{"id":11062,"date":"2017-11-27T12:04:34","date_gmt":"2017-11-27T04:04:34","guid":{"rendered":"\/\/www.afterroberto.com\/?p=11062"},"modified":"2019-12-09T16:43:55","modified_gmt":"2019-12-09T08:43:55","slug":"%e7%94%a8%e5%8d%b5%e5%b7%a2%e7%99%8c%e8%97%a5%e9%86%ab%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%ef%bc%9f-ngs%e9%85%8d%e5%b0%8d-%e5%b0%8b%e6%89%be%e9%9a%b1%e8%97%8f%e6%95%91%e6%98%9f","status":"publish","type":"post","link":"\/\/www.afterroberto.com\/%e7%94%a8%e5%8d%b5%e5%b7%a2%e7%99%8c%e8%97%a5%e9%86%ab%e5%89%8d%e5%88%97%e8%85%ba%e7%99%8c%ef%bc%9f-ngs%e9%85%8d%e5%b0%8d-%e5%b0%8b%e6%89%be%e9%9a%b1%e8%97%8f%e6%95%91%e6%98%9f\/","title":{"rendered":"\u7528\u5375\u5de2\u764c\u85e5\u91ab\u524d\u5217\u817a\u764c\uff1f NGS\u914d\u5c0d \u5c0b\u627e\u96b1\u85cf\u6551\u661f"},"content":{"rendered":"<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u65b0\u7642\u6cd5\uff1a\u6b21\u4e16\u4ee3\u5b9a\u5e8f Next generation sequencing\uff0cNGS<\/p>\n<p>81\u6b72\u674e\u5148\u751f\u7684\u524d\u5217\u817a\u764c\u8f49\u79fb\uff0c\u4eca\u5e74\u4e8c\u6708\u56e0\u982d\u75db\u982d\u6688\u5165\u9662\uff0c\u767c\u73fe\u8166\u90e8\u6709\u5341\u591a\u500b\u816b\u7624\u3002\u63a5\u53d7\u96fb\u7642\u3001\u8377\u723e\u8499\u6cbb\u7642\u5f8c\u5fb5\u72c0\u660e\u986f\u6e1b\u5c11\uff0c\u4f46\u4e09\u500b\u6708\u5f8c\uff0c\u8166\u90e8\u65b0\u51fa\u73fe\u8fd120\u500b\u816b\u7624\u3002<\/p>\n<p>\u816b\u7624\u5982\u6b64\u5147\u60e1\uff0c\u5341\u5206\u7f55\u898b\u3002\u9762\u5c0d\u9ad8\u9f61\u53ca\u6709\u5176\u4ed6\u6162\u6027\u75c5\u7684\u674e\u5148\u751f\uff0c\u91ab\u7642\u5718\u968a\u53ea\u80fd\u5750\u4ee5\u5f85\u6583\uff1f\u57fa\u56e0\u6aa2\u6e2c\u3001\u6a19\u9776\u85e5\u7269\u5982\u4f55\u5e6b\u52a9\u674e\u5148\u751f\u5b89\u5ea682\u6b72\u751f\u65e5\uff1f<\/p>\n<p>&nbsp;<\/p>\n<h2>\u500b\u6848<\/h2>\n<p>\u8001\u7fc1\u524d\u5217\u817a\u764c\u4e0a\u8166 \u6cbb\u7642\u56f0\u96e3<\/p>\n<p>\u674e\u5148\u751f\u53bb\u5e74\u56e0\u80ba\u708e\u4f4f\u9662\uff0c\u5176\u9593\u767c\u73fe\u524d\u5217\u817a\u764c\u6307\u6578\uff08PSA\uff09\u7a0d\u9ad8\u3002\u6642\u5e7481\u6b72\u7684\u4ed6\u6709\u6162\u6027\u80ba\u6c23\u816b\uff0c\u4e0d\u5e0c\u671b\u505a\u524d\u5217\u817a\u7a7f\u523a\u6aa2\u67e5\uff0c\u4fbf\u6c7a\u5b9a\u4ee5\u4fdd\u5b88\u6cbb\u7642\uff0c\u89c0\u5bdfPSA\u7684\u8d70\u52e2\u3002<\/p>\n<p>\u6578\u6708\u904e\u53bb\uff0c\u674e\u5148\u751f\u8eab\u9ad4\u60c5\u51b5\u5c1a\u7b97\u7a69\u5b9a\uff0cPSA\u6307\u6578\u53ea\u662f\u4e0a\u5347\u4e86\u5c11\u8a31\u3002\u4f46\u4eca\u5e742\u6708\u674e\u5148\u751f\u7a81\u7136\u89ba\u5f97\u982d\u6688\u982d\u75db\uff0c\u6b65\u5c65\u4e0d\u7a69\u3002\u5165\u9662\u6aa2\u67e5\u7adf\u767c\u73fe\u8166\u90e8\u6709\u5341\u591a\u500b\u816b\u7624\uff0c\u6700\u5927\u7684\u4e00\u500b\u76f4\u5f91\u90543.5\u5398\u7c73\uff0c\u58d3\u8feb\u8166\u5e79\u795e\u7d93\uff08\u5716\u4e00\uff09\u3002\u5168\u8eab\u6b63\u96fb\u5b50\u6383\u63cf\u767c\u73fe\u524d\u5217\u817a\u548c\u76c6\u8154\u6dcb\u5df4\u70ba\u53ef\u7591\u7684\u816b\u7624\u6e90\u982d\u3002<\/p>\n<figure id=\"attachment_22791\" aria-describedby=\"caption-attachment-22791\" style=\"width: 189px\" class=\"wp-caption alignnone\"><a href=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befb0b44af1d4e6cb17c55fa0cefb8af-1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-22791\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befb0b44af1d4e6cb17c55fa0cefb8af-1.jpg\" alt=\"\" width=\"189\" height=\"824\" title=\"\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befb0b44af1d4e6cb17c55fa0cefb8af-1.jpg 189w, \/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befb0b44af1d4e6cb17c55fa0cefb8af-1-69x300.jpg 69w\" sizes=\"(max-width: 189px) 100vw, 189px\" \/><\/a><figcaption id=\"caption-attachment-22791\" class=\"wp-caption-text\">\uff08\u5716\uff1a\u53d7\u8a2a\u8005\u63d0\u4f9b\uff09<\/figcaption><\/figure>\n<p>\u674e\u5148\u751f\u75c5\u60c5\u5341\u5206\u5371\u6025\u3002\u8166\u5916\u79d1\u548c\u9ebb\u9189\u79d1\u8a8d\u70ba\u75c5\u4eba\u80ba\u529f\u80fd\u4e0d\u597d\uff0c\u4e14\u8166\u90e8\u8840\u7ba1\u6709\u56b4\u91cd\u786c\u5316\uff0c\u505a\u958b\u8166\u624b\u8853\u98a8\u96aa\u904e\u9ad8\u3002\u75c5\u4eba\u4e5f\u4e0d\u5e0c\u671b\u5192\u592a\u5927\u98a8\u96aa\u3002\u5718\u968a\u70ba\u5148\u751f\u5b89\u6392\u4e86\u7acb\u9ad4\u5b9a\u5411\u653e\u5c04\u624b\u8853\uff08stereotactic radiosurgery\uff0cSRS\uff09\uff0c\u4ee5\u9ad8\u6e96\u78ba\u5ea6\u53ca\u9ad8\u5291\u91cf\u7684X\u5149\uff0c\u91dd\u5c0d\u8166\u90e814\u500b\u816b\u7624\u9032\u884c\u653e\u5c04\u6cbb\u7642\u3002<\/p>\n<p>SRS\u5f8c\uff0c\u674e\u5148\u751f\u7684\u8166\u90e8\u75c5\u5fb5\u660e\u986f\u6e1b\u8f15\uff0c\u5718\u968a\u4ea6\u70ba\u674e\u5148\u751f\u5b89\u6392\u8377\u723e\u8499\u6cbb\u7642\uff0c\u524d\u5217\u817a\u764c\u6307\u6578\u9010\u6f38\u4e0b\u964d\u3002SRS\u5f8c\u4e00\u500b\u6708\u7684\u78c1\u529b\u5171\u632f\u767c\u73fe\u8166\u90e8\u816b\u7624\u5168\u90e8\u90fd\u660e\u986f\u7e2e\u5c0f\u4e86\u3002<\/p>\n<p>\u53ef\u662f\uff0cSRS\u5f8c\u4e09\u500b\u6708\uff0c\u78c1\u529b\u5171\u632f\u518d\u6b21\u767c\u73fe\u8166\u90e8\u51fa\u73fe\u4e86\u8fd120\u500b\u65b0\u7684\u816b\u7624\uff08\u5716\u4e8c\uff09\u3002\u5168\u8eab\u6b63\u96fb\u5b50\u6383\u63cf\u4e5f\u767c\u73fe\u76c6\u8154\u548c\u8179\u90e8\u7684\u816b\u7624\u6578\u76ee\u589e\u52a0\u4e86\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u9ad8\u9f61\u517c\u6162\u6027\u75c5\u60a3 \u5316\u7642\u98a8\u96aa\u5927<\/h2>\n<p>\u8377\u723e\u8499\u6cbb\u7642\u5c0d\u524d\u5217\u817a\u764c\u7684\u63a7\u5236\uff0c\u901a\u5e38\u90fd\u8d85\u904e6\u81f312\u500b\u6708\uff0c\u674e\u5148\u751f\u75c5\u60c5\u57283\u500b\u6708\u5167\u6025\u901f\u60e1\u5316\u7740\u5be6\u7f55\u898b\u3002\u82e5\u8ddf\u96a8\u50b3\u7d71\u7684\u524d\u5217\u817a\u764c\u6cbb\u7642\u6307\u5f15\uff0c\u674e\u5148\u751f\u53ef\u80fd\u8981\u8003\u616e\u5316\u5b78\u6cbb\u7642\uff0c\u4f46\u4ee5\u903e80\u6b72\u9ad8\u9f61\u4e14\u8eab\u9ad4\u6709\u6162\u6027\u75be\u75c5\u7684\u8003\u616e\u4e0b\uff0c\u5316\u7642\u98a8\u96aa\u5be6\u5728\u592a\u9ad8\uff0c\u7642\u6548\u4e0d\u592a\u660e\u986f\uff0c\u800c\u4e14\u85e5\u7269\u672a\u5fc5\u80fd\u9032\u5165\u8166\u90e8\u63a7\u5236\u816b\u7624\u64f4\u6563\u3002<\/p>\n<figure id=\"attachment_22790\" aria-describedby=\"caption-attachment-22790\" style=\"width: 448px\" class=\"wp-caption alignnone\"><a href=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befb1860f51f6d3474fba550ae3d20e3-1.jpg\"><img decoding=\"async\" class=\"size-full wp-image-22790\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befb1860f51f6d3474fba550ae3d20e3-1.jpg\" alt=\"\" width=\"448\" height=\"416\" title=\"\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befb1860f51f6d3474fba550ae3d20e3-1.jpg 448w, \/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befb1860f51f6d3474fba550ae3d20e3-1-300x279.jpg 300w, \/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befb1860f51f6d3474fba550ae3d20e3-1-150x139.jpg 150w\" sizes=\"(max-width: 448px) 100vw, 448px\" \/><\/a><figcaption id=\"caption-attachment-22790\" class=\"wp-caption-text\">\u98a8\u96aa\u8f03\u9ad8\u2014\u2014\u9ad8\u9f61\u764c\u75c7\u75c5\u4eba\u82e5\u540c\u6642\u6709\u6162\u6027\u75c5\uff0c\u624b\u8853\u548c\u5316\u7642\u98a8\u96aa\u8f03\u9ad8\u3002\uff08\u5716\uff1amonkeybusinessimages@iStockphoto\uff0c\u8a2d\u8a08\u5716\u7247\uff0c\u76f8\u4e2d\u6a21\u7279\u5152\u975e\u6587\u4e2d\u500b\u6848\u4e8b\u4e3b\uff09<\/figcaption><\/figure>\n<p>\u5718\u968a\u56e0\u6b64\u518d\u6b21\u5efa\u8b70\u674e\u5148\u751f\uff0c\u63a5\u53d7\u524d\u5217\u817a\u764c\u7684\u7a7f\u523a\u6d3b\u6aa2\uff0c\u5617\u8a66\u5f9e\u75c5\u7406\u548c\u5206\u5b50\u8a3a\u65b7\u6280\u8853\u5206\u6790\u816b\u7624\uff0c\u4ee5\u5c0b\u6c42\u6700\u597d\u7684\u6cbb\u7642\u65b9\u6cd5\u3002<\/p>\n<p>\u75c5\u7406\u5206\u6790\u662f\u897f\u65b9\u91ab\u5b78\u7684\u57fa\u77f3\u3002\u50b3\u7d71\u7684\u816b\u7624\u75c5\u7406\u5316\u9a57\u4e3b\u8981\u662f\u4f9d\u9760\u91ab\u751f\u6191\u8089\u773c\u548c\u7d93\u9a57\uff0c\u5728\u986f\u5fae\u93e1\u4e0b\u5206\u6790\u7d30\u80de\u548c\u7d44\u7e54\u7684\u7d50\u69cb\u3001\u5f62\u72c0\u3001\u5206\u4f48\uff0c\u518d\u52a0\u4e0a\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u6cd5\uff08IHC\uff09\u5c0d\u816b\u7624\u4f5c\u51fa\u8a3a\u65b7\u548c\u5206\u985e\u3002<\/p>\n<p>\u96a8\u5206\u5b50\u751f\u7269\u5b78\u7684\u9032\u6b65\uff0c\u8fd1\u5e74\u57fa\u56e0\u5206\u6790\u7684\u6210\u672c\u5927\u5927\u964d\u4f4e\uff0c\u540c\u6b65\u5206\u6790\u6578\u767e\u4ee5\u81f3\u4e0a\u5343\u500b\u816b\u7624\u57fa\u56e0\u5df2\u7d93\u53ef\u4ee5\u5728\u81e8\u7240\u60c5\u51b5\u4e0b\u57f7\u884c\u3002\u9019\u6280\u8853\u7a81\u7834\u540d\u70ba\u300c\u6b21\u4e16\u4ee3\u5b9a\u5e8f\u300d\uff08Next generation sequencing\uff0cNGS\uff09\u3002\u9019\u4e9b\u57fa\u56e0\u8b8a\u7570\u8cc7\u6599\u70ba\u75c5\u7406\u5206\u6790\u63d0\u4f9b\u4e86\u5927\u91cf\u7684\u6578\u64da\u57fa\u790e\uff0c\u4ee4\u91ab\u7642\u5718\u968a\u53ef\u4ee5\u5c0d\u6bcf\u500b\u75c5\u4eba\u5728\u4e0d\u540c\u75c5\u60c5\u968e\u6bb5\u7684\u816b\u7624\u4f5c\u500b\u4eba\u5316\u5206\u6790\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u65b0\u6291\u5236\u5291\u91dd\u5c0d\u7f55\u898b\u57fa\u56e0<\/h2>\n<p>\u674e\u5148\u751f\u6700\u7d42\u63a5\u53d7\u4e86\u524d\u5217\u817a\u7d44\u7e54\u6aa2\u67e5\u3002\u75c5\u7406\u79d1\u91ab\u751f\u78ba\u5b9a\u4e86\u674e\u5148\u751f\u60a3\u6709\u9ad8\u5ea6\u6d3b\u8e8d\u300c\u795e\u7d93\u5167\u5206\u6ccc\u524d\u5217\u817a\u764c\u300d\uff0c\u816b\u7624\u5e36\u6709\u7f55\u898b\u7684\u96d9\u91cd\u300cBRCAness\u300d\u57fa\u56e0\u7a81\u8b8a\u3002BRCAness\u57fa\u56e0\u7d44\u9996\u5148\u5728\u4e73\u764c\u548c\u5375\u5de2\u764c\u4e2d\u88ab\u767c\u73fe\uff0c\u9019\u985e\u57fa\u56e0\u7a81\u8b8a\u5c0e\u81f4\u816b\u7624\u57fa\u56e0\u6709\u4fee\u5fa9\u7f3a\u9677\u3002\u65b0\u5f0f\u85e5\u7269\u300cPARP\u300d\u6291\u5236\u5291\u91dd\u5c0d\u816b\u7624\u7d30\u80de\u9019\u4e00\u5f31\u9ede\uff0c\u4ee4\u672c\u8eab\u57fa\u56e0\u5df2\u4e0d\u7a69\u5b9a\u7684\u816b\u7624\u7d30\u80de\uff0c\u57fa\u56e0\u8b8a\u5f97\u66f4\u4e0d\u7a69\u5b9a\uff0c\u7e7c\u800c\u5f15\u81f4\u816b\u7624\u7d30\u80de\u6b7b\u4ea1\u3002<\/p>\n<figure id=\"attachment_22792\" aria-describedby=\"caption-attachment-22792\" style=\"width: 550px\" class=\"wp-caption alignnone\"><a href=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befafa36cf7954e403ae50e34a934897-1.jpg\"><img decoding=\"async\" class=\"size-full wp-image-22792\" src=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befafa36cf7954e403ae50e34a934897-1.jpg\" alt=\"\u767c\u73fe\u7a81\u8b8a\" width=\"550\" height=\"920\" title=\"\" srcset=\"\/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befafa36cf7954e403ae50e34a934897-1.jpg 550w, \/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befafa36cf7954e403ae50e34a934897-1-179x300.jpg 179w, \/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befafa36cf7954e403ae50e34a934897-1-90x150.jpg 90w, \/\/www.afterroberto.com\/wp-content\/uploads\/2017\/11\/befafa36cf7954e403ae50e34a934897-1-149x250.jpg 149w\" sizes=\"(max-width: 550px) 100vw, 550px\" \/><\/a><figcaption id=\"caption-attachment-22792\" class=\"wp-caption-text\">\u767c\u73fe\u7a81\u8b8a\u2014\u2014\u6709\u75c5\u4eba\u7684\u524d\u5217\u817a\u764c\u8f49\u79fb\u81f3\u8166\u90e8\uff0c\u900f\u904e\u300c\u6b21\u4e16\u4ee3\u5b9a\u5e8f\u300d\u9a57\u6e2c\uff0c\u767c\u73fe\u816b\u7624\u5e36\u6709\u67d0\u7a2e\u57fa\u56e0\u7a81\u8b8a\uff0c\u60a3\u8005\u56e0\u800c\u53ef\u501f\u7528\u91dd\u5c0d\u7684\u85e5\u7269\u4f86\u6cbb\u7642\u3002\uff08\u5716\uff1adecade3d\u3001yodiyim@iStockphoto\uff09<\/figcaption><\/figure>\n<p>\u5728\u5927\u578b\u81e8\u7240\u8a66\u9a57\u4e2d\uff0c\u300cPARP\u300d\u6291\u5236\u5291\u6210\u529f\u63d0\u9ad8\u4e86\u5375\u5de2\u764c\u75c5\u4eba\u7684\u5b58\u6d3b\u7387\u3002\u5728\u5375\u5de2\u764c\u4ee5\u5916\uff0c\u5176\u4ed6\u5e36\u6709BRCAness\u57fa\u56e0\u7684\u816b\u7624\u4e5f\u5f88\u6709\u53ef\u80fd\u6709\u76f8\u4f3c\u7279\u5fb5\u30022015\u5e7411\u6708\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u671f\u520a\u767c\u8868\u4e86\u9996\u500b\u5831\u544a\uff0c\u767c\u73fe\u572816\u500b\u5e36\u6709BRCAness\u57fa\u56e0\u7684\u524d\u5217\u817a\u764c\u4e2d\uff0c14\u500b\uff0888%\uff09\u5c0dPARP\u6291\u5236\u5291\u6709\u826f\u597d\u6548\u679c\u3002\u4e00\u90e8\u5206\u80f0\u817a\u764c\u548c\u300c\u4e09\u9670\u6027\u300d\u4e73\u764c\u5c0dPARP\u6291\u5236\u5291\u4e5f\u6709\u53cd\u61c9\u3002<\/p>\n<p>\u7d93\u8a73\u7d30\u8a0e\u8ad6\uff0c\u674e\u5148\u751f\u6c7a\u5b9a\u8a66\u7528PARP\u6291\u5236\u5291\u3002\u670d\u7528\u5169\u5468\u5f8c\uff0c\u524d\u5217\u817a\u5c3f\u9053\u75c5\u5fb5\u6709\u660e\u986f\u6539\u5584\u3002\u56db\u5468\u5f8c\uff0c\u78c1\u529b\u5171\u632f\u986f\u793a\u8166\u90e8\u816b\u7624\u7e2e\u5c0f\u3002\u516b\u5468\u5f8c\uff0c\u5927\u90e8\u5206\u8166\u90e8\u816b\u7624\u6d88\u5931\uff08\u5716\u4e09\uff09\u3002\u5341\u6708\uff0c\u674e\u5148\u751f\u548c\u773e\u5b6b\u5152\u5ea6\u904e\u4e86\u4e00\u500b\u6109\u5feb\u768482\u6b72\u751f\u65e5\u3002<\/p>\n<p>\u6587\uff1a\u6797\u6cf0\u5fe0\uff08\u9999\u6e2f\u5927\u5b78\u81e8\u7240\u816b\u7624\u79d1\u81e8\u7240\u52a9\u7406\u6559\u6388\uff09<\/p>\n<p>\u5716\uff1a\u53d7\u8a2a\u8005\u63d0\u4f9b<\/p>\n<p>\u7de8\u8f2f\uff1a\u738b\u7fe0\u9e97<\/p>\n<p>\u96fb\u90f5\uff1a<a href=\"mailto:feature@mingpao.com\" target=\"_blank\" rel=\"noopener noreferrer\">feature@mingpao.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u660e\u5831\u5c08\u8a0a\u3011\u65b0\u7642\u6cd5\uff1a\u6b21\u4e16\u4ee3\u5b9a\u5e8f Next generation sequencing\uff0cNGS 81\u6b72\u674e\u5148\u751f\u7684\u524d\u5217\u817a\u764c\u8f49\u79fb\uff0c\u4eca\u5e74\u4e8c\u6708\u56e0\u982d\u75db\u982d\u6688\u5165\u9662\uff0c\u767c\u73fe\u8166\u90e8\u6709\u5341\u591a\u500b\u816b\u7624\u3002\u63a5\u53d7\u96fb\u7642\u3001\u8377\u723e\u8499\u6cbb\u7642\u5f8c\u5fb5\u72c0\u660e\u986f\u6e1b\u5c11\uff0c\u4f46\u4e09\u500b\u6708\u5f8c\uff0c\u8166\u90e8\u65b0\u51fa\u73fe\u8fd120\u500b\u816b\u7624\u3002 \u816b\u7624\u5982\u6b64\u5147\u60e1\uff0c\u5341\u5206\u7f55\u898b\u3002\u9762\u5c0d\u9ad8\u9f61\u53ca\u6709\u5176\u4ed6\u6162\u6027\u75c5\u7684\u674e\u5148\u751f\uff0c\u91ab\u7642\u5718\u968a\u53ea\u80fd\u5750\u4ee5\u5f85\u6583\uff1f\u57fa\u56e0\u6aa2\u6e2c\u3001\u6a19\u9776\u85e5\u7269\u5982\u4f55\u5e6b\u52a9\u674e\u5148\u751f\u5b89\u5ea682\u6b72\u751f\u65e5\uff1f &nbsp; \u500b\u6848 \u8001\u7fc1\u524d\u5217\u817a\u764c\u4e0a\u8166 \u6cbb\u7642\u56f0\u96e3 \u674e\u5148\u751f\u53bb\u5e74\u56e0\u80ba\u708e\u4f4f\u9662\uff0c\u5176\u9593\u767c\u73fe\u524d\u5217\u817a\u764c\u6307\u6578\uff08PSA\uff09\u7a0d\u9ad8\u3002\u6642\u5e7481\u6b72\u7684\u4ed6\u6709\u6162\u6027\u80ba\u6c23\u816b\uff0c\u4e0d\u5e0c\u671b\u505a\u524d\u5217\u817a\u7a7f\u523a\u6aa2\u67e5\uff0c\u4fbf\u6c7a\u5b9a\u4ee5\u4fdd\u5b88\u6cbb\u7642\uff0c\u89c0\u5bdfPSA\u7684\u8d70\u52e2\u3002 \u6578\u6708\u904e\u53bb\uff0c\u674e\u5148\u751f\u8eab\u9ad4\u60c5\u51b5\u5c1a\u7b97\u7a69\u5b9a\uff0cPSA\u6307\u6578\u53ea\u662f\u4e0a\u5347\u4e86\u5c11\u8a31\u3002\u4f46\u4eca\u5e742\u6708\u674e\u5148\u751f\u7a81\u7136\u89ba\u5f97\u982d\u6688\u982d\u75db\uff0c\u6b65\u5c65\u4e0d\u7a69\u3002\u5165\u9662\u6aa2\u67e5\u7adf\u767c\u73fe\u8166\u90e8\u6709\u5341\u591a\u500b\u816b\u7624\uff0c\u6700\u5927\u7684\u4e00\u500b\u76f4\u5f91\u90543.5\u5398\u7c73\uff0c\u58d3\u8feb\u8166\u5e79\u795e\u7d93\uff08\u5716\u4e00\uff09\u3002\u5168\u8eab\u6b63\u96fb\u5b50\u6383\u63cf\u767c\u73fe\u524d\u5217\u817a\u548c\u76c6\u8154\u6dcb\u5df4\u70ba\u53ef\u7591\u7684\u816b\u7624\u6e90\u982d\u3002 \u674e\u5148\u751f\u75c5\u60c5\u5341\u5206\u5371\u6025\u3002\u8166\u5916\u79d1\u548c\u9ebb\u9189\u79d1\u8a8d\u70ba\u75c5\u4eba\u80ba\u529f\u80fd\u4e0d\u597d\uff0c\u4e14\u8166\u90e8\u8840\u7ba1\u6709\u56b4\u91cd\u786c\u5316\uff0c\u505a\u958b\u8166\u624b\u8853\u98a8\u96aa\u904e\u9ad8\u3002\u75c5\u4eba\u4e5f\u4e0d\u5e0c\u671b\u5192\u592a\u5927\u98a8\u96aa\u3002\u5718\u968a\u70ba\u5148\u751f\u5b89\u6392\u4e86\u7acb\u9ad4\u5b9a\u5411\u653e\u5c04\u624b\u8853\uff08stereotactic radiosurgery\uff0cSRS\uff09\uff0c\u4ee5\u9ad8\u6e96\u78ba\u5ea6\u53ca\u9ad8\u5291\u91cf\u7684X\u5149\uff0c\u91dd\u5c0d\u8166\u90e814\u500b\u816b\u7624\u9032\u884c\u653e\u5c04\u6cbb\u7642\u3002 SRS\u5f8c\uff0c\u674e\u5148\u751f\u7684\u8166\u90e8\u75c5\u5fb5\u660e\u986f\u6e1b\u8f15\uff0c\u5718\u968a\u4ea6\u70ba\u674e\u5148\u751f\u5b89\u6392\u8377\u723e\u8499\u6cbb\u7642\uff0c\u524d\u5217\u817a\u764c\u6307\u6578\u9010\u6f38\u4e0b\u964d\u3002SRS\u5f8c\u4e00\u500b\u6708\u7684\u78c1\u529b\u5171\u632f\u767c\u73fe\u8166\u90e8\u816b\u7624\u5168\u90e8\u90fd\u660e\u986f\u7e2e\u5c0f\u4e86\u3002 \u53ef\u662f\uff0cSRS\u5f8c\u4e09\u500b\u6708\uff0c\u78c1\u529b\u5171\u632f\u518d\u6b21\u767c\u73fe\u8166\u90e8\u51fa\u73fe\u4e86\u8fd120\u500b\u65b0\u7684\u816b\u7624\uff08\u5716\u4e8c\uff09\u3002\u5168\u8eab\u6b63\u96fb\u5b50\u6383\u63cf\u4e5f\u767c\u73fe\u76c6\u8154\u548c\u8179\u90e8\u7684\u816b\u7624\u6578\u76ee\u589e\u52a0\u4e86\u3002 &nbsp; \u9ad8\u9f61\u517c\u6162\u6027\u75c5\u60a3 \u5316\u7642\u98a8\u96aa\u5927 \u8377\u723e\u8499\u6cbb\u7642\u5c0d\u524d\u5217\u817a\u764c\u7684\u63a7\u5236\uff0c\u901a\u5e38\u90fd\u8d85\u904e6\u81f312\u500b\u6708\uff0c\u674e\u5148\u751f\u75c5\u60c5\u57283\u500b\u6708\u5167\u6025\u901f\u60e1\u5316\u7740\u5be6\u7f55\u898b\u3002\u82e5\u8ddf\u96a8\u50b3\u7d71\u7684\u524d\u5217\u817a\u764c\u6cbb\u7642\u6307\u5f15\uff0c\u674e\u5148\u751f\u53ef\u80fd\u8981\u8003\u616e\u5316\u5b78\u6cbb\u7642\uff0c\u4f46\u4ee5\u903e80\u6b72\u9ad8\u9f61\u4e14\u8eab\u9ad4\u6709\u6162\u6027\u75be\u75c5\u7684\u8003\u616e\u4e0b\uff0c\u5316\u7642\u98a8\u96aa\u5be6\u5728\u592a\u9ad8\uff0c\u7642\u6548\u4e0d\u592a\u660e\u986f\uff0c\u800c\u4e14\u85e5\u7269\u672a\u5fc5\u80fd\u9032\u5165\u8166\u90e8\u63a7\u5236\u816b\u7624\u64f4\u6563\u3002 \u5718\u968a\u56e0\u6b64\u518d\u6b21\u5efa\u8b70\u674e\u5148\u751f\uff0c\u63a5\u53d7\u524d\u5217\u817a\u764c\u7684\u7a7f\u523a\u6d3b\u6aa2\uff0c\u5617\u8a66\u5f9e\u75c5\u7406\u548c\u5206\u5b50\u8a3a\u65b7\u6280\u8853\u5206\u6790\u816b\u7624\uff0c\u4ee5\u5c0b\u6c42\u6700\u597d\u7684\u6cbb\u7642\u65b9\u6cd5\u3002 \u75c5\u7406\u5206\u6790\u662f\u897f\u65b9\u91ab\u5b78\u7684\u57fa\u77f3\u3002\u50b3\u7d71\u7684\u816b\u7624\u75c5\u7406\u5316\u9a57\u4e3b\u8981\u662f\u4f9d\u9760\u91ab\u751f\u6191\u8089\u773c\u548c\u7d93\u9a57\uff0c\u5728\u986f\u5fae\u93e1\u4e0b\u5206\u6790\u7d30\u80de\u548c\u7d44\u7e54\u7684\u7d50\u69cb\u3001\u5f62\u72c0\u3001\u5206\u4f48\uff0c\u518d\u52a0\u4e0a\u514d\u75ab\u7d44\u7e54\u5316\u5b78\u67d3\u8272\u6cd5\uff08IHC\uff09\u5c0d\u816b\u7624\u4f5c\u51fa\u8a3a\u65b7\u548c\u5206\u985e\u3002 \u96a8\u5206\u5b50\u751f\u7269\u5b78\u7684\u9032\u6b65\uff0c\u8fd1\u5e74\u57fa\u56e0\u5206\u6790\u7684\u6210\u672c\u5927\u5927\u964d\u4f4e\uff0c\u540c\u6b65\u5206\u6790\u6578\u767e\u4ee5\u81f3\u4e0a\u5343\u500b\u816b\u7624\u57fa\u56e0\u5df2\u7d93\u53ef\u4ee5\u5728\u81e8\u7240\u60c5\u51b5\u4e0b\u57f7\u884c\u3002\u9019\u6280\u8853\u7a81\u7834\u540d\u70ba\u300c\u6b21\u4e16\u4ee3\u5b9a\u5e8f\u300d\uff08Next generation sequencing\uff0cNGS\uff09\u3002\u9019\u4e9b\u57fa\u56e0\u8b8a\u7570\u8cc7\u6599\u70ba\u75c5\u7406\u5206\u6790\u63d0\u4f9b\u4e86\u5927\u91cf\u7684\u6578\u64da\u57fa\u790e\uff0c\u4ee4\u91ab\u7642\u5718\u968a\u53ef\u4ee5\u5c0d\u6bcf\u500b\u75c5\u4eba\u5728\u4e0d\u540c\u75c5\u60c5\u968e\u6bb5\u7684\u816b\u7624\u4f5c\u500b\u4eba\u5316\u5206\u6790\u3002 &nbsp; \u65b0\u6291\u5236\u5291\u91dd\u5c0d\u7f55\u898b\u57fa\u56e0 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