300c\u6aa2\u67e5\u9ede\u86cb\u767d\u300d\u7684\u4fdd\u8b77\uff0c\u514d\u53d7\u81ea\u8eab\u300c\u6dcb\u5df4\u7d30\u80de\u300d\u7684\u653b\u64ca\u3002\u300c\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u300d\uff08Checkpoint inhibitors\uff09\u904f\u5236\u300c\u6aa2\u67e5\u9ede\u86cb\u767d\u300d\uff0c\u4ee4\u81ea\u9ad4\u6dcb\u5df4\u7d30\u80de\u6062\u5fa9\u80fd\u529b\uff0c\u53ef\u653b\u64ca\u53ca\u6d88\u6ec5\u9ad4\u5167\u764c\u7d30\u80de\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u904f\u5236\u764c\u7d30\u80de\u300c\u4fdd\u8b77\u7f69\u300d<\/h2>\n<p>\u81e8\u7240\u7814\u7a76\u986f\u793a\u591a\u7a2e\u300c\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u300d\u6709\u986f\u8457\u6297\u764c\u4f5c\u7528\uff0c\u5305\u62ec\u6291\u5236\u300c\u6dcb\u5df4\u7d30\u80de\u300d\u8868\u9762PD-1\u86cb\u767d\u7684\u300c\u6297\u9ad4\u300dNivolumab\u53caPembrolizumab\uff1b\u9084\u6709\u6291\u5236\u300c\u764c\u7d30\u80de\u300d\u8868\u9762PD-1\u300c\u914d\u9ad4\u300d\uff08Ligands\uff09\u7684PD-L1\u6297\u9ad4Atezolizumab\u3001Avelumab\u53caDurvalumab\uff0c\u53ef\u7528\u65bc\u6cbb\u7642\u300c\u9ed1\u7d20\u7624\u300d\uff08Melanoma\uff09\u3001\u300c\u80ba\u764c\u300d\uff08Lung cancer\uff09\u53ca\u300c\u6dcb\u5df4\u764c\u300d\uff08Lymphoma\uff09\uff0c\u5c24\u5176\u300c\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u300d\uff08Non small cell lung cancer\uff09\u53ca\u300c\u4f55\u5091\u91d1\u6c0f\u6dcb\u5df4\u764c\u300d\uff08Hodgkin lymphoma\uff09\u3002\u6b64\u5916\uff0c\u6709\u6291\u5236\u53e6\u4e00\u7a2e\u300c\u6aa2\u67e5\u9ede\u86cb\u767d\u300dCTLA-4\u7684\u6297\u9ad4Ipilimumab\uff0c\u540c\u6a23\u6709\u6297\u764c\u4f5c\u7528\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u6cbb\u7642\u80ba\u764c\u3001\u6dcb\u5df4\u764c<\/h2>\n<p>\u9084\u6709\u5176\u4ed6\u300c\u6aa2\u67e5\u9ede\u86cb\u767d\u300d\u53ef\u4f5c\u6297\u764c\u76ee\u6a19\uff0c\u5305\u62ecBTLA\u3001VTISA\u3001Tim-3\u53caLAG-3\uff1b\u6291\u5236\u9019\u4e9b\u300c\u6aa2\u67e5\u9ede\u86cb\u767d\u300d\u7684\u6297\u9ad4\uff0c\u7686\u5df2\u9032\u5165\u81e8\u7240\u8a66\u9a57\u968e\u6bb5\u3002\u671f\u671b\u65b0\u4e00\u4ee3\u7684\u300c\u6aa2\u67e5\u9ede\u6291\u5236\u5291\u300d\uff0c\u53ef\u70ba\u6297\u764c\u6cbb\u7642\u6253\u958b\u65b0\u7684\u4e00\u9801\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6587\uff1a\u6881\u61b2\u5b6b\uff08\u8840\u6db2\u53ca\u8840\u6db2\u816b\u7624\u79d1\u5c08\u79d1\u91ab\u751f\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u7684Dr James P. Allison\u53ca\u65e5\u672c\u7684Dr Tasuku Honjo\u540c\u7372\u98122018\u5e74\u7684\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\uff0c\u5169\u4f4d\u5091\u51fa\u300c\u514d\u75ab\u5b78\u5bb6\u300d\uff08Immunologists\uff09\u7684\u7814\u7a76\u6210\u679c\uff0c\u70ba\u65b0\u4e00\u4ee3\u300c\u6297\u764c\u514d\u75ab\u6cbb\u7642\u300d\uff08Anti-cancer immunotherapy\uff09\u5960\u4e0b\u57fa\u77f3\u3002 &nbsp; \u8afe\u734e\u96d9\u5091\u2014\u20142018\u5e74\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u5f97\u4e3bDr Tasuku Honjo\uff08\u5de6\uff09\u53caDr James P. Allison\uff08\u53f3\uff09\uff0c\u4ed6\u5011\u7814\u7a76\u7684\u6aa2\u67e5\u9ede\u86cb\u767d\uff0c\u70ba\u6297\u764c\u514d\u75ab\u6cbb\u7642\u5960\u4e0b\u57fa\u77f3\u3002\uff08\u8cc7\u6599\u5716\u7247\uff09 &nbsp; \u300c\u6dcb\u5df4\u7d30\u80de\u300d\uff08Lymphocytes\uff09\u4e43\u4eba\u9ad4\u514d\u75ab\u7cfb\u7d71\u7684\u4e3b\u529b\u9aa8\u5e79\uff0c\u6709B\u7d30\u80de\u3001T\u7d30\u80de\u53caNK\u7d30\u80de\uff0c\u53ef\u5c0d\u4ed8\u5404\u7a2e\u5165\u4fb5\u7570\u7269\uff0c\u5305\u62ec\u7d30\u83cc\u75c5\u6bd2\uff0c\u4eba\u9ad4\u5167\u6709\u6a5f\u5236\u907f\u514d\u300c\u6dcb\u5df4\u7d30\u80de\u300d\u653b\u64ca\u5c6c\u65bc\u81ea\u5df1\u7684\u6b63\u5e38\u7d30\u80de\u3002 \u5169\u4f4d\u8afe\u8c9d\u723e\u751f\u7406\u5b78\u6216\u91ab\u5b78\u734e\u5f97\u4e3b\u5206\u5225\u767c\u73fe\u300c\u6dcb\u5df4\u7d30\u80de\u300d\u8868\u9762\u6709\u5169\u7a2e\u300c\u6aa2\u67e5\u9ede\u86cb\u767d\u300d\uff08Checkpoint 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